Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Beverly A Tinkelenberg"'
Publikováno v:
Experimental Cell Research. 287:39-46
dUTP nucleotidohydrolase (dUTPase) catalyzes the hydrolysis of dUTP to dUMP and pyrophosphate and is the central regulator of cellular dUTP pools. Nuclear (DUT-N) and mitochondrial (DUT-M) isoforms of the protein have been identified in humans and ar
Autor:
Beverly A Tinkelenberg, Sal Caradonna, Michael J Hansbury, Robert D. Ladner, Imane Elateri, Susan Muller-Weeks
Publikováno v:
DNA Repair. 2:315-323
There are at least four distinct families of enzymes that recognize and remove uracil from DNA. Family-3 (SMUG1) enzymes have recently been identified and have a preference for uracil in single-stranded DNA when assayed in vitro. Here we investigate
Publikováno v:
Cancer research. 62(17)
The thymidylate synthase reaction remains an important target for widely used anticancer agents; however, the clinical utility of these drugs is limited by the occurrence of cellular resistance. Despite the considerable amount of information availabl