Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Betty P.K. Poon"'
Autor:
Stephenie Naugler, Shannon E. McCaw, Furkan Guvenc, Ayoob Ghalami, Steven Hayes, Rachel Tyli, Betty P.K. Poon, Natasha Christie-Holmes, Rita A. Kandel, Amit Weiner, Mary Speck, Ori D. Rotstein, Scott D. Gray-Owen, James A. Scott, Allen Rainville, Patrick Budylowski, Samira Mubareka
Publikováno v:
American Journal of Infection Control
Background The COVID-19 pandemic highlighted the need for evidence-based approaches to decontamination and reuse of N95 filtering facepiece respirators (FFRs). We sought to determine whether vapourized hydrogen peroxide (VHP) reduced SARS-CoV-2 biobu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a599e91e6055db72c85a69f35d0422
https://doi.org/10.1016/j.ajic.2021.07.012
https://doi.org/10.1016/j.ajic.2021.07.012
Autor:
Antoine Corbeil, Laura Finlay, Trevor Lau, Caylin Frankland, Christopher Kandel, Elena Sheldrake, Robert A. Kozak, Betty P.K. Poon, Laura E. Burnes, Jonathan B. Gubbay, Shawn T. Clark, Kevin Katz, Natasha Christie-Holmes, Amna Faheem, Michael Phan
Publikováno v:
Journal of Clinical Virology
Background Point-of-care tests (POCT) are promising tools to detect SARS-CoV-2 in specific settings. Initial reports suggest the ID NOW™ COVID-19 assay (Abbott Diagnostics Inc, USA) is less sensitive than standard real-time reverse transcription po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a1e2d3946c6eb3a9501cd7bcb6632b
https://pubmed.ncbi.nlm.nih.gov/34174710
https://pubmed.ncbi.nlm.nih.gov/34174710
Autor:
Jonathan St-Germain, Molly L. Udaskin, Betty P.K. Poon, Ahmet Mentes, Wenguang He, Nikolina Radulovich, Jinmin Miao, Claire M. Robinson, Christopher B. Marshall, Melissa Huestis, Zhong Yin Zhang, Richard Huang, Michael Ohh, Teklab Gebregiworgis, Ming-Sound Tsao, Jeffrey E. Lee, Ivette Valencia-Sama, Mitsuhiko Ikura, Meredith S. Irwin, Jen Jen Yeh, Yoshihito Kano, Brian Raught
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Cancer cells bearing distinct KRAS mutations exhibit variable sensitivity to SHP2 inhibitors (SHP2i). Here we show that cells harboring KRAS Q61H are uniquely resistant to SHP2i, and investigate the underlying mechanisms using biophysics, molecular d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771f797a1c77d0c2cdf65c849c908dfd
https://pubmed.ncbi.nlm.nih.gov/34725361
https://pubmed.ncbi.nlm.nih.gov/34725361
Autor:
Claire M. Robinson, Michael Ohh, Walter H. A. Kahr, Yoshihito Kano, Fred G. Pluthero, Betty P.K. Poon
Publikováno v:
Molecular cancer research : MCR. 17(11)
Clear cell renal cell carcinoma (ccRCC) is the most common form of kidney cancer and the major cause of mortality for individuals with von Hippel-Lindau (VHL) disease. ccRCC is characterized most frequently by inactivation of VHL tumor suppressor pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184f8618c284def926ee745711769a4d
https://pubmed.ncbi.nlm.nih.gov/33811174
https://pubmed.ncbi.nlm.nih.gov/33811174
Autor:
Teklab Gebregiworgis, Jonathan D. Cook, Ivette Valencia-Sama, Christopher B. Marshall, Mitsuhiko Ikura, Brian Raught, Nikolina Radulovich, Michael Ohh, Jen Jen Yeh, Zhong Yin Zhang, Yoshihito Kano, Silvia Gabriela Herrera, Ming-Sound Tsao, Meredith S. Irwin, Jinmin Miao, Betty P.K. Poon, Jeffrey E. Lee, Jonathan St-Germain, Benjamin M M Grant
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Deregulation of the RAS GTPase cycle due to mutations in the three RAS genes is commonly associated with cancer development. Protein tyrosine phosphatase SHP2 promotes RAF-to-MAPK signaling pathway and is an essential factor in RAS-driven oncogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc59b457913d9c6e576847f75c6aea16
http://europepmc.org/articles/PMC6333830
http://europepmc.org/articles/PMC6333830
Autor:
Yasser Riazalhosseini, Michael Ohh, Xiaojun Fan, Claire M. Robinson, William Y. Kim, François Lefebvre, Aurelie Bousard, Jörg Tost, Mark Lathrop, Betty P.K. Poon
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
Scientific Reports
In clear-cell renal cell carcinoma (ccRCC), loss of von Hippel-Lindau (VHL) tumour suppressor gene and reduced oxygen tension promote stabilisation of hypoxia-inducible factor (HIF) family of transcription factors, which promote changes in the expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da91294cde9435c927921af4d0eb5dd6
https://doi.org/10.1038/s41598-018-21524-5
https://doi.org/10.1038/s41598-018-21524-5
Autor:
Betty P.K. Poon, Tony Liu, Andrew Emili, Jonathan B. Olsen, Jayesh S. Salvi, Nurussaba Khanam, Janet N.Y. Chan, Kirk Szafranski, Jane D. Wu, Karim Mekhail
Publikováno v:
Developmental Cell. 30(2):177-191
Summary Intergenic transcription within repetitive loci such as the ribosomal DNA (rDNA) repeats of yeast commonly triggers aberrant recombination. Major mechanisms suppressing aberrant rDNA recombination rely on chromatin silencing or RNAPII repress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89278f7860b104346ce444caaa02fbdd
Autor:
Samantha N Greer, Betty P.K. Poon, Jeffrey E. Lee, Michael Ohh, Roxana I. Sufan, Pardeep Heir
Publikováno v:
Molecular and Cellular Biology. 33:1621-1631
Substrate engagement by F-box proteins promotes NEDD8 modification of cullins, which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). However, the mechanism by which substrate recruitment triggers cullin neddylation remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df751434b6874444327e9c4b0a2eee3b
https://doi.org/10.1128/mcb.01342-12
https://doi.org/10.1128/mcb.01342-12
Autor:
Severa Bunda, Jeffrey E. Lee, Brian Raught, Pardeep Heir, Betty P.K. Poon, Tharan Srikumar, George Bikopoulos, Michael Ohh
von Hippel-Lindau (VHL) disease is a rare familial cancer predisposition syndrome caused by a loss or mutation in a single gene, VHL, but it exhibits a wide phenotypic variability that can be categorized into distinct subtypes. The phenotypic variabi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4962430a7d3227e71d80cb12d47b1430
https://europepmc.org/articles/PMC4817168/
https://europepmc.org/articles/PMC4817168/
Autor:
Mitsuhiko Ikura, Betty P.K. Poon, Nikolina Radulovich, Teklab Gebregiworgis, Ming-Sound Tsao, Yoshihito Kano, Christopher B. Marshall, Michael Ohh, Zhong Yin Zhang
Publikováno v:
Gastroenterology. 154:S-173
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec105bb3553e9d6ce75cc3b3aafa9a2e
https://doi.org/10.1016/s0016-5085(18)30991-0
https://doi.org/10.1016/s0016-5085(18)30991-0