Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Beverly Norris"'
Autor:
Zhijun Guo, Jianxun Lei, Hrishi Venkatesh, David Owen, Adam Bass, Christine Cannon, Joshua McCarra, Brenda Koniar, Craig Flory, Beverly Norris, Robert J. Schumacher, Swaathi Jayaraman, John Hawse, Emmanuel S. Antonarakis, Emanuel F. Petricoin, Julia Wulfkuhle, Robert D. Cardiff, Elizabeth A. Ambrose, Gunda I. Georg, Kaylee L. Schwertfeger, Michael A. Farrar, Brad St. Croix, Matthew P. Goetz, David A. Potter
Publikováno v:
Cancer Research. 83:LB102-LB102
Introduction: Immune checkpoint blockade (ICB) has clinical activity in triple negative breast cancer (TNBC) but is less effective in the ER+HER2- signature, where there is a cold immune microenvironment (IM) and regulatory T cells (Tregs) may suppre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0eca3e0a3cd4f4500c719dc7c528f07e
https://doi.org/10.1158/1538-7445.am2023-lb102
https://doi.org/10.1158/1538-7445.am2023-lb102
Autor:
Robert J. Schumacher, Nicole Larson, Timothy P. Rich, Margaret A. Mysz, Beverly Norris, Lia G. Coicou, Brenda Koniar, Craig M. Flory, David H. Ingbar
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics
Acute respiratory distress syndrome (ARDS) is a severe, life-threatening form of respiratory failure characterized by pulmonary edema, inflammation, and hypoxemia due to reduced alveolar fluid clearance (AFC). Alveolar fluid clearance is required for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f2a269f70740b8bf0edf12a61aee0a
https://pubmed.ncbi.nlm.nih.gov/33127750
https://pubmed.ncbi.nlm.nih.gov/33127750
Autor:
Hiroshi Hiasa, Delaney E Hart, Sarah R.C. Lentz, Tyrell R. Towle, Lisa M. Oppegard, Robert J. Kerns, Justine L. Delgado, Beverly Norris, Chaitanya A. Kulkarni, Craig M. Flory, Daryl J. Murry, Bridget P. Williams, Robert J. Schumacher
Publikováno v:
Investigational New Drugs. 37:378-383
Fluoroquinolone-class agents selectively target the bacterial type IIA topoisomerases DNA gyrase and topoisomerase IV, with a few exceptions that target eukaryotic type IIA topoisomerases. Fluoroquinolones bind and stabilize type IIA topoisomerase-DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b318fbf452cb83f75309803c081e217
https://doi.org/10.1007/s10637-018-0666-x
https://doi.org/10.1007/s10637-018-0666-x
Autor:
Jianxun Lei, Gunda I. Georg, Matthew P. Goetz, David Potter, Beverly Norris, Ilia G. Denisov, Stephen Sliga, Robert J. Schumacher, John R. Hawse, Swaathi Jayaraman, Irina F. Sevrioukova, Zhijun Guo, Tom Poulos, Craig M. Flory, Connor M. McDermott, Kwon Ho Hong, Elizabeth A. Ambrose
Publikováno v:
Cancer Research. 81:LB078-LB078
Introduction: Small molecule therapeutics of estrogen receptor-positive/HER2-negative breast cancer remains an area of active investigation where novel agents are greatly needed for treatment of hormone therapy resistant metastatic disease. The bigua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b213dbc6768e2f9bc51db9d869a0694e
https://doi.org/10.1158/1538-7445.am2021-lb078
https://doi.org/10.1158/1538-7445.am2021-lb078
Autor:
Robert J. Schumacher, Anannya Banga, James R. Dutton, Jakub Tolar, Margaret A. Mysz, Beverly Norris, Brenda M. Ogle, Craig M. Flory
Publikováno v:
Journal of Stem Cell Research & Therapy.
