Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Betty Lam"'
Autor:
Dimitrios Varrias, Nikhil Sharma, Roland Hentz, Rosaline Ma, Dillon Gurciullo, Jeremy Kleiman, Andrew Kossack, Eliot Wolf, Betty Lam, Tia Bimal, Umair Ansari, Kristie M. Coleman, Stavros E. Mountantonakis
Publikováno v:
BMC Pregnancy and Childbirth, Vol 22, Iss 1, Pp 1-7 (2022)
Abstract Background Persistent sinus tachycardia (ST) is frequently encountered during pregnancy and peripartum period and its etiology often remains elusive. We sought to examine the possible association between unexplained persistent ST and obstetr
Externí odkaz:
https://doaj.org/article/b6470dbd913847cb9e9cf41cd083bd2e
Autor:
Donavon McConn, Betty Lam, Victoria J Mulligan, Nicola Brice, Hans H Schiffer, Holger Monenschein, Stephen Hitchcock, Holly Reichard, Nidhi Kaushal, Deanna R Collia, Philip L R Gaskin, Jordi Serrats, Alejandro Amador-Arjona, William J. Ray, Jackie Cilia, Joshua Bliesath, Alton W Skaggs, Josephine Atienza, Gerard Corbett, Lisa Rahbaek
Publikováno v:
Journal of Medicinal Chemistry. 64:11527-11542
The orphan G-protein-coupled receptor GPR139 is highly expressed in the habenula, a small brain nucleus that has been linked to depression, schizophrenia (SCZ), and substance-use disorder. High-throughput screening and a medicinal chemistry structure
Publikováno v:
Contemporary clinical trials. 121
Electronic medical records are increasingly being leveraged to improve the efficiency and effectiveness of clinical trials. Reporting safety data and adhering to follow-up schedules are two challenges faced by study centers conducting a large number
Autor:
Prithviraj Bose, Sanjay Mohan, Stephen Oh, Jason Gotlib, Ellen Ritchie, Taizo Shimomura, Haris Ali, Francoise Boyer, Paola Guglielmelli, Anthony M. Hunter, Betty Lamothe, Yi Cui, Francis Seguy, Amanda Mcbride, Francesca Palandri, Masahiro Takeuchi, Jean-Jacques Kiladjian
Publikováno v:
HemaSphere, Vol 7, p e41693dd (2023)
Externí odkaz:
https://doaj.org/article/b96b25916b174c2e9c3fa889b4d0c091
Autor:
Shin-ichi Matsumoto, Jeffrey A. Stafford, Betty Lam, Zhe Nie, Noriko Uchiyama, Yan Liu, Lilly Zhang, Koki Hikami, Feher Victoria, Kiryanov Andre A, Nobuyuki Amano, David J. Hosfield, Srinivasa Reddy Natala, Robert J. Skene, Xiaodong Cao, Hua Zou, Christopher McBride, Yuichi Hikichi, Tomohiro Kawamoto, Stephen W. Kaldor, Takashi Ichikawa, Jones Benjamin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3662-3666
Using structure-based drug design, we identified and optimized a novel series of pyrimidodiazepinone PLK1 inhibitors resulting in the selection of the development candidate TAK-960. TAK-960 is currently undergoing Phase I evaluation in adult patients
Autor:
Robert J. Skene, Stephen L. Gwaltney, Betty Lam, Lihong Shi, Jeffery A. Stafford, Zhiyuan Zhang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6628-6631
Dipeptidyl peptidase IV (DPP-4) inhibitors have been shown to enhance GLP-1 levels and thereby improve hyperglycemia in type II diabetes. From a small fragment hit, using structure-based design, we have discovered a new class of non-covalent, potent
Autor:
Yasuyoshi Arikawa, Pamela Farrell, Betty Lam, Lihong Shi, Zhe Nie, Jones Benjamin, Jonathan Zalevsky, Takahashi Masashi, Victoria A. Feher, Isaac Hoffman, Joshua Cramlett, Corey Wyrick, Hiroshi Miyake, Jennifer Matuszkiewicz, Joanne Miura, Ron de Jong, Charles E. Grimshaw, Jason Yano, Qing Dong, Srinivasa Reddy Natala, Ewan Taylor, Andrew John Jennings
Publikováno v:
Bioorganicmedicinal chemistry letters. 26(24)
Spleen Tyrosine Kinase (SYK) is a non-receptor cytoplasmic tyrosine kinase that is primarily expressed in hematopoietic cells. SYK is a key mediator for a variety of inflammatory cells, including B cells, mast cells, macrophages and neutrophils and t
Autor:
Kouhei Honda, Betty Lam, Xiaodong Cao, Tomohiro Kawamoto, David J. Hosfield, Takashi Ichikawa, Hua Zou, Srinivasa Reddy Natala, Kiryanov Andre A, Jones Benjamin, Yuichi Hikichi, Robert J. Skene, Jeffrey A. Stafford, Feher Victoria, Christopher McBride, Noriko Uchiyama, Yan Liu, Lilly Zhang
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(5)
Using structure-based drug design, we identified a novel series of 5,6-dihydroimidazolo[1,5-f]pteridine PLK1 inhibitors. Rational improvements to compounds of this class resulted in single-digit nanomolar enzyme and cellular activity against PLK1, an
Autor:
Seshasai, Sudarshan, He, Feng, Wen, Betty Lam Jia, Hamzah, Haslina, Cheng, Ching-Yu, Li, Jialiang, Wong, Tien Yin, Tan, Gavin Siew Wei, Sabanayagam, Charumathi
Publikováno v:
Asia-Pacific Journal of Ophthalmology; 20240101, Issue: Preprints
Autor:
Betty Lamothe, Yunju Lai, Lana Hur, Natalia Martin Orozco, Jing Wang, Alejandro D Campos, Min Xie, Michael D Schneider, Cynthia R Lockworth, Jared Jakacky, Diep Tran, Michael Ho, Sity Dawud, Chen Dong, Hui-Kuan Lin, Peter Hu, Zeev Estrov, Carlos E Bueso-Ramos, Bryant G Darnay
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51228 (2012)
Previous studies of the conditional ablation of TGF-β activated kinase 1 (TAK1) in mice indicate that TAK1 has an obligatory role in the survival and/or development of hematopoietic stem cells, B cells, T cells, hepatocytes, intestinal epithelial ce
Externí odkaz:
https://doaj.org/article/f98ab889e1f742eb83b60ac8a1485b44