Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Beverley M. Dancy"'
Autor:
Philip A. Cole, Beverley M. Dancy
Publikováno v:
Chemical Reviews
Since their discovery in the 1980s and 1990s, the human protein lysine acetyltransferase encoded by the paralogous p300 and CBP genes has received much interest. p300/CBP functions in regulating the expression of genes controlling several basic cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1244d1f039a73b12c4687736be603f7
https://doi.org/10.1021/cr500452k
https://doi.org/10.1021/cr500452k
Publikováno v:
Frontiers in Bioscience. 20:198-228
Simple multicellular animal model systems are central to studying the complex mechanisms underlying a bewildering array of diseases involving dysfunctional mitochondria. Mutant nuclear- and mitochondrial-encoded subunits of the Caenorhabditis elegans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151757be49a9922e3fe094113b260a38
https://doi.org/10.2741/4305
https://doi.org/10.2741/4305
Publikováno v:
Experimental Gerontology. 56:245-255
How an organism ages is a question that has fascinated biologists, and the elderly, for centuries. One useful approach to understanding complex processes such as aging is to study genetic variation in model organisms such as the nematode, Caenorhabdi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f8effef903be0b480cadd93100a7e6
https://doi.org/10.1016/j.exger.2014.03.028
https://doi.org/10.1016/j.exger.2014.03.028
Autor:
David J. Meyers, Erin M. Bowers, Beverley M. Dancy, Young Hoon Ahn, Philip A. Cole, Chandrani Mukherjee, Jin Zhang, Daniel J. Peterson, Nicholas T. Crump, Minoru Yoshida, Jef D. Boeke, Louis C. Mahadevan
Publikováno v:
ChemBioChem. 13:2113-2121
Histone acetyltransferase enzymes (HATs) are important therapeutic targets, but there are few cell-based assays available for evaluating the pharmacodynamics of HAT inhibitors. Here we present the application of a FRET-based reporter, Histac, in live
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e01bc28d971e1acf1f02bb64498c4dc
https://doi.org/10.1002/cbic.201200381
https://doi.org/10.1002/cbic.201200381
Identification of Targets of c-Src Tyrosine Kinase by Chemical Complementation and Phosphoproteomics
Autor:
Jin Zhang, Harrys K.C. Jacob, Ron Bose, Isabel Martinez Ferrando, Katie J. Herbst-Robinson, Beverley M. Dancy, Akhilesh Pandey, Vikram Katju, Raghothama Chaerkady, Philip A. Cole, Jun Zhong, Henrik Molina
Publikováno v:
Molecular & Cellular Proteomics. 11:355-369
The cellular proto-oncogene c-Src is a nonreceptor tyrosine kinase involved in cell growth and cytoskeletal regulation. Despite being dysregulated in a variety of human cancers, its precise functions are not fully understood. Identification of the su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590f62d5a422f9d4029c6adae8079dc1
https://doi.org/10.1074/mcp.m111.015750
https://doi.org/10.1074/mcp.m111.015750
Autor:
Ananya Majumdar, Robert J. Cotter, William J. Drury, Beverley M. Dancy, Yan Sun, Christine A. Jelinek, Philip A. Cole, Romeo Papazyan, Shonoi Ming, Blair C. R. Dancy, Sean D. Taverna
Publikováno v:
Journal of the American Chemical Society. 134:5138-5148
Reversible lysine acetylation and methylation regulate the function of a wide variety of proteins, including histones. Here, we have synthesized azalysine-containing peptides in acetylated and unacetylated forms as chemical probes of the histone deac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1234c6b306b13b4f4d760dc4d74ad571
https://doi.org/10.1021/ja209574z
https://doi.org/10.1021/ja209574z
Autor:
Mikael J. Lindberg, Anita E. Popko-Ścibor, Beverley M. Dancy, Mariana Saint Just Ribeiro, Philip A. Cole, Annika E. Wallberg, Magnus L. Hansson
Publikováno v:
Nucleic Acids Research
MAML1 is a transcriptional coregulator originally identified as a Notch coactivator. MAML1 is also reported to interact with other coregulator proteins, such as CDK8 and p300, to modulate the activity of Notch. We, and others, previously showed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c41b7d72876cfcd241edcfb174d5395
http://europepmc.org/articles/PMC2685096
http://europepmc.org/articles/PMC2685096
Autor:
Beverley M. Dancy, Yoing Yang, Margaret M. Sedensky, Renjini Ramadasan-Nair, Philip G. Morgan, Nicole L Brockway
Publikováno v:
Mechanisms of ageing and development. 153
To understand primary mitochondrial disease, we utilized a complex I-deficient Caenorhabditis elegans mutant, gas-1. These animals strongly upregulate the expression of gst-14 (encoding a glutathione S-transferase). Knockdown of gst-14 dramatically e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f91ff21d0fead5e5476f9f66b5a6fa
https://pubmed.ncbi.nlm.nih.gov/26704446
https://pubmed.ncbi.nlm.nih.gov/26704446
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1857:e22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2732fe3a366218de88e30526f24e39ab
https://doi.org/10.1016/j.bbabio.2016.04.045
https://doi.org/10.1016/j.bbabio.2016.04.045
Autor:
Beverley M. Dancy, Philip A. Cole
Publikováno v:
Chemical Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe2ac2cbbf285c670c3551d1a94f9bf
http://europepmc.org/articles/PMC8314858
http://europepmc.org/articles/PMC8314858