Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Bevin P, Engelward"'
Publikováno v:
ACS Omega, Vol 9, Iss 35, Pp 37076-37085 (2024)
Externí odkaz:
https://doaj.org/article/ef873373f8e5475baa5dafd0ae96a81d
Publikováno v:
ACS Omega, Vol 9, Iss 41, Pp 42612-42612 (2024)
Externí odkaz:
https://doaj.org/article/0e5bcefa8e1541fe8906d0cf7b864a77
Autor:
Julie K. Buick, Andrea Rowan-Carroll, Rémi Gagné, Andrew Williams, Renxiang Chen, Heng-Hong Li, Albert J. Fornace, Christy Chao, Bevin P. Engelward, Roland Frötschl, Heidrun Ellinger-Ziegelbauer, Syril D. Pettit, Jiri Aubrecht, Carole L. Yauk
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Genotoxicity testing relies on the detection of gene mutations and chromosome damage and has been used in the genetic safety assessment of drugs and chemicals for decades. However, the results of standard genotoxicity tests are often difficult to int
Externí odkaz:
https://doaj.org/article/e639082783d548ec8aa9253661029295
Autor:
Aoli Xiong, Simran Kaushal, Ian Junjie Tay, Bevin P. Engelward, Jongyoon Han, Peter R. Preiser
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100797- (2021)
Summary: Comet assay is a standard approach for studying DNA damage in malaria, but high-throughput options are not available. The CometChip was previously developed using mammalian cells as a high-throughput version of the comet assay. It is based o
Externí odkaz:
https://doaj.org/article/0a6b0d38982740a2bba334d1bd35f6eb
Autor:
Jamie M. Kelly, Peter D. Ivatt, Mathew J. Evans, Jesse H. Kroll, Amy I. H. Hrdina, Ishwar N. Kohale, Forest M. White, Bevin P. Engelward, Noelle E. Selin
Publikováno v:
GeoHealth, Vol 5, Iss 9, Pp n/a-n/a (2021)
Abstract In assessments of cancer risk from atmospheric polycyclic aromatic hydrocarbons (PAHs), scientists and regulators rarely consider the complex mixture of emitted compounds and degradation products, and they often represent the entire mixture
Externí odkaz:
https://doaj.org/article/9188358648a44ebe856f0fd2242ba486
Autor:
Julie K. Buick, Andrew Williams, Matthew J. Meier, Carol D. Swartz, Leslie Recio, Rémi Gagné, Stephen S. Ferguson, Bevin P. Engelward, Carole L. Yauk
Publikováno v:
Frontiers in Public Health, Vol 9 (2021)
Higher-throughput, mode-of-action-based assays provide a valuable approach to expedite chemical evaluation for human health risk assessment. In this study, we combined the high-throughput alkaline DNA damage-sensing CometChip® assay with the TGx-DDI
Externí odkaz:
https://doaj.org/article/e4d39a8558a149fc9ffab87e469ad97d
Autor:
Aoli Xiong, Prem Prakash, Xiaohong Gao, Marvin Chew, Ian Jun Jie Tay, Charles J. Woodrow, Bevin P. Engelward, Jongyoon Han, Peter R. Preiser
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107996- (2020)
Summary: Southeast Asia has been the hotbed for the development of drug-resistant malaria parasites, including those with resistance to artemisinin combination therapy. While mutations in the kelch propeller domain (K13 mutations) are associated with
Externí odkaz:
https://doaj.org/article/23a3e6e5cd1d4f26a0513b7038e8eb83
Publikováno v:
Cell Reports, Vol 26, Iss 6, Pp 1668-1678.e4 (2019)
Summary: Cell survival is a critical and ubiquitous endpoint in biology. The broadly accepted colony formation assay (CFA) directly measures a cell’s ability to divide; however, it takes weeks to perform and is incompatible with high-throughput scr
Externí odkaz:
https://doaj.org/article/307bec8b38724df1bd71225c2dcd8bfe
Autor:
Amanda L Armijo, Pennapa Thongararm, Bogdan I Fedeles, Judy Yau, Jennifer E Kay, Joshua J Corrigan, Marisa Chancharoen, Supawadee Chawanthayatham, Leona D Samson, Sebastian E Carrasco, Bevin P Engelward, James G Fox, Robert G Croy, John M Essigmann
Publikováno v:
NAR Cancer. 5
DNA-methylating environmental carcinogens such as N-nitrosodimethylamine (NDMA) and certain alkylators used in chemotherapy form O6-methylguanine (m6G) as a functionally critical intermediate. NDMA is a multi-organ carcinogen found in contaminated wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4070f6d0bc303354aa24c64ca34ce318
https://doi.org/10.1093/narcan/zcad015
https://doi.org/10.1093/narcan/zcad015
Autor:
Bevin P. Engelward, Isaac A. Chaim, Patrizia Mazzucato, Catherine Ricciardi, Zachary D. Nagel, Leona D. Samson, Simran Kaushal, Le P. Ngo
Publikováno v:
Free Radic Biol Med
Although DNA repair is known to impact susceptibility to cancer and other diseases, relatively few population studies have been performed to evaluate DNA repair kinetics in people due to the difficulty of assessing DNA repair in a high throughput man
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5665e6ed1db86689e41cd947316ef6a
https://doi.org/10.1016/j.freeradbiomed.2021.07.033
https://doi.org/10.1016/j.freeradbiomed.2021.07.033