Zobrazeno 1 - 10 of 14 pro vyhledávání: '"Betty Hoac"'
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Akademický článek
The role of extracellular matrix phosphorylation on energy dissipation in bone
Autor: Stacyann Bailey, Grazyna E Sroga, Betty Hoac, Orestis L Katsamenis, Zehai Wang, Nikolaos Bouropoulos, Marc D McKee, Esben S Sørensen, Philipp J Thurner, Deepak Vashishth
Publikováno v: eLife, Vol 9 (2020)
Protein phosphorylation, critical for cellular regulatory mechanisms, is implicated in various diseases. However, it remains unknown whether heterogeneity in phosphorylation of key structural proteins alters tissue integrity and organ function. Here,
Externí odkaz: https://doaj.org/article/93fc932c9bd84bb49dd5fb7d47765f13
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2
The role of extracellular matrix phosphorylation on energy dissipation in bone
Autor: Orestis L. Katsamenis, Deepak Vashishth, Betty Hoac, Philipp J. Thurner, Zehai Wang, Esben S. Sørensen, Grażyna E. Sroga, Nikolaos Bouropoulos, Stacyann Bailey, Marc D. McKee
Publikováno v: Bailey, S, Sroga, G E, Hoac, B, Katsamenis, O L, Wang, Z, Bouropoulos, N, McKee, M D, Sørensen, E S, Thurner, P J & Vashishth, D 2020, ' The role of extracellular matrix phosphorylation on energy dissipation in bone ', eLife, vol. 9, e58184 . https://doi.org/10.7554/eLife.58184
eLife
eLife, Vol 9 (2020)
Protein phosphorylation, critical for cellular regulatory mechanisms, is implicated in various diseases. However, it remains unknown whether heterogeneity in phosphorylation of key structural proteins alters tissue integrity and organ function. Here,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2bef1be8341d9a645efdfd3f7b254e9
https://pure.au.dk/portal/da/publications/the-role-of-extracellular-matrix-phosphorylation-on-energy-dissipation-in-bone(cbf765d8-63df-4eb0-afdc-46554c9c9515).html
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4
Genetic Ablation of Osteopontin in Osteomalacic Hyp Mice Partially Rescues the Deficient Mineralization Without Correcting Hypophosphatemia
Autor: Henrik Birkedal, Monzur Murshed, Betty Hoac, Marc D. McKee, Nina Kølln Wittig, Daniel J. Buss, Tchilalo Boukpessi, Catherine Chaussain, Maja Østergaard
Publikováno v: Hoac, B, Østergaard, M, Wittig, N K, Boukpessi, T, Buss, D J, Chaussain, C, Birkedal, H, Murshed, M & McKee, M D 2020, ' Genetic Ablation of Osteopontin in Osteomalacic Hyp Mice Partially Rescues the Deficient Mineralization Without Correcting Hypophosphatemia ', Journal of Bone and Mineral Research, vol. 35, no. 10, pp. 2032-2048 . https://doi.org/10.1002/jbmr.4101
PHEX is predominantly expressed by bone and tooth-forming cells, and its inactivating mutations in X-linked hypophosphatemia (XLH) lead to renal phosphate wasting and severe hypomineralization of bones and teeth. Also present in XLH are hallmark hypo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a345352f027ae0fd7f33e5bd83abdf3
https://pubmed.ncbi.nlm.nih.gov/32501585
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5
Osteopontin as a novel substrate for the proprotein convertase 5/6 (PCSK5) in bone
Autor: Rachid Essalmani, Edwige Marcinkiweicz, Betty Hoac, Marc D. McKee, Nabil G. Seidah, Delia Susan-Resiga
Publikováno v: Bone. 107:45-55
Seven proprotein convertases cleave the basic amino acid consensus sequence K/R-Xn-K/R↓ (where n=0, 2, 4 or 6 variable amino acids) to activate precursor proteins. Despite similarities in substrate specificity, basic amino acid-specific proprotein
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f1106d2bd6b9997d46a6de41eb74225
https://doi.org/10.1016/j.bone.2017.11.002
