Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Beverly, Holskin"'
Autor:
Rabindranath, Tripathy, Robert J, McHugh, Edward R, Bacon, Joseph M, Salvino, George C, Morton, Lisa D, Aimone, Zeck, Huang, Joanne R, Mathiasen, Amy, DiCamillo, Mark J, Huffman, Beth A, McKenna, Karla, Kopec, Lily D, Lu, Jie, Qian, Thelma S, Angeles, Thomas, Connors, Chrysanthe, Spais, Beverly, Holskin, Emir, Duzic, Hervé, Schaffhauser, Gerard C, Rossé
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(3)
Serotoninergic neurotransmission has been implicated in modulation of learning and memory. It has been demonstrated that 5-hydroxytryptamine(6) (5-HT(6)) receptor antagonists show beneficial effect on cognition in several animal models. Based on a ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bbd67be491fa50904fc04fc20c374a04
https://pubmed.ncbi.nlm.nih.gov/22226656
https://pubmed.ncbi.nlm.nih.gov/22226656
Autor:
Babu G, Sundar, Thomas R, Bailey, Derek D, Dunn, Edward R, Bacon, Joseph M, Salvino, George C, Morton, Lisa D, Aimone, Huang, Zeqi, Joanne R, Mathiasen, Amy, Dicamillo, Mark J, Huffman, Beth A, McKenna, Karla, Kopec, Lily D, Lu, Rebecca, Brown, Jie, Qian, Thelma, Angeles, Thomas, Connors, Chrysanthe, Spais, Beverly, Holskin, Deborah, Galinis, Emir, Duzic, Herve, Schaffhauser, Gerard C, Rosse
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(1)
7-Arylsulfonyl substituted benzofuropiperidine was discovered as a novel scaffold for 5HT(6) receptor antagonists. Optimization by substitution at C-1 position led to identification of selective, orally bioavailable, brain penetrant antagonists with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b0ab8369735ed85da9712148db21027
https://pubmed.ncbi.nlm.nih.gov/22153937
https://pubmed.ncbi.nlm.nih.gov/22153937
Autor:
Beverly Holskin, James E. Strickler, Paul J. Johnson, David Shalloway, Mann-Jy Chen, Joselina G. Gorniak, Michelle Mitcho, Mike A. Clark
Publikováno v:
Nature. 330:581-583
Tumour necrosis factor alpha (ref. 1), synthesized primarily by monocytes in response to various invasive agents, induces a wide variety of biological effects relevant to regulating cell growth and differentiation, including the selective killing of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e2b6248782ddb6c8ae7649440b6d2ad
https://doi.org/10.1038/330581a0
https://doi.org/10.1038/330581a0