Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Beverly D. Smolich"'
Autor:
Julie M. Cherrington, Alyssa Morimoto, Beverly D. Smolich, Grant A. McArthur, Nguyen Tan, Kristina A. West, William C. Manning, Guy C. Toner
Publikováno v:
Oncogene. 23:1618-1626
Biomarkers that indicate biological activity and/or efficacy are a potentially useful tool in the development of molecularly targeted therapeutics. It is useful, though challenging, to identify biomarkers during preclinical development in order to im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c8bea5488cb9f30b7edb98f69b98c23
https://doi.org/10.1038/sj.onc.1207268
https://doi.org/10.1038/sj.onc.1207268
Autor:
Francis J. Giles, Beverly D. Smolich, Kristina A. West, Julie M. Cherrington, Helene A. Yuen, Maher Albitar
Publikováno v:
Blood. 97:1413-1421
SU5416 and SU6668 are potent antiangiogenic small-molecule inhibitors of receptor tyrosine kinases, including those of the vascular endothelial growth factor and platelet-derived growth factor receptor families. The stem cell factor (SCF) receptor, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44c5b5024c401a59fa5a46c73f3831a5
https://doi.org/10.1182/blood.v97.5.1413
https://doi.org/10.1182/blood.v97.5.1413
Publikováno v:
Journal of Biochemistry. 121:382-388
We have isolated human and rat clones of the LIM motif-containing protein kinase, termed LIMK-2. LIMK-2 is related to the neuronally expressed LIM-kinase, whose hemizygous deletion appears to result in cognitive impairment in patients with Williams s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7b683a4e94e0ca6269247b2de7c9292
https://doi.org/10.1093/oxfordjournals.jbchem.a021599
https://doi.org/10.1093/oxfordjournals.jbchem.a021599
Autor:
Beverly D. Smolich, Jackie Papkoff
Publikováno v:
Developmental Biology. 166:300-310
The P19 embryonal carcinoma (EC) cell line represents a useful model system for analysis of neural development and differentiation processes that are difficult to study in mammalian embryos. Since many members of the Wnt family of signaling molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480496c0780d222e6f5669fb2a6d234a
https://doi.org/10.1006/dbio.1994.1316
https://doi.org/10.1006/dbio.1994.1316
Autor:
Diana J. Griffith, Laura McGreevey, Cecily L. Wait, Gerald McMahon, Beverly D. Smolich, Michael Heinrich, Anne Marie O'Farrell, Julie M. Cherrington, Kevin W.H. Yee
Publikováno v:
Blood. 100(8)
Internal tandem duplication (ITD) in the juxtamembrane portion of Fms-like tyrosine kinase 3 (FLT3), a type III receptor tyrosine kinase (RTK), is the most common molecular defect associated with acute myeloid leukemia (AML). The high prevalence of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6835bbd7565ac6eb7ac309a8366c6a8
https://pubmed.ncbi.nlm.nih.gov/12351406
https://pubmed.ncbi.nlm.nih.gov/12351406
Autor:
Beverly D. Smolich, John W. Taylor
Publikováno v:
Current Genetics. 9:597-603
To provide for thorough sampling of the Neurospora crassa mitochondrial genome for evolutionary studies, recombinant plasmids containing each of the EcoRI digestion fragments of the genome were assembled and used to map the locations of 89 additional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc5318f56fdbcb2c43044d0f33a960b
https://doi.org/10.1007/bf00381173
https://doi.org/10.1007/bf00381173
Publikováno v:
Molecular and General Genetics MGG. 201:161-167
We have discovered a mitochondrial DNA plasmid in N. crassa 516 (Roanoke, LA) which is homologous to those previously described from N. intermedia 435 (Fiji) and N. tetrasperma 2510 (Hanalei, HA). Subsequent analysis by DNA-DNA hybridization showed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fda96b2620bc5aed5f1dba0603c2bcd
https://doi.org/10.1007/bf00425654
https://doi.org/10.1007/bf00425654
Publikováno v:
Evolution. 40:716-739
We studied mitochondrial DNA variability in 19 natural Neurospora crassa isolates and one wild-type isolate to examine evolution of these fungi and their mitochondrial DNA (mtDNA). We combined restriction endonuclease analysis of natural isolate mtDN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c21476f80e23f5222dfd4ca5c4a11f
https://doi.org/10.1111/j.1558-5646.1986.tb00533.x
https://doi.org/10.1111/j.1558-5646.1986.tb00533.x
Autor:
Anne-Marie O'Farrell, Samuel Deprimo, Lily Wong, Deepak B. Khatry, William C. Manning, Beverly D. Smolich, Susan L Nicholas, Julie M. Cherrington
Publikováno v:
BMC Cancer
BMC Cancer, Vol 3, Iss 1, p 3 (2003)
BMC Cancer, Vol 3, Iss 1, p 3 (2003)
Background Microarray-based gene expression profiling is a powerful approach for the identification of molecular biomarkers of disease, particularly in human cancers. Utility of this approach to measure responses to therapy is less well established,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a05a80424fe6da94b4469cd504bc4dd
Autor:
DePrimo, Samuel E.1 samuel-deprimo@sugen.com, Wong, Lily M.1 lily-wong@sugen.com, Khatry, Deepak B.2 deepakkhatry@sugen.com, Nicholas, Susan L.1 susan-nicholas@sugen.com, Manning, William c.1 bill-manning@sugen.com, Smolich, Beverly D.1 beverly-smolich@sugen.com, O'Farrell, Anne-Marie1 marie-ofarrell@sugen.com, Cherrington, Julie M.1 juliecherrington@sugen.com
Publikováno v:
BMC Cancer. 2003, Vol. 3, p3-12. 12p. 2 Diagrams, 5 Charts, 2 Graphs.