Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Beverly H Koller"'
Autor:
John N Snouwaert, Leigh A Jania, Trang Nguyen, David R Martinez, Alexandra Schäfer, Nicholas J Catanzaro, Kendra L Gully, Ralph S Baric, Mark Heise, Martin T Ferris, Elizabeth Anderson, Katia Pressey, Jacob A Dillard, Sharon Taft-Benz, Victoria K Baxter, Jenny P-Y Ting, Beverly H Koller
Publikováno v:
PLoS Pathogens, Vol 19, Iss 2, p e1011168 (2023)
Angiotensin-converting enzyme 2 (ACE2), part of the renin-angiotensin system (RAS), serves as an entry point for SARS-CoV-2, leading to viral proliferation in permissive cell types. Using mouse lines in which the Ace2 locus has been humanized by synt
Externí odkaz:
https://doaj.org/article/75be0b479d294111a5b725cdfbedb42c
Autor:
Kelsey A Behrens, Leigh A Jania, John N Snouwaert, MyTrang Nguyen, Sheryl S Moy, Andrey P Tikunov, Jeffrey M Macdonald, Beverly H Koller
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225449 (2019)
Environmental and endogenous electrophiles cause tissue damage through their high reactivity with endogenous nucleophiles such as DNA, proteins, and lipids. Protection against damage is mediated by glutathione (GSH) conjugation, which can occur spont
Externí odkaz:
https://doaj.org/article/3bfefc70a31c4aed8966846980f44286
Autor:
Martina Kovarova, Beverly H Koller
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102948 (2014)
Increased mast cell numbers are observed at sites of allergic inflammation and restoration of normal mast cell numbers is critical to the resolution of these responses. Early studies showed that cytokines protect mast cells from apoptosis, suggesting
Externí odkaz:
https://doaj.org/article/d9bb4b68a3df4a07ac7d9323c2f6d77e
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e51105 (2012)
Familial Mediterranean Fever (FMF) is an inherited autoinflammatory disorder characterized by unprovoked episodes of fever and inflammation. The associated gene, MEFV (Mediterranean Fever), is expressed primarily by cells of myeloid lineage and encod
Externí odkaz:
https://doaj.org/article/c98b689ea1194271b66df3aa814a1aa7
Autor:
Christelle Douillet, Madison Miller, Peter H. Cable, Qing Shi, Hisham El-Masri, Tomáš Matoušek, Beverly H. Koller, David J. Thomas, Miroslav Stýblo
Publikováno v:
Scientific Reports. 13
Although mice are widely used to study adverse effects of inorganic arsenic (iAs), higher rates of iAs methylation in mice than in humans may limit their utility as a model organism. A recently created 129S6 mouse strain in which the Borcs7/As3mt loc
Autor:
Marcela Herrera, Ting Yang, Matthew A. Sparks, Michael W. Manning, Beverly H. Koller, Thomas M. Coffman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 4 (2019)
Background Prostaglandin E2 (PGE2) is a major prostanoid with multiple actions that potentially affect blood pressure (BP). PGE2 acts through 4 distinct E‐prostanoid (EP) receptor isoforms: EP1 to EP4. The EP4 receptor (EP4R) promotes PGE2‐depend
Externí odkaz:
https://doaj.org/article/f7d64efdd52a489fa7749f4cd67dbbb2
Autor:
Beverly H. Koller, John N. Snouwaert, Adam M. Speen, Alexia Perryman, Ilona Jaspers, Jessica R. Hoffman, Hye-Young H. Kim, Ned A. Porter, William Rivera Martin, Phillip W. Clapp
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 65:500-512
Ozone (O3) is a prevalent air pollutant causing lung inflammation. Previous studies demonstrate that O3 oxidizes lipids, such as cholesterol, in the airway to produce oxysterols, such as secosterol...
Autor:
Ting Yang, Chengcheng Song, Donna L. Ralph, Portia Andrews, Matthew A. Sparks, Beverly H. Koller, Alicia A. McDonough, Thomas M. Coffman
Publikováno v:
Journal of the American Heart Association. 11
Background A beneficial role for prostanoids in hypertension is suggested by clinical studies showing nonsteroidal anti‐inflammatory drugs, which block the production of all prostanoids, cause sodium retention and exacerbate hypertension. Among pro
Autor:
Gabriele Matschiner, Mary F. Fitzgerald, Ulrich Moebius, Andreas M. Hohlbaum, Hendrik Gille, Kristian Jensen, Klaus Kirchfeld, Barbara Rattenstetter, Alice Laforge, Rachida S. Bel Aiba, Joe Ciccotosto, Hong Nyugen, Martyn L. Foster, John N. Snouwaert, MyTrang Nguyen, Beverly H. Koller, Louis Matis, Gary P. Anderson, Shane A. Olwill
Publikováno v:
The Journal of allergy and clinical immunology.
T2 endotype asthma is driven by IL-4 and IL-13 signaling via IL-4Ra, which is highly expressed on airway epithelium, airway smooth muscle and immunocytes in the respiratory mucosa, suggesting potential advantages of an inhalable antagonist. Lipocalin
Autor:
Cathrine Hoyo, Delores J Grant, Farideh Shafiee-Kermani, Dereje D. Jima, H. Karimi Kinyamu, Stephen J. Freedland, Beverly H. Koller, Kevin W. Trotter, LaNeisha B Farrar, Trevor K. Archer, Marcono R Hines, Skyla T. Carney, Melvin O Oputa, Utibe C Utin
Publikováno v:
Epigenetics. 16:289-299
Studies have suggested that abrogated expression of detoxification enzymes, UGT2B15 and UGT2B17, are associated with prostate tumour risk and progression. We investigated the role of EGF on the expression of these enzymes since it interacts with sign