Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Beverly Knight"'
Autor:
Anne M. Fourie, Xiaoli Cheng, Leon Chang, Carrie Greving, Xinyi Li, Beverly Knight, David Polidori, Aaron Patrick, Trpta Bains, Ruth Steele, Samantha J. Allen, Raymond J. Patch, Chengzao Sun, Sandeep Somani, Ashok Bhandari, David Liu, Keith Huie, Shu Li, Michael A. Rodriguez, Xiaohua Xue, Arun Kannan, Teddy Kosoglou, Jonathan P. Sherlock, Jennifer Towne, M. Claire Holland, Nishit B. Modi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The interleukin (IL)-23 pathway is a pathogenic driver in psoriasis, psoriatic arthritis, and inflammatory bowel disease. Currently, no oral therapeutics selectively target this pathway. JNJ-77242113 is a peptide targeting the IL-23 receptor
Externí odkaz:
https://doaj.org/article/a5c225b49e4844578be75fc534d1282c
Publikováno v:
Cancer Medicine, Vol 12, Iss 17, Pp 17981-17992 (2023)
Abstract Background The BELA and BFORE trials compared bosutinib starting doses of 500 mg once daily (QD) and 400 mg QD, respectively, with imatinib in adults with newly diagnosed chronic phase chronic myeloid leukemia (CP‐CML). The B1871048 trial
Externí odkaz:
https://doaj.org/article/493c3a6c69c04e3d879accda6962802b
Autor:
Mark Sabat, Douglas R Dougan, Beverly Knight, J. David Lawson, Nicholas Scorah, Christopher R Smith, Ewan R Taylor, Phong Vu, Corey Wyrick, Haixia Wang, Deepika Balakrishna, Mark Hixon, Loui Madakamutil, Donavon McConn
Publikováno v:
Journal of Medicinal Chemistry. 64:12893-12902
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3f8b9b1a52718a454e07ddda041d931
https://doi.org/10.1021/acs.jmedchem.1c01026
https://doi.org/10.1021/acs.jmedchem.1c01026
Autor:
Beverly Knight, Jennifer E. Hibma
Publikováno v:
Clinical Pharmacokinetics. 58:335-347
Gemtuzumab ozogamicin is an antibody–drug conjugate composed of the anti-CD33 monoclonal antibody hP67.6 covalently linked to N-acetyl-gamma-calicheamicin dimethylhydrazide, a potent cytotoxic antibiotic. The aim of this study was to characterize t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fc06d2810403f313c668541300117e
https://doi.org/10.1007/s40262-018-0699-5
https://doi.org/10.1007/s40262-018-0699-5
Autor:
Loui Madakamutil, Ewan Taylor, Phong H. Vu, Mark Sabat, Deepika Balakrishna, Beverly Knight, Haixia Wang, Corey Wyrick, Mark S. Hixon, Nicholas Scorah, Christopher Ronald Smith, Donavon McConn, Petro Halkowycz, Douglas R. Dougan, J. David Lawson, Jacques Ermolieff
Publikováno v:
Journal of Medicinal Chemistry. 64:16318-16318
This publication details the successful use of FBDD (fragment-based drug discovery) principles in the invention of a novel covalent Bruton's tyrosine kinase inhibitor, which ultimately became the Takeda Pharmaceuticals clinical candidate TAK-020. Des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77e890954972cb077d4fa384cc9189ca
https://doi.org/10.1021/acs.jmedchem.1c01685
https://doi.org/10.1021/acs.jmedchem.1c01685
Publikováno v:
Clinical pharmacokinetics. 58(2)
To date, the population pharmacokinetics (popPK) of gemtuzumab ozogamicin (GO), a CD33-directed antibody–drug conjugate consisting of hP67.6 antibody linked to N-acetyl gamma calicheamicin used in the treatment of acute myeloid leukemia (AML), has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008dc94aea1158f56c45e39045e32560
https://pubmed.ncbi.nlm.nih.gov/30022367
https://pubmed.ncbi.nlm.nih.gov/30022367
Publikováno v:
Cancer Chemotherapy and Pharmacology
Purpose This study compared the pharmacokinetics of PF-06439535, a potential bevacizumab biosimilar, to bevacizumab sourced from the European Union (bevacizumab-EU) and USA (bevacizumab-US), and of bevacizumab-EU to bevacizumab-US. Methods In this do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::842f884139421b3207d464e6f5795e48
https://pubmed.ncbi.nlm.nih.gov/26984210
https://pubmed.ncbi.nlm.nih.gov/26984210
Autor:
Beverly Knight
Publikováno v:
The Contemporary Pacific. 26:viii-553
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::541b6f9a01618a0132fa59854319626c
https://doi.org/10.1353/cp.2014.0036
https://doi.org/10.1353/cp.2014.0036
Autor:
Christopher R. Smith, DouglasR. Dougan, Mallareddy Komandla, Toufike Kanouni, Beverly Knight, J. David Lawson, Mark Sabat, Ewan R. Taylor, Phong Vu, Corey Wyrick
Publikováno v:
Journal of Medicinal Chemistry; Jul2015, Vol. 58 Issue 14, p5437-5444, 8p
Autor:
Fuchs GJ 3rd; Department of Pediatrics, University of Kentucky College of Medicine and Department of Epidemiology, University of Kentucky College of Public Health, Lexington, Kentucky., Abrams SA; Department of Pediatrics, Dell Medical School at the University of Texas at Austin, Austin, Texas., Amevor AA; Beverly Knight Olsen Children's Hospital, Atrium Health, Macon, Georgia.
Publikováno v:
Pediatrics [Pediatrics] 2023 Nov 01; Vol. 152 (5).