Merestinib (LY2801653) inhibits neurotrophic receptor kinase (NTRK) and suppresses growth of NTRK fusion bearing tumors.

Autor: Konicek BW; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Capen AR; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Credille KM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Ebert PJ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Falcon BL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Heady GL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Patel BKR; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Peek VL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Stephens JR; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Stewart JA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Stout SL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Timm DE; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Um SL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Willard MD; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Wulur IH; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Zeng Y; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Wang Y; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Walgren RA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA., Betty Yan SC; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.

Publikováno v: Oncotarget [Oncotarget] 2018 Feb 13; Vol. 9 (17), pp. 13796-13806. Date of Electronic Publication: 2018 Feb 13 (Print Publication: 2018).