Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Beverley Fermor"'
Publikováno v:
Osteoarthritis and Cartilage. 18:1167-1173
Summary Objective Increased pro-inflammatory cytokines and reactive oxygen and nitrogen species (RONS) occur in osteoarthritis (OA). Oxygen tension can alter the levels of RONS induced by interleukin-1 (IL-1). RONS such as nitric oxide (NO) can alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd5da6efd75b80c9a5463a169610293
https://doi.org/10.1016/j.joca.2010.06.004
https://doi.org/10.1016/j.joca.2010.06.004
Publikováno v:
Journal of Cellular Physiology. 217:828-833
Osteoarthritis (OA) is associated with increased levels of reactive oxygen species. This study investigated if increased oxidative DNA damage accumulates in OA articular cartilage compared with non-OA articular cartilage from pigs with spontaneous OA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be5a2dbe707b079b5f17d188f585ddce
https://doi.org/10.1002/jcp.21562
https://doi.org/10.1002/jcp.21562
Publikováno v:
Osteoarthritis and Cartilage. 16:624-630
SummaryObjectiveOsteoarthritis (OA) is associated with increased levels of reactive nitrogen and oxygen species and pro-inflammatory cytokines, such as interleukin-1 (IL-1). Nitric oxide (NO) can mediate a number of the catabolic effects of IL-1 in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d95e45d53c0d2200be887e7dab3d576
https://doi.org/10.1016/j.joca.2007.09.012
https://doi.org/10.1016/j.joca.2007.09.012
Autor:
Farshid Guilak, Jeffrey M. Gimble, Qiongfang Cao, Hani A. Awad, Kristen E. Lott, Beverley Fermor, Kevin C. Hicok
Publikováno v:
Journal of Cellular Physiology. 206:229-237
Pools of human adipose-derived adult stem (hADAS) cells can exhibit multiple differentiated phenotypes under appropriate in vitro culture conditions. Because adipose tissue is abundant and easily accessible, hADAS cells offer a promising source of ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6d218e6a0e05c89c9d228a4959e2351
https://doi.org/10.1002/jcp.20463
https://doi.org/10.1002/jcp.20463
Publikováno v:
Journal of Cellular Physiology. 204:184-191
Articular cartilage is an avascular connective tissue that exhibits little intrinsic capacity for repair. Articular cartilage exists in a reduced oxygen (∼5%) environment in vivo; therefore, oxygen tension may be an important factor that regulates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595b8d46de5733c47c4398d780e13ba9
https://doi.org/10.1002/jcp.20324
https://doi.org/10.1002/jcp.20324
Autor:
J. Brice Weinberg, Alfred Hennerbichler, David S. Pisetsky, Beverley Fermor, Devon Jeffcoat, Farshid Guilak
Publikováno v:
Osteoarthritis and Cartilage. 12(12):956-962
Summary Objectives Cells of the knee meniscus respond to changes in their biochemical and biomechanical environments with alterations in the biosynthesis of matrix constituents and inflammatory mediators. Tumor necrosis factor alpha (TNF-α) is a pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7566b29231f1664a0a188df36d1fbda4
Autor:
Lori A. Setton, Farshid Guilak, Francis J. Keefe, Beverley Fermor, David S. Pisetsky, Virginia B. Kraus, J. Brice Weinberg, Steven A. Olson
Publikováno v:
Clinical Orthopaedics & Related Research. 423:17-26
Osteoarthritis is a painful and debilitating disease characterized by progressive degenerative changes in the articular cartilage and other joint tissues. Biomechanical factors play a critical role in the initiation and progression of this disease, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a841ac2ef145615b9513295611dd538f
https://doi.org/10.1097/01.blo.0000131233.83640.91
https://doi.org/10.1097/01.blo.0000131233.83640.91
Autor:
Christian Fink, Farshid Guilak, J B Weinberg, Mary A. Misukonis, Beverley Fermor, David S. Pisetsky
Publikováno v:
Osteoarthritis and Cartilage. 10:792-798
Objective Biomechanical signals play important roles in regulating the homeostasis of articular cartilage, but under abnormal conditions may be a critical factor in the onset and progression of arthritis. Prostaglandin E 2 (PGE 2 ) and nitric oxide (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1cb7b9c97ce62395e96a3e5fb3fec7
https://doi.org/10.1053/joca.2002.0832
https://doi.org/10.1053/joca.2002.0832
Publikováno v:
Biochemical and Biophysical Research Communications. 285:806-810
Nitric oxide (NO) and leukotrienes regulate a variety of processes in joint tissues and are frequently elevated in arthritis. Mechanical stress can induce biochemical and functional changes in cartilage that may influence mediator production. To inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24e14f71d80e736dd0a74121bfb057e
https://doi.org/10.1006/bbrc.2001.5237
https://doi.org/10.1006/bbrc.2001.5237
Autor:
Alexander LeGrand, J. Brice Weinberg, Farshid Guilak, T. Parker Vail, Beverley Fermor, Christian Fink, David S. Pisetsky
Publikováno v:
Arthritis & Rheumatism. 44:2078-2083
Objective In osteoarthritis (OA), a combination of biochemical and biomechanical factors may damage both menisci and articular cartilage. Nitric oxide (NO) and prostaglandin E2 (PGE2) have been implicated as mediators of inflammation in OA. The goals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8e4fd4d93eda82f93a7fd3e406859b9
https://doi.org/10.1002/1529-0131(200109)44:9<2078::aid-art358>3.0.co
https://doi.org/10.1002/1529-0131(200109)44:9<2078::aid-art358>3.0.co