Differentiation of adult stem/progenitor cells into functional beta cells to provide a successful autologous cell therapy for Type 1 diabetes patients has not yet been achieved. Progenitor cells in the adult pancreas or liver have been considered pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48f90dc6ac3aa57fbaaa25b49058a724
https://doi.org/10.4172/2157-7633.1000432
https://doi.org/10.4172/2157-7633.1000432
Autor:
Beverly Norris, Rebecca A. D. Cuellar, Satish Patil, Robert J. Schumacher, Bruce R. Blazar, Lev G Lis, Raj Suryanarayanan, Vadim J. Gurvich, Monique Morgan, Gunda I. Georg
Publikováno v:
Journal of Medicinal Chemistry
A disodium phosphonooxymethyl prodrug of the antitumor agent triptolide was prepared from the natural product in three steps (39% yield) and displayed excellent aqueous solubility at pH 7.4 (61 mg/mL) compared to the natural product (17 μg/mL). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d70ac155da712a5c54c8738d17c028
https://doi.org/10.1021/acs.jmedchem.5b01329
https://doi.org/10.1021/acs.jmedchem.5b01329
Autor:
John E. Wagner, Bruce R. Blazar, Beverly Norris, Robert J. Schumacher, Heather E. Stefanski, Juan Carlos Zúñiga-Pflücker, Jastaranpreet Singh
Publikováno v:
Biology of Blood and Marrow Transplantation. 24:S425-S426
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2fa708e993cb52885da376e71b8fea3
https://doi.org/10.1016/j.bbmt.2017.12.434
https://doi.org/10.1016/j.bbmt.2017.12.434
Autor:
Griffin, Beverly Norris
Publikováno v:
Journal of Reading, 1982 Jan 01. 25(4), 371-372.
Externí odkaz:
https://www.jstor.org/stable/40030389
Autor:
Ting Lan Chiu, Young Kyung Bae, Craig M. Flory, Yelena V. Grinkova, Ameeta Kelekar, Stephen G. Sligar, M. Gerard O'Sullivan, Adela Galván, Irina F. Sevrioukova, Kalpna Gupta, Beverly Norris, Ian A. Blair, Elizabeth A. Ambrose, Fernando Luna, Ilia G. Denisov, John D. Lipscomb, Eric A. Hanse, Haitao Chu, Daniel S. Swedien, Robert J. Schumacher, William M. Atkins, Rebecca A. D. Cuellar, Gunda I. Georg, Julia Wulfkuhle, Zhijun Guo, Rosa I. Gallagher, Thomas L. Poulos, Qing Cao, Vanessa Wankhede Langenfeld, Xia Zhang, John R. Falck, Juan Alvarez, Emanuel F. Petricoin, Dafydd G. Thomas, Jorge H. Capdevila, David Potter, Justin D. Stamschror
Publikováno v:
Cell Chemical Biology. 24:1259-1275.e6
The mechanisms by which cancer cell-intrinsic CYP monooxygenases promote tumor progression are largely unknown. CYP3A4 was unexpectedly associated with breast cancer mitochondria and synthesized arachidonic acid (AA)-derived epoxyeicosatrienoic acids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609abd584fa3973a5ec9c305d29ee4dd
https://doi.org/10.1016/j.chembiol.2017.08.009
https://doi.org/10.1016/j.chembiol.2017.08.009
Autor:
Robert J. Schumacher, Jeffrey P. Jones, Irina F. Sevrioukova, Zhijun Guo, Robin L. Bliss, Daniel S. Swedien, Rebecca A. D. Cuellar, Kalpna Gupta, Eric A. Hanse, Dafydd G. Thomas, Ian A. Blair, John R. Falck, Ilia G. Denisov, Michael J. Maher, William Marerro Ortiz, William M. Atkins, Haitao Chu, Monique Morgan, Elizabeth A. Amin, Thomas L. Poulos, Stephen C. Schmechel, Gunda I. Georg, Jorge H. Capdevila, Young Kyung Bae, Stephen G. Sligar, Jonathan Henriksen, Ting-Lan Chiu, Beverly Norris, Juan Alvarez, Ameeta Kelekar, Xia Zhang, David Potter, Justin D. Stamschror, Henry Wang, Kathryn J. Chavez
Publikováno v:
Cancer Research. 75:3568-3568
While cytochrome P450 enzymes (CYPs) are implicated in tumor angiogenesis through biosynthesis of epoxyeicosatrienoic acids (EETs), little is known about breast cancer cell-intrinsic CYPs that exhibit epoxygenase activity, such as CYP3A4. In an ortho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe3224cd84742e53c6d16d82a86f3893
https://doi.org/10.1158/1538-7445.am2015-3568
https://doi.org/10.1158/1538-7445.am2015-3568