Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Betty Badger"'
Publikováno v:
Cancer Letters. 66:1-9
Recent in vitro data suggest that at least some hormone-independent breast cancer cells exhibit increased polyamine biosynthesis and resistance to antipolyamine therapy. To address this issue under conditions of in vivo growth, we tested the antiprol
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 38:687-693
The biological role of transforming growth factor-alpha (TGF-alpha) in basal and hormone-stimulated proliferation of primary human and rat mammary tumor cells was studied using antibodies against TGF-alpha and its receptor. A monoclonal antibody, MAb
Publikováno v:
Breast Cancer Research and Treatment. 17:187-196
The present experiments were designed to evaluate the polyamine involvement in hormonal actions on proliferation and receptor content of neoplastic tissue (hormone-responsive breast cancer) as well as on growth of normal endocrine target tissue (uter
Autor:
J. Leighton, Andrea Manni, N. Ling, Andrea L. Zaenglein, Betty Badger, Lisa Wei, Shunichi Shimasaki
Publikováno v:
Endocrinology. 130:1744-1746
We report the expression of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) by breast cancer cells and normal breast tissue in vivo. N-nitrosomethyl-urea (NMU)-induced rat mammary tumors synthesize mRNAs for IGF-II and IGFBP-2,
Publikováno v:
Cancer letters. 95(1-2)
We report the first successful isolation and initial characterization of S-adenosylmethionine decarboxylase (SAMDC)-overexpressing cells using a transfection approach. Stably transfected MCF-7 breast cancer overproducing SAMDC (approximately 5-fold)
Autor:
Anthony Rossini, Rita Wechter, Laurence M. Demers, Betty Badger, Andrea Manni, Susan J. Kunselman
Publikováno v:
International journal of cancer. 62(4)
CGP 48664 [4-aminoindanon-1-(2′-amidino)hydrazone dihydrochloride monohydrate] is a newly introduced inhibitor of S-adenosyltnethionine decarboxylase (SAMDC) with increased selectivity of action and reduced toxichy. We analyzed the biochemical and
Autor:
Andrea Manni, Carol Wright, John Mendelsohn, Betty Badger, Mary Bartholomew, Hideo Masui, Laurence M. Demers, Meenhard Herlyn
Publikováno v:
Breast cancer research and treatment. 15(2)
We have recently suggested that estradiol (E2), prolactin (oPrl), and progesterone (Pg) support the growth of the hormone-responsive N-nitrosomethylurea (NMU) rat mammary tumor in soft agar through autocrine/paracrine mechanisms. To gain insight into
Publikováno v:
Breast cancer research and treatment. 14(2)
The present experiments were designed to test whether, in the hormone responsive N-nitrosomethyl-urea (NMU)-induced rat mammary tumor, polyamine levels are under hormonal control and whether they correlate with estrogen (ER) and progesterone (PgR) re
Publikováno v:
European journal of cancerclinical oncology. 24(8)
Recent evidence indicates that autocrine/paracrine mechanisms may mediate the mitogenic effect of estradiol (E 2 ) both in human and experimental breast cancer. However, the species-specificity of E 2 -regulated growth factors with regard to their bi
Publikováno v:
Breast cancer research and treatment. 10(2)
The present experiments were designed to test whether polyamines play an essential role in the synthesis of growth factors induced by ovine prolactin (oPRL), using the N-nitrosomethylurea (NMU)-induced rat mammary tumor cultured in the soft agar clon