Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Beverly A. Baptiste"'
Autor:
Cecily Choy, Joseph Chen, Jiangyuan Li, D. Travis Gallagher, Jian Lu, Daichao Wu, Ainslee Zou, Humza Hemani, Beverly A. Baptiste, Emily Wichmann, Qian Yang, Jeffrey Ciffelo, Rui Yin, Julia McKelvy, Denise Melvin, Tonya Wallace, Christopher Dunn, Cuong Nguyen, Chee W. Chia, Jinshui Fan, Jeannie Ruffolo, Linda Zukley, Guixin Shi, Tomokazu Amano, Yang An, Osorio Meirelles, Wells W. Wu, Chao-Kai Chou, Rong-Fong Shen, Richard A. Willis, Minoru S. H. Ko, Yu-Tsueng Liu, Supriyo De, Brian G. Pierce, Luigi Ferrucci, Josephine Egan, Roy Mariuzza, Nan-Ping Weng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract The resolution of SARS-CoV-2 replication hinges on cell-mediated immunity, wherein CD8+ T cells play a vital role. Nonetheless, the characterization of the specificity and TCR composition of CD8+ T cells targeting non-spike protein of SARS-C
Externí odkaz:
https://doaj.org/article/963224e732b44fa8b3d0805dabc27063
Publikováno v:
Nucleic Acids Res
Cockayne syndrome (CS) is a segmental premature aging syndrome caused primarily by defects in the CSA or CSB genes. In addition to premature aging, CS patients typically exhibit microcephaly, progressive mental and sensorial retardation and cutaneous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b56c2f68546c87fa3b195a513cf683b
https://europepmc.org/articles/PMC7968995/
https://europepmc.org/articles/PMC7968995/
Autor:
Mansoor Hussain, Vilhelm A. Bohr, Sudarshan Krishnamurthy, Edward W Kim, Jaimin Patel, Beverly A. Baptiste, Deborah L. Croteau
Publikováno v:
J Invest Dermatol
Defects in DNA repair pathways and alterations of mitochondrial energy metabolism have been reported in multiple skin disorders. More than 10% of patients with primary mitochondrial dysfunction exhibit dermatological features including rashes and hai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d752a0928b60cf77748a62d6dc8979a
https://pubmed.ncbi.nlm.nih.gov/33353663
https://pubmed.ncbi.nlm.nih.gov/33353663
Autor:
Stephanie L. Baringer, Deborah L. Croteau, Beverly A. Baptiste, Tomasz Kulikowicz, Robert M. Brosh, Vilhelm A. Bohr, Joshua A. Sommers
Publikováno v:
DNA Repair (Amst)
DNA polymerase beta (POLβ), well known for its role in nuclear DNA base excision repair (BER), has been shown to be present in the mitochondria of several different cell types. Here we present a side-by-side comparison of BER activities of POLβ and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1cbbeb4d3ae7cf5c2a3c7545bbdb78
https://pubmed.ncbi.nlm.nih.gov/33540226
https://pubmed.ncbi.nlm.nih.gov/33540226
Neurodegeneration results in devastating illnesses with few effective treatments. Mitochondrial dysfunction has been associated with several neurodegenerative diseases. Neurons are highly energetic cells and rely heavily on healthy mitochondria. Much
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::654b5a97e3bdedbdd95ad1eea017e7e3
https://doi.org/10.1039/9781839162541-00129
https://doi.org/10.1039/9781839162541-00129
Autor:
Vilhelm A. Bohr, Beverly A. Baptiste, Deborah L. Croteau, William L. Rumsey, Elayne M. Fivenson, Steven R. Katchur
Publikováno v:
Free Radical Biology and Medicine. 124:149-162
The common oxidatively generated lesion, 8-oxo-7,8-dihydroguanine (8-oxoGua), is removed from DNA by base excision repair. The glycosylase primarily charged with recognition and removal of this lesion is 8-oxoGuaDNA glycosylase 1 (OGG1). When left un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80cd82d1f8dd090674aa555c2ab2f584
