Zobrazeno 1 - 10
of 174
pro vyhledávání: '"Betty Yuen‐Kwan Law"'
Autor:
Xiaogang Zhou, Jing Wang, Lu Yu, Gan Qiao, Dalian Qin, Betty Yuen-Kwan Law, Fang Ren, Jianming Wu, Anguo Wu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 8, Pp 3327-3361 (2024)
Mitophagy, essential for mitochondrial health, selectively degrades damaged mitochondria. It is intricately linked to the cGAS–STING pathway, which is crucial for innate immunity. This pathway responds to mitochondrial DNA and is associated with ce
Externí odkaz:
https://doaj.org/article/1471e72ae72c4e8f9f45471e7ca494cb
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-20 (2024)
Abstract Diabetic cardiomyopathy (DCM) is a major contributor to mortality in diabetic patients, characterized by a multifaceted pathogenesis and limited therapeutic options. While lactate, a byproduct of glycolysis, is known to be significantly elev
Externí odkaz:
https://doaj.org/article/4eacbb6a4f924cb48db92829cff15900
Autor:
Yong Tang, Jing Wei, Xiao-Fang Wang, Tao Long, Xiaohong Xiang, Liqun Qu, Xingxia Wang, Chonglin Yu, Xingli Xiao, Xueyuan Hu, Jing Zeng, Qin Xu, Anguo Wu, Jianming Wu, Dalian Qin, Xiaogang Zhou, Betty Yuen-Kwan Law
Publikováno v:
Neural Regeneration Research, Vol 19, Iss 11, Pp 2467-2479 (2024)
Amyloid-beta-induced neuronal cell death contributes to cognitive decline in Alzheimer’s disease. Citri Reticulatae Semen has diverse beneficial effects on neurodegenerative diseases, including Parkinson’s and Huntington’s diseases, however, th
Externí odkaz:
https://doaj.org/article/47fd4ae8f9814548af6e3edf2a0cae7a
Autor:
Wen‐Qiao Qiu, Lu Yu, Chang‐Long He, Jian‐Ming Wu, Betty Yuen‐Kwan Law, Chong‐Lin Yu, Da‐Lian Qin, Xiao‐Gang Zhou, An‐Guo Wu
Publikováno v:
Clinical and Translational Medicine, Vol 13, Iss 9, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/366e1b0efe8b4eac82aaf8957c4baab7
Autor:
Xiao-Gang Zhou, Wen-Qiao Qiu, Lu Yu, Rong Pan, Jin-Feng Teng, Zhi-Pei Sang, Betty Yuen-Kwan Law, Ya Zhao, Li Zhang, Lu Yan, Yong Tang, Xiao-Lei Sun, Vincent Kam Wai Wong, Chong-Lin Yu, Jian-Ming Wu, Da-Lian Qin, An-Guo Wu
Publikováno v:
Inflammation and Regeneration, Vol 42, Iss 1, Pp 1-25 (2022)
Abstract Background NLRP3 inflammasome-mediated neuroinflammation plays a critical role in the pathogenesis and development of Alzheimer’s disease (AD). Microglial autophagic degradation not only decreases the deposits of extracellular Aβ fibrils
Externí odkaz:
https://doaj.org/article/18737a8c81c4472581e4f0c99e7cbaf2
Autor:
Minsong Guo, Fengdan Zhu, Wenqiao Qiu, Gan Qiao, Betty Yuen-Kwan Law, Lu Yu, Jianming Wu, Yong Tang, Chonglin Yu, Dalian Qin, Xiaogang Zhou, Anguo Wu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 4, Pp 1723-1739 (2022)
Discovery of drugs rapidly and effectively is an important aspect for Alzheimer's disease (AD). In this study, a novel high-throughput screening (HTS) method aims at screening the small-molecules with amyloid-β (Aβ) binding affinity from natural me
Externí odkaz:
https://doaj.org/article/be053c1fb28047ccb0c66f356830e655
Autor:
Li Peng, Guangqiang Hu, Qianfang Yao, Jianming Wu, Ziyang He, Betty Yuen-Kwan Law, Guishan Hu, Xiaogang Zhou, Junrong Du, Anguo Wu, Lu Yu
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Ischemic stroke (IS) is one of the major types of cerebrovascular diseases causing neurological morbidity and mortality worldwide. In the pathophysiological process of IS, microglia play a beneficial role in tissue repair. However, it could also caus
Externí odkaz:
https://doaj.org/article/e30b69b89c1a438397eff1a4546e5177
Autor:
An-Guo Wu, Rong Pan, Betty Yuen-Kwan Law, Wen-Qiao Qiu, Jian-Ming Wu, Chang-Long He, Vincent Kam-Wai Wong, Chong-Lin Yu, Xiao-Gang Zhou, Da-Lian Qin
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/2cc1c54c6dea4a93936eab01c40a4a9b
Autor:
Hualin Sun, Junjie Sun, Ming Li, Lei Qian, Lilei Zhang, Ziwei Huang, Yuntian Shen, Betty Yuen-Kwan Law, Liang Liu, Xiaosong Gu
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundInflammation may trigger skeletal muscle atrophy induced by cancer cachexia. As a pro-inflammatory factor, interleukin-6 may cause skeletal muscle atrophy, but the underlying molecular mechanisms have not been explored.MethodsIn this experi
Externí odkaz:
https://doaj.org/article/5bbfe0e7a6074b7eba62dddc7dbc4df3
Autor:
Lu Yu, An-Guo Wu, Vincent Kam-Wai Wong, Li-Qun Qu, Ni Zhang, Da-Lian Qin, Wu Zeng, Bin Tang, Hui-Miao Wang, Qiong Wang, Betty Yuen-Kwan Law
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Literary evidence depicts that aggregated β-amyloid (Aβ) leads to the pathogenesis of Alzheimer’s disease (AD). Although many traditional Chinese medicines (TCMs) are effective in treating neurodegenerative diseases, there is no effective way for
Externí odkaz:
https://doaj.org/article/06d8b361274d4b22807b138867d9256d