Comparison of Toxicities among Different Bumped Kinase Inhibitor Analogs for Treatment of Cryptosporidiosis.

Autor: Hulverson MA; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, Washington, USA., Choi R; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, Washington, USA., Schaefer DA; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA., Betzer DP; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA., McCloskey MC; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, Washington, USA., Whitman GR; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, Washington, USA., Huang W; Department of Biochemistry, University of Washington, Seattle, Washington, USA., Lee S; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA., Pranata A; Research School of Chemistry, Australian National University, Canberra, ACT, Australia., McLeod MD; Research School of Chemistry, Australian National University, Canberra, ACT, Australia., Marsh KC; Research and Development, AbbVie, Inc., North Chicago, Illinois, USA., Kempf DJ; Research and Development, AbbVie, Inc., North Chicago, Illinois, USA.; Former employee of AbbVie, Inc., North Chicago, Illinois, USA., LeRoy BE; Research and Development, AbbVie, Inc., North Chicago, Illinois, USA., Zafiratos MT; Research and Development, AbbVie, Inc., North Chicago, Illinois, USA., Bielinski AL; Research and Development, AbbVie, Inc., North Chicago, Illinois, USA., Hackman RC; Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.; Department of Pathology, University of Washington, Seattle, Washington, USA.; Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA., Ojo KK; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, Washington, USA., Arnold SLM; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, Washington, USA., Barrett LK; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, Washington, USA., Tzipori S; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA., Riggs MW; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, Arizona, USA., Fan E; Department of Biochemistry, University of Washington, Seattle, Washington, USA., Van Voorhis WC; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, Washington, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2023 Apr 18; Vol. 67 (4), pp. e0142522. Date of Electronic Publication: 2023 Mar 15.

One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases.

Autor: Van Voorhis WC; Center for Emerging and Re-emerging Infectious Diseases (CERID), Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, 98109, USA. Electronic address: wesley@uw.edu., Hulverson MA; Center for Emerging and Re-emerging Infectious Diseases (CERID), Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, 98109, USA., Choi R; Center for Emerging and Re-emerging Infectious Diseases (CERID), Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, 98109, USA., Huang W; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA., Arnold SLM; Center for Emerging and Re-emerging Infectious Diseases (CERID), Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, 98109, USA., Schaefer DA; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, 85721, USA., Betzer DP; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, 85721, USA., Vidadala RSR; Department of Chemistry, University of Washington, Seattle, WA, 98195, USA., Lee S; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA, 01536, USA., Whitman GR; Center for Emerging and Re-emerging Infectious Diseases (CERID), Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, 98109, USA., Barrett LK; Center for Emerging and Re-emerging Infectious Diseases (CERID), Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, 98109, USA., Maly DJ; Department of Chemistry, University of Washington, Seattle, WA, 98195, USA., Riggs MW; School of Animal and Comparative Biomedical Sciences, University of Arizona, Tucson, AZ, 85721, USA., Fan E; Department of Biochemistry, University of Washington, Seattle, WA, 98195, USA., Kennedy TJ; Eleven Bravo LLC, Westport, WI, 53597, USA., Tzipori S; Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA, 01536, USA., Doggett JS; Oregon Health & Science University, Portland, OR, 97239, USA., Winzer P; Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland., Anghel N; Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland., Imhof D; Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland., Müller J; Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland., Hemphill A; Institute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland., Ferre I; Saluvet, Animal Health Department, Faculty of Veterinary Sciences, Complutense University of Madrid, Ciudad Universitaria s/n, 28040, Madrid, Spain., Sanchez-Sanchez R; Saluvet, Animal Health Department, Faculty of Veterinary Sciences, Complutense University of Madrid, Ciudad Universitaria s/n, 28040, Madrid, Spain., Ortega-Mora LM; Saluvet, Animal Health Department, Faculty of Veterinary Sciences, Complutense University of Madrid, Ciudad Universitaria s/n, 28040, Madrid, Spain., Ojo KK; Center for Emerging and Re-emerging Infectious Diseases (CERID), Department of Medicine, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA, 98109, USA.

Publikováno v: Veterinary parasitology [Vet Parasitol] 2021 Jan; Vol. 289, pp. 109336. Date of Electronic Publication: 2020 Dec 15.

Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis.

Autor: Hulverson MA; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, WA 98109, USA., Choi R; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, WA 98109, USA., Arnold SLM; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, WA 98109, USA., Schaefer DA; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ 85721, USA., Hemphill A; Institute of Parasitology, Vetsuisse Faculty, University of Bern, Länggass-Strasse 122, CH-3012 Bern, Switzerland., McCloskey MC; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, WA 98109, USA., Betzer DP; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ 85721, USA., Müller J; Institute of Parasitology, Vetsuisse Faculty, University of Bern, Länggass-Strasse 122, CH-3012 Bern, Switzerland., Vidadala RSR; Department of Chemistry, University of Washington, Seattle, WA 98195, USA., Whitman GR; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, WA 98109, USA., Rivas KL; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, WA 98109, USA., Barrett LK; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, WA 98109, USA., Hackman RC; Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Pathology, University of Washington, Seattle, WA 98195, USA; Department of Laboratory Medicine, University of Washington, Seattle, WA 98195, USA., Love MS; California Institute for Biomedical Research, La Jolla, CA, USA., McNamara CW; California Institute for Biomedical Research, La Jolla, CA, USA., Shaughnessy TK; Research and Development, AbbVie, Inc, North Chicago, IL 60064, USA., Kondratiuk A; Research and Development, AbbVie, Inc, North Chicago, IL 60064, USA., Kurnick M; Research and Development, AbbVie, Inc, North Chicago, IL 60064, USA., Banfor PN; Research and Development, AbbVie, Inc, North Chicago, IL 60064, USA., Lynch JJ; Research and Development, AbbVie, Inc, North Chicago, IL 60064, USA., Freiberg GM; Research and Development, AbbVie, Inc, North Chicago, IL 60064, USA., Kempf DJ; Research and Development, AbbVie, Inc, North Chicago, IL 60064, USA., Maly DJ; Department of Chemistry, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA., Riggs MW; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ 85721, USA., Ojo KK; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, WA 98109, USA. Electronic address: ojo67kk@u.washington.edu., Van Voorhis WC; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease (CERID), University of Washington, Seattle, WA 98109, USA. Electronic address: wesley@uw.edu.

Publikováno v: International journal for parasitology [Int J Parasitol] 2017 Oct; Vol. 47 (12), pp. 753-763. Date of Electronic Publication: 2017 Sep 09.

Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis.

Autor: Schaefer DA; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson., Betzer DP; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson., Smith KD; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson., Millman ZG; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson., Michalski HC; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson., Menchaca SE; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson., Zambriski JA; Paul G. Allen School for Global Animal Health, College of Veterinary Medicine, Washington State University, Pullman., Ojo KK; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease., Hulverson MA; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease., Arnold SL; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease., Rivas KL; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease., Vidadala RS; Department of Chemistry., Huang W; Department of Biochemistry, University of Washington, Seattle., Barrett LK; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease., Maly DJ; Department of Chemistry.; Department of Biochemistry, University of Washington, Seattle., Fan E; Department of Biochemistry, University of Washington, Seattle., Van Voorhis WC; Department of Medicine, Division of Allergy and Infectious Disease, Center for Emerging and Reemerging Infectious Disease., Riggs MW; School of Animal and Comparative Biomedical Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson.

Publikováno v: The Journal of infectious diseases [J Infect Dis] 2016 Dec 15; Vol. 214 (12), pp. 1856-1864. Date of Electronic Publication: 2016 Oct 17.