Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Beverly A. Leslie"'
Autor:
Paul Y. Kim, Calvin H. Yeh, Brian J. Dale, Beverly A. Leslie, Alan R. Stafford, James C. Fredenburgh, Jack Hirsh, Jeffrey I. Weitz
Publikováno v:
TH Open, Vol 02, Iss 02, Pp e190-e201 (2018)
Rivaroxaban and apixaban are both small molecules that reversibly inhibit factor Xa. Compared with rivaroxaban, apixaban has minimal effects on the prothrombin time and activated partial thromboplastin time. To investigate this phenomenon, we used a
Externí odkaz:
https://doaj.org/article/4f047f8b39114affb255507bb976a3e4
Autor:
Alan R. Stafford, Jeffrey I. Weitz, Paul Y. Kim, Calvin H. Yeh, James C. Fredenburgh, Brian Dale, Jack Hirsh, Beverly A. Leslie
Publikováno v:
TH Open: Companion Journal to Thrombosis and Haemostasis
TH Open, Vol 02, Iss 02, Pp e190-e201 (2018)
TH Open, Vol 02, Iss 02, Pp e190-e201 (2018)
Rivaroxaban and apixaban are both small molecules that reversibly inhibit factor Xa. Compared with rivaroxaban, apixaban has minimal effects on the prothrombin time and activated partial thromboplastin time. To investigate this phenomenon, we used a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a294114d0be7a41c33c32c43be27ee8
https://pubmed.ncbi.nlm.nih.gov/31249942
https://pubmed.ncbi.nlm.nih.gov/31249942
Autor:
Trang T. Vu, Nima Vaezzadeh, James C. Fredenburgh, Ran Ni, Brett P. Monia, Jeffrey I. Weitz, Ji Zhou, Alan R. Stafford, Peter L. Gross, Willi Jahnen-Dechent, Beverly A. Leslie, Shengjun Qiao
Publikováno v:
Blood. 125:2712-2719
Factor (F) XII, a key component of the contact system, triggers clotting via the intrinsic pathway, and is implicated in propagating thrombosis. Although nucleic acids are potent activators, it is unclear how the contact system is regulated to preven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55de28e0e698a18c4fa1d6a5bb1abb75
https://doi.org/10.1182/blood-2014-11-611319
https://doi.org/10.1182/blood-2014-11-611319
Autor:
Paul Y. Kim, Jeffrey I. Weitz, Trang T. Vu, Alan R. Stafford, Beverly A. Leslie, James C. Fredenburgh
Publikováno v:
Journal of Biological Chemistry. 289:27494-27503
Fibrin (Fn) clots formed from γ'-fibrinogen (γ'-Fg), a variant with an elongated γ-chain, are resistant to lysis when compared with clots formed from the predominant γA-Fg, a finding previously attributed to differences in clot structure due to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065fc35901e8624a474636ae1c13ebec
https://doi.org/10.1074/jbc.m114.588640
https://doi.org/10.1074/jbc.m114.588640
Autor:
Beverly A. Leslie, Teresa Lim, Howard H.W. Chan, James C. Fredenburgh, Alan R. Stafford, Jeffrey I. Weitz
Publikováno v:
Journal of Biological Chemistry. 288:29394-29402
The nonspecific binding of heparin to plasma proteins compromises its anticoagulant activity by reducing the amount of heparin available to bind antithrombin. In addition, interaction of heparin with fibrin promotes formation of a ternary heparin-thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9e5a29aca2073da1364ba5e6e160e2
https://doi.org/10.1074/jbc.m113.469916
https://doi.org/10.1074/jbc.m113.469916
Autor:
Beverly A. Leslie, Louise Jawerth, David A. Weitz, Ben Fabry, Jeffrey I. Weitz, Stefan Münster
Publikováno v:
Proceedings of the National Academy of Sciences. 110:12197-12202
We show that the nonlinear mechanical response of networks formed from un–cross-linked fibrin or collagen type I continually changes in response to repeated large-strain loading. We demonstrate that this dynamic evolution of the mechanical response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5497726b795d9117bb801b36a87f254c
https://doi.org/10.1073/pnas.1222787110
https://doi.org/10.1073/pnas.1222787110
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 6, p e0157471 (2016)
PLoS ONE, Vol 11, Iss 6, p e0157471 (2016)
Thrombin is a highly plastic molecule whose activity and specificity are regulated by exosites 1 and 2, positively-charged domains that flank the active site. Exosite binding by substrates and cofactors regulates thrombin activity by localizing throm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9340109ea5a33d902111691d52088eb
http://europepmc.org/articles/PMC4909201
http://europepmc.org/articles/PMC4909201
Autor:
Robin S. Roberts, Howard H.W. Chan, Beverly A. Leslie, Alan R. Stafford, James C. Fredenburgh, Jeffrey I. Weitz, Nadine N Al-Aswad
Publikováno v:
Biochemistry. 51:7964-7973
Heparin binds fibrin and, by bridging thrombin onto fibrin, promotes the formation of a ternary heparin-thrombin-fibrin complex that protects thrombin from inhibition by antithrombin. Because thrombin binds γ(A)/γ'-fibrin, a variant with an extende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5819677aec4caa02ebedfb90ace1180f
https://doi.org/10.1021/bi301046b
https://doi.org/10.1021/bi301046b
Autor:
Huayin Wu, Jeffrey I. Weitz, Sara J. Henderson, Beverly A. Leslie, David A. Weitz, Jing Xia, James C. Fredenburgh, Alan R. Stafford
Publikováno v:
Thrombosis and haemostasis. 115(3)
SummaryZinc released from activated platelets binds fibrin(ogen) and attenuates fibrinolysis. Although zinc also affects clot formation, the mechanism and consequences are poorly understood. To address these gaps, the effect of zinc on clot formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c72e5e5ee6afa5a11863ce38e675f5e
https://pubmed.ncbi.nlm.nih.gov/26489782
https://pubmed.ncbi.nlm.nih.gov/26489782
Autor:
Alan R. Stafford, Jeffrey I. Weitz, Ji Zhou, James C. Fredenburgh, Trang T. Vu, Beverly A. Leslie
Publikováno v:
Thrombosis and haemostasis. 115(1)
SummaryWhen triggered by factor (F) XII and nucleic acids, we showed that thrombosis in HRG-deficient mice is accelerated compared with that in wild-type mice. In this study, we set out to identify the mechanisms by which nucleic acids promote contac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::010c377e379738a6e28237ffd62ff3fb
https://pubmed.ncbi.nlm.nih.gov/26354857
https://pubmed.ncbi.nlm.nih.gov/26354857