Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Beverly H. Koller"'
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113852- (2024)
Summary: The NLRP3 inflammasome is essential for caspase-1 activation and the release of interleukin (IL)-1β, IL-18, and gasdermin-D in myeloid cells. However, research on species-specific NLRP3’s physiological impact is limited. We engineer mice
Externí odkaz:
https://doaj.org/article/73a3933d8dcb417398db4efc4f97a270
Autor:
Christelle Douillet, Madison Miller, Peter H. Cable, Qing Shi, Hisham El-Masri, Tomáš Matoušek, Beverly H. Koller, David J. Thomas, Miroslav Stýblo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Although mice are widely used to study adverse effects of inorganic arsenic (iAs), higher rates of iAs methylation in mice than in humans may limit their utility as a model organism. A recently created 129S6 mouse strain in which the Borcs7/
Externí odkaz:
https://doaj.org/article/95a8b550989e4ae5bfc2097fe9026ca2
Autor:
Ting Yang, Chengcheng Song, Donna L. Ralph, Portia Andrews, Matthew A. Sparks, Beverly H. Koller, Alicia A. McDonough, Thomas M. Coffman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 19 (2022)
Background A beneficial role for prostanoids in hypertension is suggested by clinical studies showing nonsteroidal anti‐inflammatory drugs, which block the production of all prostanoids, cause sodium retention and exacerbate hypertension. Among pro
Externí odkaz:
https://doaj.org/article/1e745101eca4475590b2c265fe58e7d5
Autor:
Eva Conde, Romain Bertrand, Bianca Balbino, Jonathan Bonnefoy, Julien Stackowicz, Noémie Caillot, Fabien Colaone, Samir Hamdi, Raïssa Houmadi, Alexia Loste, Jasper B. J. Kamphuis, François Huetz, Laurent Guilleminault, Nicolas Gaudenzio, Aurélie Mougel, David Hardy, John N. Snouwaert, Beverly H. Koller, Vincent Serra, Pierre Bruhns, Géraldine Grouard-Vogel, Laurent L. Reber
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Asthma is caused by hyperreactivity to benign antigens, with humoral immunity orchestrated by interleukin-4 (IL-4) and IL-13 being the key etiological factor. Here the authors show, in humanized mouse models, that dual vaccination against IL-4 and IL
Externí odkaz:
https://doaj.org/article/aa43d94c3b9c4cd69ba35a1d0034149e
Autor:
Farideh Shafiee-Kermani, Skyla T. Carney, Dereje Jima, Utibe C. Utin, LaNeisha B. Farrar, Melvin O. Oputa, Marcono R. Hines, H. Karimi Kinyamu, Kevin W. Trotter, Trevor K. Archer, Cathrine Hoyo, Beverly H. Koller, Stephen J. Freedland, Delores J. Grant
Publikováno v:
Epigenetics, Vol 16, Iss 3, Pp 289-299 (2021)
Studies have suggested that abrogated expression of detoxification enzymes, UGT2B15 and UGT2B17, are associated with prostate tumour risk and progression. We investigated the role of EGF on the expression of these enzymes since it interacts with sign
Externí odkaz:
https://doaj.org/article/b07d19108d254966ae0dcb681885e3bb
Autor:
Marcela Herrera, Ting Yang, Matthew A. Sparks, Michael W. Manning, Beverly H. Koller, Thomas M. Coffman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 4 (2019)
Background Prostaglandin E2 (PGE2) is a major prostanoid with multiple actions that potentially affect blood pressure (BP). PGE2 acts through 4 distinct E‐prostanoid (EP) receptor isoforms: EP1 to EP4. The EP4 receptor (EP4R) promotes PGE2‐depend
Externí odkaz:
https://doaj.org/article/f7d64efdd52a489fa7749f4cd67dbbb2
Autor:
Subhashini Chandrasekharan, Nicholas A. Foley, Leigh Jania, Patsy Clark, Laurent P. Audoly, Beverly H. Koller
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 12, Pp 2636-2648 (2005)
The mammary gland, like most tissues, produces measurable amounts of prostaglandin E2 (PGE2), a metabolite of arachidonic acid produced by sequential actions of two cyclooxygenases (COX-1 and COX-2) and three terminal PGE synthases: microsomal prosta
Externí odkaz:
https://doaj.org/article/2944ba4c8b344af0a55914cc3d54b93a
Autor:
Gezahegn Gorfu, Kimberly M. Cirelli, Mariane B. Melo, Katrin Mayer-Barber, Devorah Crown, Beverly H. Koller, Seth Masters, Alan Sher, Stephen H. Leppla, Mahtab Moayeri, Jeroen P. J. Saeij, Michael E. Grigg
Publikováno v:
mBio, Vol 5, Iss 1 (2014)
ABSTRACT Induction of immunity that limits Toxoplasma gondii infection in mice is critically dependent on the activation of the innate immune response. In this study, we investigated the role of cytoplasmic nucleotide-binding domain and leucine-rich
Externí odkaz:
https://doaj.org/article/0e46b702f63e4b6498962218d8a787d3
Autor:
Beverly H. Koller, John N. Snouwaert, Adam M. Speen, Alexia Perryman, Ilona Jaspers, Jessica R. Hoffman, Hye-Young H. Kim, Ned A. Porter, William Rivera Martin, Phillip W. Clapp
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 65:500-512
Ozone (O3) is a prevalent air pollutant causing lung inflammation. Previous studies demonstrate that O3 oxidizes lipids, such as cholesterol, in the airway to produce oxysterols, such as secosterol...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d25dd65a10ef2bfcfb50d62e78e8930c
https://doi.org/10.1165/rcmb.2021-0032oc
https://doi.org/10.1165/rcmb.2021-0032oc
Autor:
Gabriele Matschiner, Mary F. Fitzgerald, Ulrich Moebius, Andreas M. Hohlbaum, Hendrik Gille, Kristian Jensen, Klaus Kirchfeld, Barbara Rattenstetter, Alice Laforge, Rachida S. Bel Aiba, Joe Ciccotosto, Hong Nyugen, Martyn L. Foster, John N. Snouwaert, MyTrang Nguyen, Beverly H. Koller, Louis Matis, Gary P. Anderson, Shane A. Olwill
Publikováno v:
The Journal of allergy and clinical immunology.
T2 endotype asthma is driven by IL-4 and IL-13 signaling via IL-4Ra, which is highly expressed on airway epithelium, airway smooth muscle and immunocytes in the respiratory mucosa, suggesting potential advantages of an inhalable antagonist. Lipocalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7453cf58f638e882136c65f31dd25509
https://pubmed.ncbi.nlm.nih.gov/36592703
https://pubmed.ncbi.nlm.nih.gov/36592703