Výsledky vyhledávání - "Beverly Orillo"

Akademický článek

West Nile virus-induced cell adhesion molecules on human brain microvascular endothelial cells regulate leukocyte adhesion and modulate permeability of the in vitro blood-brain barrier model.

Autor: Kelsey Roe, Beverly Orillo, Saguna Verma

Publikováno v: PLoS ONE, Vol 9, Iss 7, p e102598 (2014)

Characterizing the mechanisms by which West Nile virus (WNV) causes blood-brain barrier (BBB) disruption, leukocyte infiltration into the brain and neuroinflammation is important to understand the pathogenesis of WNV encephalitis. Here, we examined t

Externí odkaz: https://doaj.org/article/129006d5fe7c4d2a8e764ee8e9b306ad

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Akademický článek

Impaired virus clearance, compromised immune response and increased mortality in type 2 diabetic mice infected with West Nile virus.

Autor: Mukesh Kumar, Kelsey Roe, Pratibha V Nerurkar, Madhuri Namekar, Beverly Orillo, Saguna Verma, Vivek R Nerurkar

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e44682 (2012)

Clinicoepidemiological data suggest that type 2 diabetes is associated with increased risk of West Nile virus encephalitis (WNVE). However, no experimental studies have elucidated the role of diabetes in WNV neuropathogenesis. Herein, we employed the

Externí odkaz: https://doaj.org/article/6d38acff9bfe43ba93beb3ab503a5bb3

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Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection

Autor: Saguna Verma, Pei Yong Shi, Beverly Orillo, Jacob Nelson, Kelsey Roe

West Nile virus (WNV), a member of the Flaviviridae family, is the leading cause of viral encephalitis in the United States. Despite efforts to control the spread of WNV, there has been an increase in the number of outbreaks and clinical cases with n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bc2c36c2dd51aa7ed6f52f0b377c4f
https://europepmc.org/articles/PMC4853296/

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Reduced immune cell infiltration and increased pro-inflammatory mediators in the brain of Type 2 diabetic mouse model infected with West Nile virus

Autor: Pratibha V. Nerurkar, Beverly Orillo, Karen S. Thompson, Mukesh Kumar, Vivek R. Nerurkar, Saguna Verma, Kelsey Roe

Publikováno v: Journal of Neuroinflammation

Background Diabetes is a significant risk factor for developing West Nile virus (WNV)-associated encephalitis (WNVE) in humans, the leading cause of arboviral encephalitis in the United States. Using a diabetic mouse model (db/db), we recently demons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f7b7fbc066a0eb2d79f77e3522dfed
https://pubmed.ncbi.nlm.nih.gov/24750819

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West Nile virus-induced disruption of the blood–brain barrier in mice is characterized by the degradation of the junctional complex proteins and increase in multiple matrix metalloproteinases

Autor: Mukesh Kumar, Kelsey Roe, Saguna Verma, Vivek R. Nerurkar, Stephanie Lum, Beverly Orillo

West Nile virus (WNV) encephalitis is characterized by neuroinflammation, neuronal loss and blood–brain barrier (BBB) disruption. However, the mechanisms associated with the BBB disruption are unclear. Complex interactions between the tight junctio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f680f073655e7d1825ba179d85ef12e
https://europepmc.org/articles/PMC3755517/

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Impaired virus clearance, compromised immune response and increased mortality in type 2 diabetic mice infected with West Nile virus

Autor: Beverly Orillo, Vivek R. Nerurkar, Pratibha V. Nerurkar, Madhuri Namekar, Kelsey Roe, Mukesh Kumar, Saguna Verma

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 8, p e44682 (2012)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c056ccdc5c784958ad569c0d6461fc
https://pubmed.ncbi.nlm.nih.gov/22953001

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West Nile Virus-Induced Cell Adhesion Molecules on Human Brain Microvascular Endothelial Cells Regulate Leukocyte Adhesion and Modulate Permeability of the In Vitro Blood-Brain Barrier Model

Autor: Saguna Verma, Beverly Orillo, Kelsey Roe

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 7, p e102598 (2014)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e025503761a9137084adf0617ba5c7ae
https://doi.org/10.1371/journal.pone.0102598

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Expression of triggering receptor expressed on myeloid cells-1 (TREM-1) is up-regulated following West Nile virus infection (WNV): implication for a role in innate immune responses (VIR1P.968)

Autor: Saguna Verma, Kelsey Roe, Beverly Orillo, Jacob Nelson, Sebastien Gibot

Publikováno v: The Journal of Immunology. 192:74.10-74.10

Activation of TREM-1 signaling via adaptor protein DAP12 is important for inflammation and activation of antigen presenting cells, however little is known about its role in viral infections. Innate immune responses are essential for the control of Fl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17d6342f64aaaa3cd31aa5bc856af24d
https://doi.org/10.4049/jimmunol.192.supp.74.10

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Expression of TREM-1 is triggered by flaviviruses: possible role in virus-associated innate immune responses (P1381)

Autor: Kelsey Roe, Jacob Nelson, Beverly Orillo, Saguna Verma

Publikováno v: The Journal of Immunology. 190:57.2-57.2

Activation of Triggering Receptor Expressed on Myeloid cells 1 (TREM-1), an immunoreceptor expressed mainly on immune cells results in a cascade of inflammatory effects including cytokine production. In addition, TREM-1 also modulates signaling casca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56cf5e1ce13a40be809ccd1ef9d2294a
https://doi.org/10.4049/jimmunol.190.supp.57.2

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Reduced immune cells infiltration and increased neuroinflammation in type 2 diabetic mice infected with West Nile virus (P6038)

Autor: Mukesh Kumar, Kelsey Roe, Pratibha Nerurkar, Beverly Orillo, Saguna Verma, Vivek Nerurkar

Publikováno v: The Journal of Immunology. 190:49.2-49.2

Diabetes is a significant risk factor for developing West Nile virus (WNV)-associated encephalitis (WNVE) in humans. Using a diabetic mouse model, db/db, we recently demonstrated that diabetes enhanced WNV replication and susceptibility of mice to WN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b291e2b609a1c315f820f1989535389
https://doi.org/10.4049/jimmunol.190.supp.49.2

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