Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Beverly S, Mitchell"'
In vivo analysis of patients AML1-3 including (A) H2O2 levels, (B) WBC counts of AML3 during ixazomib treatment (arrow marks when hydrea stopped), and (C) mRNA expression (AML2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1073fd6ca579b58db42f8d5dff352bc4
https://doi.org/10.1158/1078-0432.22460634.v1
https://doi.org/10.1158/1078-0432.22460634.v1
(A) Representative FACS plot of sorted NPMc+ primary leukemic blasts (patient AML6) and (B) mRNA expression by qPCR using the same AML patient samples tested in Figure 4.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::006dfea7fd5427996001e6207e2ffe58
https://doi.org/10.1158/1078-0432.22460637
https://doi.org/10.1158/1078-0432.22460637
Patient characteristics and molecular phenotypes of primary AML samples used.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1071cdcf9675155bb8deef1fe486000f
https://doi.org/10.1158/1078-0432.22460625
https://doi.org/10.1158/1078-0432.22460625
Supplemental Figure S3. Relative expression of Ebp1 and rRNA synthesis in bone marrow cells from control and MLL-AF9 and MLL-AF10 mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732a583de3092ee0a42ba9bc61632737
https://doi.org/10.1158/1078-0432.22457018.v1
https://doi.org/10.1158/1078-0432.22457018.v1
Primer sequences for GCLC, GCLM, NQO1, NRF2 and GAPDH analysis by real-time RT-PCR analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a94cb4f967cf4422219f0f971d3466d
https://doi.org/10.1158/1078-0432.22460628
https://doi.org/10.1158/1078-0432.22460628
Effects of combining ixazomib and Trichostatin A (TSA) (A, B, C), and of combining bortezomib and SAHA (D, E) in OCI-AML3 cells with or without depletion of NPMc+ expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c19b96ec6be05b5926f99a66afa9a95
https://doi.org/10.1158/1078-0432.22460631.v1
https://doi.org/10.1158/1078-0432.22460631.v1
Purpose: The ErbB3-binding protein 1 (Ebp1) has been implicated in diverse cancers as having either oncogenic or tumor suppressor activities. The present study was undertaken to determine the effects of Ebp1 expression in AML cells and to determine t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0681e83e1c61f95e5c56b228f130e194
https://doi.org/10.1158/1078-0432.c.6523481.v1
https://doi.org/10.1158/1078-0432.c.6523481.v1
(A) Cytotoxicity of ixazomib compared to MLN2238 (IC50 = 63.68 {plus minus} 5.3 nM) in OCI-AML3 cells. Plots of (B) GFP expression by K562 cells ectopically expressing constructs (C) treated with ixazomib.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fd1d15666ca351ebfaeb44e6827d19
https://doi.org/10.1158/1078-0432.22460646
https://doi.org/10.1158/1078-0432.22460646
Evaluation of induction of (A) reactive oxygen species, (B) hydrogen peroxide (H2O2), and of the N-acetylcysteine (NAC) pre-treatment effect on ixazomib-induced (C) superoxide and (D) apoptosis in OCI-AML3 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f203e68afc2dac2815381298fc17271
https://doi.org/10.1158/1078-0432.22460643.v1
https://doi.org/10.1158/1078-0432.22460643.v1
(A) GSH to GSSG ratio, (B) reduced GSH, and (C) oxidized glutathione (GSSG) in OCI-AML3 cells (ixazomib 150nM, 22h treatment).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b723ac91e464060a74971f5b79aff235
https://doi.org/10.1158/1078-0432.22460640
https://doi.org/10.1158/1078-0432.22460640