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Osteogenic Differentiation of Human Adipose-Derived Stem Cells Seeded on a Biomimetic Spongiosa-like Scaffold: Bone Morphogenetic Protein-2 Delivery by Overexpressing Fascia.

Autor: Ren B; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians-University, Munich, Marchioninistr. 15, 81377 Munich, Germany.; Departments of Orthopedics, Zhongnan Hospital of Wuhan University, 430072 Wuhan, China., Betz OB; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians-University, Munich, Marchioninistr. 15, 81377 Munich, Germany.; Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA., Seitz D; BioMed Center Innovation gGmbH, 95448 Bayreuth, Germany., Thirion C; Sirion Biotech GmbH, Am Klopferspitz 19, 82152 Martinsried, Germany., Salomon M; Sirion Biotech GmbH, Am Klopferspitz 19, 82152 Martinsried, Germany., Jansson V; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians-University, Munich, Marchioninistr. 15, 81377 Munich, Germany., Müller PE; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians-University, Munich, Marchioninistr. 15, 81377 Munich, Germany., Betz VM; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians-University, Munich, Marchioninistr. 15, 81377 Munich, Germany.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Feb 28; Vol. 23 (5). Date of Electronic Publication: 2022 Feb 28.

Osteoinduction within BMP-2 transduced muscle tissue fragments with and without a fascia layer: implications for bone tissue engineering.

Autor: Ren B; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, Munich, Germany. Bin.Ren@yahoo.com., Betz VM; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, Munich, Germany., Thirion C; Sirion Biotech GmbH, Am Klopferspitz 19, 82152, Martinsried, Germany., Salomon M; Sirion Biotech GmbH, Am Klopferspitz 19, 82152, Martinsried, Germany., Jansson V; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, Munich, Germany., Müller PE; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, Munich, Germany., Betz OB; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377, Munich, Germany.

Publikováno v: Gene therapy [Gene Ther] 2019 Feb; Vol. 26 (1-2), pp. 16-28. Date of Electronic Publication: 2018 Oct 27.

Bone morphogenetic protein-2 is a stronger inducer of osteogenesis within muscle tissue than heterodimeric bone morphogenetic protein-2/6 and -2/7: Implications for expedited gene-enhanced bone repair.

Autor: Betz VM; Department of Gene Therapy, University of Ulm, Ulm, Germany.; Center for Rehabilitation, RKU - University and Rehabilitation Hospitals Ulm, Ulm, Germany., Ren B; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany., Messmer C; Center for Rehabilitation, RKU - University and Rehabilitation Hospitals Ulm, Ulm, Germany., Jansson V; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany., Betz OB; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Müller PE; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany.

Publikováno v: The journal of gene medicine [J Gene Med] 2018 Sep; Vol. 20 (9), pp. e3042. Date of Electronic Publication: 2018 Jul 24.

Gene-activated tissue grafts for sustained bone morphogenetic protein-2 delivery and bone engineering: Is muscle with fascia superior to muscle and fat?

Autor: Ren B; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany., Betz VM; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany., Thirion C; Sirion Biotech GmbH, Martinsried, Germany., Salomon M; Sirion Biotech GmbH, Martinsried, Germany., Jansson V; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany., Müller PE; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany., Betz OB; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany.

Publikováno v: Journal of tissue engineering and regenerative medicine [J Tissue Eng Regen Med] 2018 Apr; Vol. 12 (4), pp. 1002-1011. Date of Electronic Publication: 2017 Nov 22.