Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Beverly S. Chilton"'
Autor:
Rachel L. Washburn, Dalia Martinez-Marin, Tyler Sniegowski, Ksenija Korać, Alexis R. Rodriguez, Jonathan M. Miranda, Beverly S. Chilton, Robert K. Bright, Kevin Pruitt, Yangzom D. Bhutia, Jannette M. Dufour
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1650 (2023)
Transplantation is a clinical procedure that treats a variety of diseases yet is unattainable for many patients due to a nationwide organ shortage and the harsh side effects of chronic immune suppression. Xenografted pig organs are an attractive alte
Externí odkaz:
https://doaj.org/article/b54c88465c0646c0ae6edfd99d7c02ae
Autor:
Rebecca A Helmer, Raul Martinez-Zaguilan, Gurvinder Kaur, Lisa A Smith, Jannette M Dufour, Beverly S Chilton
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251132 (2021)
Methylation of the HLTF gene in colorectal cancer (CRC) cells occurs more frequently in men than women. Progressive epigenetic silencing of HLTF in tumor cells is accompanied by negligible expression in the tumor microenvironment (TME). Cell line-der
Externí odkaz:
https://doaj.org/article/8ecbe03233c9424b873ff31a5f9221a6
Autor:
Dufour, Rachel L. Washburn, Dalia Martinez-Marin, Tyler Sniegowski, Ksenija Korać, Alexis R. Rodriguez, Jonathan M. Miranda, Beverly S. Chilton, Robert K. Bright, Kevin Pruitt, Yangzom D. Bhutia, Jannette M.
Publikováno v:
Biomedicines; Volume 11; Issue 6; Pages: 1650
Transplantation is a clinical procedure that treats a variety of diseases yet is unattainable for many patients due to a nationwide organ shortage and the harsh side effects of chronic immune suppression. Xenografted pig organs are an attractive alte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::23533812746dbf1ca20d68f331b3a6e7
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221751 (2019)
The helicase-like transcription factor (HLTF) gene-a tumor suppressor in human colorectal cancer (CRC)-is regulated by alternative splicing and promoter hypermethylation. In this study, we used the AOM/DSS-induced mouse model to show Hltf-deletion ca
Externí odkaz:
https://doaj.org/article/b874977bcc104b0db498510592f0d636
Autor:
Gurvinder Kaur, Rebecca A Helmer, Lisa A Smith, Raul Martinez-Zaguilan, Jannette M Dufour, Beverly S Chilton
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200211 (2018)
Hltf is regulated by intron retention, and global Hltf-deletion causes perinatal lethality from hypoglycemia. In heart, full-length Hltf is a transcriptional regulator of Hif-1α that controls transport systems. Thus, we tested the hypothesis that Hl
Externí odkaz:
https://doaj.org/article/485b39849fc04804b69131ee5a7e66c7
Autor:
Rachel L. Washburn, Dalia Martinez-Marin, Ksenija Korać, Tyler Sniegowski, Alexis R. Rodriguez, Beverly S. Chilton, Taylor Hibler, Kevin Pruitt, Yangzom D. Bhutia, Jannette M. Dufour
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 3; Pages: 1890
The complement system is an important component of transplant rejection. Sertoli cells, an immune regulatory testicular cell, survive long-term when transplanted across immunological barriers; thus, understanding the mechanisms behind this unique sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7c0af48b502dd7c65e6e79dc0f3519
https://doi.org/10.3390/ijms24031890
https://doi.org/10.3390/ijms24031890
Autor:
Rebecca A Helmer, not provided Raul Martinez-Zaguilan, not provided Gurvinder Kaur, not provided Lisa A Smith, not provided Jannette M Dufour, Beverly S Chilton
Methylation of the HLTF gene in colorectal cancer (CRC) cells occurs more frequently in men than women. Progressive epigenetic silencing of HLTF in tumor cells is accompanied by negligible expression in the tumor microenvironment (TME). Cell line-der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e7b5da92e0a0bf4a38bff3c7ac4b6dc
https://doi.org/10.17504/protocols.io.bs5xng7n
https://doi.org/10.17504/protocols.io.bs5xng7n
Autor:
Rebecca A Helmer, Raul Martínez-Zaguilán, Janet S Dertien, Candra Fulford, Oded Foreman, Vasum Peiris, Beverly S Chilton
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80461 (2013)
HLTF/Hltf regulates transcription, remodels chromatin, and coordinates DNA damage repair. Hltf is expressed in mouse brain and heart during embryonic and postnatal development. Silencing Hltf is semilethal. Seventy-four percent of congenic C57BL/6J H
Externí odkaz:
https://doaj.org/article/0c1e717c2a1a428192cd73e6e20cc255
Autor:
Rebecca A Helmer, Oded Foreman, Janet S Dertien, Marlyn Panchoo, Suhani M Bhakta, Beverly S Chilton
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e66799 (2013)
HLTF participates in transcription, chromatin remodeling, DNA damage repair, and tumor suppression. Aside from being expressed in mouse brain during embryonic and postnatal development, little is known about Hltf's functional importance. Splice varia
Externí odkaz:
https://doaj.org/article/9994306386434abcade805143dfd9f04
Epigenetic silencing of HLTF in human β cells alters insulin secretion and is associated with diabetes. Here we examine the effects of Hltf-deletion on β cell function in genetically engineered mouse models. The developmental timeline for the exclu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ce0ad497c80c8530d3cd4aba0b056fe
https://doi.org/10.17504/protocols.io.7xvhpn6
https://doi.org/10.17504/protocols.io.7xvhpn6