https://doi.org/10.1016/j.freeradbiomed.2018.05.094
https://doi.org/10.1016/j.freeradbiomed.2018.05.094
Autor:
Stephanie Cordonnier, Mark P. Mattson, Dong Liu, Beverly A. Baptiste, Magdalena Misiak, Deborah L. Croteau, Peter Sykora, Rebeca Vergara Greeno, Vilhelm A. Bohr, Evandro Fei Fang
Publikováno v:
Aging Cell
Summary Alzheimer's disease (AD) involves the progressive degeneration of neurons critical for learning and memory. In addition, patients with AD typically exhibit impaired olfaction associated with neuronal degeneration in the olfactory bulb (OB). B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3a7bc783534f1d6378123ef7f4145eb
https://doi.org/10.1111/acel.12541
https://doi.org/10.1111/acel.12541
Autor:
Deborah L. Croteau, Eduardo Zavala, Yongqing Zhang, Tinna Stevnsner, Sofie Lautrup, Yujun Hou, Yue Wang, Jennifer F. O’Connell, Kanako Moritoh, Beverly A. Baptiste, Vilhelm A. Bohr, Mark P. Mattson, Stephanie Cordonnier
Publikováno v:
Hou, Y, Lautrup, S, Cordonnier, S, Wang, Y, Croteau, D L, Zavala, E, Zhang, Y, Moritoh, K, O'Connell, J F, Baptiste, B A, Stevnsner, T V, Mattson, M P & Bohr, V A 2018, ' NAD + supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency ', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 8, pp. E1876-E1885 . https://doi.org/10.1073/pnas.1718819115
Emerging findings suggest that compromised cellular bioenergetics and DNA repair contribute to the pathogenesis of Alzheimer’s disease (AD), but their role in disease-defining pathology is unclear. We developed a DNA repair-deficient 3xTgAD/Polβ +
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddad78c9337fa5342427d9f16607e873
https://pure.au.dk/portal/da/publications/nad-supplementation-normalizes-key-alzheimers-features-and-dna-damage-responses-in-a-new-ad-mouse-model-with-introduced-dna-repair-deficiency(746d2162-47e6-4c35-96ad-bb8e0e081dcd).html
https://pure.au.dk/portal/da/publications/nad-supplementation-normalizes-key-alzheimers-features-and-dna-damage-responses-in-a-new-ad-mouse-model-with-introduced-dna-repair-deficiency(746d2162-47e6-4c35-96ad-bb8e0e081dcd).html
Autor:
Yujun, Hou, Sofie, Lautrup, Stephanie, Cordonnier, Yue, Wang, Deborah L, Croteau, Eduardo, Zavala, Yongqing, Zhang, Kanako, Moritoh, Jennifer F, O'Connell, Beverly A, Baptiste, Tinna V, Stevnsner, Mark P, Mattson, Vilhelm A, Bohr
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(8)
Alzheimer’s disease (AD) is the most common form of dementia, and there is no cure. DNA repair activity is deficient in AD patient brains, especially DNA polymerase β (Polβ), a key protein in DNA base excision. NAD+ is a cellular metabolite criti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::117a2f9769680651a6c4e8a73b289bdb
https://pubmed.ncbi.nlm.nih.gov/29432159
https://pubmed.ncbi.nlm.nih.gov/29432159
Autor:
Deborah L. Croteau, Dong Liu, Mark P. Mattson, Yongqing Zhang, David M. Wilson, Jane Tian, Soumya Chigurupati, Evandro Fei Fang, Beverly A. Baptiste, Peter Sykora, Kevin G. Becker, Vilhelm A. Bohr, Yue Wang, Somnath Ghosh, Wei Na Cong, Magdalena Misiak, Giovana S. Leandro, Boris M. Brenerman, Royce J. Hamilton, Josephine M. Egan
Publikováno v:
Nucleic Acids Research
We explore the role of DNA damage processing in the progression of cognitive decline by creating a new mouse model. The new model is a cross of a common Alzheimer's disease (AD) mouse (3xTgAD), with a mouse that is heterozygous for the critical DNA b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c09e4d19417c065448e4b348e428b625
http://europepmc.org/articles/PMC4333403
http://europepmc.org/articles/PMC4333403