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Mineralization-inhibiting effects of transglutaminase-crosslinked polymeric osteopontin
Autor: Mari T. Kaartinen, Betty Hoac, Marc D. McKee, Valentin Nelea, Wenge Jiang
Publikováno v: Bone. 101:37-48
Osteopontin (OPN) belongs to the SIBLING family (Small, Integrin-Binding LIgand N-linked Glycoproteins) of mineral-binding matrix proteins found in bones and teeth. OPN is a well-known inhibitor of matrix mineralization, and enzymatic modification of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd3feb7499c00fb73da8be92c015d278
https://doi.org/10.1016/j.bone.2017.04.007
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7
Biological stenciling of mineralization in the skeleton: Local enzymatic removal of inhibitors in the extracellular matrix
Autor: Betty Hoac, Marc D. McKee, Nilana M.T. Barros, Daniel J. Buss, William N. Addison, Natalie Reznikov
Publikováno v: Bone. 138:115447
Biomineralization is remarkably diverse and provides myriad functions across many organismal systems. Biomineralization processes typically produce hardened, hierarchically organized structures usually having nanostructured mineral assemblies that ar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d554f5bbc02b7e3b116c0363aebc32
https://doi.org/10.1016/j.bone.2020.115447
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8
Defective Mineralization in X-Linked Hypophosphatemia Dental Pulp Cell Cultures
Autor: Lotfi Slimani, P. Chafey, Benjamin R. Coyac, Peter S. N. Rowe, Agnès Linglart, Guillaume Falgayrac, Guillaume Penel, Marc D. McKee, Claire Bardet, Betty Hoac, Catherine Chaussain
Publikováno v: Journal of dental research. 97(2)
X-linked hypophosphatemia (XLH) is a skeletal disease caused by inactivating mutations in the PHEX gene. Mutated or absent PHEX protein/enzyme leads to a decreased serum phosphate level, which cause mineralization defects in the skeleton and teeth (o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9306ac9b65f26fc20c06341a5231971
https://pubmed.ncbi.nlm.nih.gov/28880715
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9
Osteopontin and the dento-osseous pathobiology of X-linked hypophosphatemia
Autor: Camille Garcia, Thibaut Léger, Agnès Linglart, Tchilalo Boukpessi, Betty Hoac, Francis H. Glorieux, Benjamin R. Coyac, Michael P. Whyte, Catherine Chaussain, Marc D. McKee, Philippe Wicart
Publikováno v: BONE
BONE, Elsevier, 2017, 95, pp.151-161. 〈10.1016/j.bone.2016.11.019〉
BONE, Elsevier, 2017, 95, pp.151-161. ⟨10.1016/j.bone.2016.11.019⟩
Seven young patients with X-linked hypophosphatemia (XLH, having inactivating PHEX mutations) were discovered to accumulate osteopontin (OPN) at the sites of defective bone mineralization near osteocytes − the so-called hallmark periosteocytic (lac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c29d8e7141f8efb6d43157b4ee6391c
https://hal.archives-ouvertes.fr/hal-01616767
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10
Mineralization of Dense Collagen Hydrogel Scaffolds by Human Pulp Cells
Autor: Showan N. Nazhat, Florencia Chicatun, Marc D. McKee, Catherine Chaussain, Valentin Nelea, Betty Hoac, Benjamin R. Coyac
Publikováno v: Journal of Dental Research. 92:648-654
While advances in biomineralization have been made in recent years, unanswered questions persist on bone- and tooth-cell differentiation, on outside-in signaling from the extracellular matrix, and on the link between protein expression and mineral de
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3581f5e5758fc4857b4bc94450afdbb2
https://doi.org/10.1177/0022034513488599
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