Cohort Profile: East London Genes & Health (ELGH), a community based population genomics and health study of British-Bangladeshi and British-Pakistani people

Autor: Zaheer Ahmed, Ahsan Nabi Khan, Richard C. Trembath, David A. van Heel, Sarah Finer, Beverley MacLaughlin, Chris Griffiths, Hilary C. Martin, Richard Ashcroft, Ceri Durham, John Robson, Karen A. Hunt, Daniel G. MacArthur, Bhavi Trivedi, Mark I. McCarthy, John Wright

Publikováno v: International Journal of Epidemiology

Cohort profile in a nutshellEast London Genes & Health (ELGH) is a large scale, community genomics and health study (to date >34,000 volunteers; target 100,000 volunteers).ELGH was set up in 2015 to gain deeper understanding of health and disease, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d913727bbdcfed886b90a4bc8ed4cd53

Prevalence, determinants and clinical correlates of vitamin D deficiency in adults with inhaled corticosteroid-treated asthma in London, UK

Autor: Beverley MacLaughlin, Aklak Choudhury, Kate Kilpin, Christopher Corrigan, Adrian R. Martineau, Claire L. Greiller, Peter Timms, Chris Griffiths, Richard Hooper, Neil Barnes, Raj K Rajakulasingam, Robert Walton, Elina Hyppönen, David A. Jolliffe, Angshu Bhowmik, David E. Simcock

Publikováno v: Jolliffe, D A, Kilpin, K, MacLaughlin, B D, Greiller, C L, Hooper, R L, Barnes, N C, Timms, P M, Rajakulasingam, R K, Bhowmik, A, Choudhury, A B, Simcock, D E, Hyppönen, E, Corrigan, C J, Walton, R T, Griffiths, C J & Martineau, A R 2016, ' Prevalence, determinants and clinical correlates of vitamin D deficiency in adults with inhaled corticosteroid-treated asthma in London, UK ', Journal of Steroid Biochemistry and Molecular Biology . https://doi.org/10.1016/j.jsbmb.2016.11.004

Vitamin D deficiency is common in children with asthma, and it associates with poor asthma control, reduced forced expiratory volume in one second (FEV1) and increased requirement for inhaled corticosteroids (ICS). Cross-sectional studies investigati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1097482740278a2f86ef8c76e3c0dd9d
https://kclpure.kcl.ac.uk/ws/files/58981506/1_s2.0_S0960076016303004_main.pdf

Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3 supplementation in adults with asthma (ViDiAs)

Autor: Kate Kilpin, David McLaughlin, Chris Griffiths, Richard Hooper, Robert Walton, Neil Barnes, Gareth Fletcher, W Monteiro, Raj K Rajakulasingam, Angshu Bhowmik, Aklak Choudhury, David E. Simcock, Catherine M. Hawrylowicz, Peter Timms, Marion Rowe, David A. Jolliffe, Claire L. Greiller, Timothy R Venton, Zia Sadique, Mimoza Hoti, Charles A. Mein, Christopher Corrigan, Beverley MacLaughlin, Adrian R. Martineau, Jonathan Grigg

Publikováno v: Thorax. 70(5)

Rationale Asthma exacerbations are commonly precipitated by viral upper respiratory infections (URIs). Vitamin D insufficiency associates with susceptibility to URI in patients with asthma. Trials of vitamin D in adults with asthma with incidence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40089890226b34664625d89acfc0dbcb
https://pubmed.ncbi.nlm.nih.gov/25724847