Osteogenic Differentiation of Human Adipose-Derived Stem Cells Seeded on a Biomimetic Spongiosa-like Scaffold: Bone Morphogenetic Protein-2 Delivery by Overexpressing Fascia.

Autor: Ren B; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians-University, Munich, Marchioninistr. 15, 81377 Munich, Germany.; Departments of Orthopedics, Zhongnan Hospital of Wuhan University, 430072 Wuhan, China., Betz OB; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians-University, Munich, Marchioninistr. 15, 81377 Munich, Germany.; Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA., Seitz D; BioMed Center Innovation gGmbH, 95448 Bayreuth, Germany., Thirion C; Sirion Biotech GmbH, Am Klopferspitz 19, 82152 Martinsried, Germany., Salomon M; Sirion Biotech GmbH, Am Klopferspitz 19, 82152 Martinsried, Germany., Jansson V; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians-University, Munich, Marchioninistr. 15, 81377 Munich, Germany., Müller PE; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians-University, Munich, Marchioninistr. 15, 81377 Munich, Germany., Betz VM; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians-University, Munich, Marchioninistr. 15, 81377 Munich, Germany.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Feb 28; Vol. 23 (5). Date of Electronic Publication: 2022 Feb 28.

Gene activated adipose tissue fragments as advanced autologous biomaterials for bone regeneration: osteogenic differentiation within the tissue and implications for clinical translation.

Autor: Ren B; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr 15, 81377, Munich, Germany. Bin.Ren@yahoo.com., Betz VM; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr 15, 81377, Munich, Germany., Thirion C; Sirion Biotech GmbH, Am Klopferspitz 19, 82152, Martinsried, Germany., Salomon M; Sirion Biotech GmbH, Am Klopferspitz 19, 82152, Martinsried, Germany., Klar RM; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr 15, 81377, Munich, Germany., Jansson V; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr 15, 81377, Munich, Germany., Müller PE; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr 15, 81377, Munich, Germany., Betz OB; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr 15, 81377, Munich, Germany.

Publikováno v: Scientific reports [Sci Rep] 2019 Jan 18; Vol. 9 (1), pp. 224. Date of Electronic Publication: 2019 Jan 18.

Recent advances in gene-enhanced bone tissue engineering.

Autor: Betz VM; Department of Gene Therapy, University of Ulm, Ulm, Germany.; Center for Rehabilitation, RKU - University and Rehabilitation Hospitals Ulm, Ulm, Germany., Kochanek S; Department of Gene Therapy, University of Ulm, Ulm, Germany., Rammelt S; University Center of Orthopedics and Traumatology and Center for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus Dresden, Technical University Dresden, Dresden, Germany., Müller PE; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany., Betz OB; Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany.; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Messmer C; Center for Rehabilitation, RKU - University and Rehabilitation Hospitals Ulm, Ulm, Germany.

Publikováno v: The journal of gene medicine [J Gene Med] 2018 Jun; Vol. 20 (6), pp. e3018. Date of Electronic Publication: 2018 May 09.

BMP-2 gene activated muscle tissue fragments for osteochondral defect regeneration in the rabbit knee.

Autor: Betz VM; University Center of Orthopaedics and Traumatology and Center for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus Dresden, Technical University Dresden, Dresden, Germany., Keller A; Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany., Foehr P; Department of Orthopaedics and Sportsorthopaedics, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Thirion C; Sirion Biotech GmbH, Martinsried, Germany., Salomon M; Sirion Biotech GmbH, Martinsried, Germany., Rammelt S; University Center of Orthopaedics and Traumatology and Center for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus Dresden, Technical University Dresden, Dresden, Germany.; DFG-Center for Regenerative Therapies Dresden, Dresden, Germany., Zwipp H; University Center of Orthopaedics and Traumatology and Center for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus Dresden, Technical University Dresden, Dresden, Germany.; DFG-Center for Regenerative Therapies Dresden, Dresden, Germany., Burgkart R; Department of Orthopaedics and Sportsorthopaedics, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Jansson V; Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany., Müller PE; Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany., Betz OB; Department of Orthopaedic Surgery, Physical Medicine and Rehabilitation, University Hospital Grosshadern, Ludwig-Maximilians-University Munich, Munich, Germany.

Publikováno v: The journal of gene medicine [J Gene Med] 2017 Sep; Vol. 19 (9-10). Date of Electronic Publication: 2017 Sep 22.

Osseous differentiation of human fat tissue grafts: From tissue engineering to tissue differentiation.

Autor: Bondarava M; University Hospital of Munich (LMU), Campus Grosshadern, Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, Munich, DE, Germany., Cattaneo C; University Hospital of Munich (LMU), Campus Grosshadern, Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, Munich, DE, Germany., Ren B; University Hospital of Munich (LMU), Campus Grosshadern, Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, Munich, DE, Germany., Thasler WE; University Hospital of Munich (LMU), Biobank under the administration of the Human Tissue and Cell Research (HTCR) Foundation, Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Munich, DE, Germany., Jansson V; University Hospital of Munich (LMU), Campus Grosshadern, Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, Munich, DE, Germany., Müller PE; University Hospital of Munich (LMU), Campus Grosshadern, Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, Munich, DE, Germany., Betz OB; University Hospital of Munich (LMU), Campus Grosshadern, Department of Orthopedic Surgery, Physical Medicine and Rehabilitation, Munich, DE, Germany.

Publikováno v: Scientific reports [Sci Rep] 2017 Jan 05; Vol. 7, pp. 39712. Date of Electronic Publication: 2017 Jan 05.