Zobrazeno 1 - 10
of 199
pro vyhledávání: '"Beverly H, Koller"'
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113852- (2024)
Summary: The NLRP3 inflammasome is essential for caspase-1 activation and the release of interleukin (IL)-1β, IL-18, and gasdermin-D in myeloid cells. However, research on species-specific NLRP3’s physiological impact is limited. We engineer mice
Externí odkaz:
https://doaj.org/article/73a3933d8dcb417398db4efc4f97a270
Autor:
Christelle Douillet, Madison Miller, Peter H. Cable, Qing Shi, Hisham El-Masri, Tomáš Matoušek, Beverly H. Koller, David J. Thomas, Miroslav Stýblo
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Although mice are widely used to study adverse effects of inorganic arsenic (iAs), higher rates of iAs methylation in mice than in humans may limit their utility as a model organism. A recently created 129S6 mouse strain in which the Borcs7/
Externí odkaz:
https://doaj.org/article/95a8b550989e4ae5bfc2097fe9026ca2
Autor:
John N Snouwaert, Leigh A Jania, Trang Nguyen, David R Martinez, Alexandra Schäfer, Nicholas J Catanzaro, Kendra L Gully, Ralph S Baric, Mark Heise, Martin T Ferris, Elizabeth Anderson, Katia Pressey, Jacob A Dillard, Sharon Taft-Benz, Victoria K Baxter, Jenny P-Y Ting, Beverly H Koller
Publikováno v:
PLoS Pathogens, Vol 19, Iss 2, p e1011168 (2023)
Angiotensin-converting enzyme 2 (ACE2), part of the renin-angiotensin system (RAS), serves as an entry point for SARS-CoV-2, leading to viral proliferation in permissive cell types. Using mouse lines in which the Ace2 locus has been humanized by synt
Externí odkaz:
https://doaj.org/article/75be0b479d294111a5b725cdfbedb42c
Autor:
Ting Yang, Chengcheng Song, Donna L. Ralph, Portia Andrews, Matthew A. Sparks, Beverly H. Koller, Alicia A. McDonough, Thomas M. Coffman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 19 (2022)
Background A beneficial role for prostanoids in hypertension is suggested by clinical studies showing nonsteroidal anti‐inflammatory drugs, which block the production of all prostanoids, cause sodium retention and exacerbate hypertension. Among pro
Externí odkaz:
https://doaj.org/article/1e745101eca4475590b2c265fe58e7d5
Autor:
Eva Conde, Romain Bertrand, Bianca Balbino, Jonathan Bonnefoy, Julien Stackowicz, Noémie Caillot, Fabien Colaone, Samir Hamdi, Raïssa Houmadi, Alexia Loste, Jasper B. J. Kamphuis, François Huetz, Laurent Guilleminault, Nicolas Gaudenzio, Aurélie Mougel, David Hardy, John N. Snouwaert, Beverly H. Koller, Vincent Serra, Pierre Bruhns, Géraldine Grouard-Vogel, Laurent L. Reber
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Asthma is caused by hyperreactivity to benign antigens, with humoral immunity orchestrated by interleukin-4 (IL-4) and IL-13 being the key etiological factor. Here the authors show, in humanized mouse models, that dual vaccination against IL-4 and IL
Externí odkaz:
https://doaj.org/article/aa43d94c3b9c4cd69ba35a1d0034149e
Autor:
Farideh Shafiee-Kermani, Skyla T. Carney, Dereje Jima, Utibe C. Utin, LaNeisha B. Farrar, Melvin O. Oputa, Marcono R. Hines, H. Karimi Kinyamu, Kevin W. Trotter, Trevor K. Archer, Cathrine Hoyo, Beverly H. Koller, Stephen J. Freedland, Delores J. Grant
Publikováno v:
Epigenetics, Vol 16, Iss 3, Pp 289-299 (2021)
Studies have suggested that abrogated expression of detoxification enzymes, UGT2B15 and UGT2B17, are associated with prostate tumour risk and progression. We investigated the role of EGF on the expression of these enzymes since it interacts with sign
Externí odkaz:
https://doaj.org/article/b07d19108d254966ae0dcb681885e3bb
Autor:
Marcela Herrera, Ting Yang, Matthew A. Sparks, Michael W. Manning, Beverly H. Koller, Thomas M. Coffman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 4 (2019)
Background Prostaglandin E2 (PGE2) is a major prostanoid with multiple actions that potentially affect blood pressure (BP). PGE2 acts through 4 distinct E‐prostanoid (EP) receptor isoforms: EP1 to EP4. The EP4 receptor (EP4R) promotes PGE2‐depend
Externí odkaz:
https://doaj.org/article/f7d64efdd52a489fa7749f4cd67dbbb2
Autor:
Kelsey A Behrens, Leigh A Jania, John N Snouwaert, MyTrang Nguyen, Sheryl S Moy, Andrey P Tikunov, Jeffrey M Macdonald, Beverly H Koller
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225449 (2019)
Environmental and endogenous electrophiles cause tissue damage through their high reactivity with endogenous nucleophiles such as DNA, proteins, and lipids. Protection against damage is mediated by glutathione (GSH) conjugation, which can occur spont
Externí odkaz:
https://doaj.org/article/3bfefc70a31c4aed8966846980f44286
Autor:
Beverly H. Koller, John N. Snouwaert, Adam M. Speen, Alexia Perryman, Ilona Jaspers, Jessica R. Hoffman, Hye-Young H. Kim, Ned A. Porter, William Rivera Martin, Phillip W. Clapp
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 65:500-512
Ozone (O3) is a prevalent air pollutant causing lung inflammation. Previous studies demonstrate that O3 oxidizes lipids, such as cholesterol, in the airway to produce oxysterols, such as secosterol...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d25dd65a10ef2bfcfb50d62e78e8930c
https://doi.org/10.1165/rcmb.2021-0032oc
https://doi.org/10.1165/rcmb.2021-0032oc
Autor:
Gabriele Matschiner, Mary F. Fitzgerald, Ulrich Moebius, Andreas M. Hohlbaum, Hendrik Gille, Kristian Jensen, Klaus Kirchfeld, Barbara Rattenstetter, Alice Laforge, Rachida S. Bel Aiba, Joe Ciccotosto, Hong Nyugen, Martyn L. Foster, John N. Snouwaert, MyTrang Nguyen, Beverly H. Koller, Louis Matis, Gary P. Anderson, Shane A. Olwill
Publikováno v:
The Journal of allergy and clinical immunology.
T2 endotype asthma is driven by IL-4 and IL-13 signaling via IL-4Ra, which is highly expressed on airway epithelium, airway smooth muscle and immunocytes in the respiratory mucosa, suggesting potential advantages of an inhalable antagonist. Lipocalin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7453cf58f638e882136c65f31dd25509
https://pubmed.ncbi.nlm.nih.gov/36592703
https://pubmed.ncbi.nlm.nih.gov/36592703