Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Betty Peng"'
Autor:
Mei Yu, Betty Peng, Simin Xu, Nikos Pagratis, Ruoyu Gong, William E. Delaney, Guofeng Cheng, Hadas Dvory-Sobol, Brian P. Doehle, Yang Tian, Bin Han, John O. Link, Yu-Jen Lee, Amoreena C. Corsa, Yili Xu, Hongmei Mo, Michel Perron
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:1847-1853
Ledipasvir (LDV; GS-5885), a component of Harvoni (a fixed-dose combination of LDV with sofosbuvir [SOF]), is approved to treat chronic hepatitis C virus (HCV) infection. Here, we report key preclinical antiviral properties of LDV, including in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48fd0106c336f484a251b3aa4b1a765
https://doi.org/10.1128/aac.02524-15
https://doi.org/10.1128/aac.02524-15
Genotype 6 (GT6) hepatitis C virus (HCV) is prevalent in Southeast Asia and southern China, where it can constitute up to 50% of HCV infections. Despite this, no direct-acting antivirals are approved to treat GT6 HCV infection, and no cell culture sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02cc914792cd3bc2897e8fdae180563b
https://europepmc.org/articles/PMC3993266/
https://europepmc.org/articles/PMC3993266/
Autor:
Betty Peng, Yang Tian, Choung U. Kim, Joy Y. Feng, Aesop Cho, Martijn Fenaux, Michel Perron, Debi Jin, Adrian S. Ray, Mei Yu, Kathryn M. Kitrinos, Stacey Eng, Kelly A. Wong, Magdeleine Hung, Karin S. Ku, Gabriel Birkus, Guofeng Cheng, Weidong Zhong, Leanna Lagpacan, Bin Han, Yili Xu, Ona Barauskas, George Stepan, Anne Carey, Jason K. Perry, Neeraj Tirunagari, Yu-Jen Lee
Publikováno v:
Antimicrobial agents and chemotherapy. 58(4)
As a class, nucleotide inhibitors (NIs) of the hepatitis C virus (HCV) nonstructural protein 5B (NS5B) RNA-dependent RNA polymerase offer advantages over other direct-acting antivirals, including properties, such as pangenotype activity, a high barri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45360a8980bed1810ea06708172a3ab
https://pubmed.ncbi.nlm.nih.gov/24419349
https://pubmed.ncbi.nlm.nih.gov/24419349
Autor:
Steve H. Krawczyk, Marian Shen, Rowchanak Pakdaman, Choung U. Kim, William E. Delaney, Xiaoping Qi, Chin Tay, Hongmei Mo, Yang Tian, Huiling Yang, X. Christopher Sheng, Guofeng Cheng, Amoreena C. Corsa, Yujin Wang, Betty Peng, Margaret Robinson, Chris Yang
Publikováno v:
Antimicrobial agents and chemotherapy. 58(2)
GS-9451 is a selective hepatitis C virus (HCV) NS3 protease inhibitor in development for the treatment of genotype 1 (GT1) HCV infection. Key preclinical properties of GS-9451, including in vitro antiviral activity, selectivity, cross-resistance, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b208ecc462d0045cd0a382b2218120
https://pubmed.ncbi.nlm.nih.gov/23939899
https://pubmed.ncbi.nlm.nih.gov/23939899
Autor:
William E. Delaney, Katie Chan, Yu-Jen Lee, Simin Xu, Mei Yu, Betty Peng, Guofeng Cheng, Hongmei Mo, Amoreena C. Corsa, Ruoyu Gong
Publikováno v:
Antiviral research. 100(2)
Infection with genotype 3 hepatitis C virus (HCV) is common throughout the world, however no direct-acting antiviral (DAA) has been approved to treat this genotype. We therefore attempted to develop novel genotype 3 replicons to facilitate the discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e15f5492254abd11e6701843a4deda6
https://pubmed.ncbi.nlm.nih.gov/24013001
https://pubmed.ncbi.nlm.nih.gov/24013001
Autor:
Yang Tian, Betty Peng, Weidong Zhong, Matthew Paulson, William A. Lee, Gerhard Pürstinger, Uli Schmitz, I-hung Shih, Johan Neyts, Xiaoping Qi, Tse Winston C, Steven S. Bondy, Huiling Yang, Eric Mabery, Hans Reiser, Laura S. Lehman, Jan Paeshuyse, Inge Vliegen, Martijn Fenaux, Christy M. Hebner, Gina Bahador
Publikováno v:
Antimicrobial agents and chemotherapy. 55(9)
GS-9190 (Tegobuvir) is a novel imidazopyridine inhibitor of hepatitis C virus (HCV) RNA replication in vitro and has demonstrated potent antiviral activity in patients chronically infected with genotype 1 (GT1) HCV. GS-9190 exhibits reduced activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0c95c10a4eca67ef085c251f5527d5
https://pubmed.ncbi.nlm.nih.gov/21746939
https://pubmed.ncbi.nlm.nih.gov/21746939
Autor:
Siu-Chi Sun, Yang Tian, Huiling Yang, Betty Peng, Nikos Pagratis, Margaret Robinson, William E. Delaney, Andrew E. Greenstein
The hepatitis C virus (HCV) subgenomic replicon is the primary tool for evaluating the activity of anti-HCV compounds in drug discovery research. Despite the prevalence of HCV genotype 1a (∼70% of U.S. HCV patients), few genotype 1a reporter replic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a315e1ae4c094c24694b165130687220
https://europepmc.org/articles/PMC2916306/
https://europepmc.org/articles/PMC2916306/
Autor:
William E. Delaney, Katie Chan, Huiling Yang, Mei Yu, Yu-Jen Lee, Guofeng Cheng, Betty Peng, Yang Tian, Simin Xu, John G. McHutchison, Hongmei Mo
Publikováno v:
Gastroenterology. 144:59-61.e6
Despite the prevalence of hepatitis C virus genotype 4, no replicon system is available for study of the genotype. To facilitate discovery and development of reagents against this virus, we synthesized and transcribed a genotype 4a subgenomic replico
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::776b021a1198596d8960df1c4bf027bd
https://doi.org/10.1053/j.gastro.2012.09.033
https://doi.org/10.1053/j.gastro.2012.09.033
Autor:
Yang Tian, Yu-Jen Lee, Guofeng Cheng, J. McHutchison, Betty Peng, Hongmei Mo, N. Pagratis, Simin Xu, Mei Yu, Bin Han, K. Chan, William E. Delaney
Publikováno v:
Journal of Hepatology. 56:S322
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c179d94ca2ace508baf4495712d88a3a
https://doi.org/10.1016/s0168-8278(12)60837-x
https://doi.org/10.1016/s0168-8278(12)60837-x