Serum Voriconazole Level Variability in Patients with Hematological Malignancies Receiving Voriconazole Therapy

Autor: Lalit Saini, Jack T Seki, Deepali Kumar, Eshetu G Atenafu, David EC Cole, Betty YL Wong, Andrea Božović, Joseph M Brandwein

Publikováno v: Canadian Journal of Infectious Diseases and Medical Microbiology, Vol 25, Iss 5, Pp 271-276 (2014)

INTRODUCTION: Voriconazole plasma concentrations have been correlated with oral dosing in healthy subjects, but have been poorly characterized in ill patients with hematological malignancies receiving intensive chemotherapy.

Externí odkaz: https://doaj.org/article/6c379212e1fc49e4aa8c3acb7be885d9

Serum voriconazole level variability in patients with hematological malignancies receiving voriconazole therapy

Autor: Jack T Seki, Deepali Kumar, David E. C. Cole, Joseph Brandwein, Andrea Božović, Lalit Saini, Betty Y.L. Wong, Eshetu G. Atenafu

Publikováno v: The Canadian Journal of Infectious Diseases & Medical Microbiology
Canadian Journal of Infectious Diseases and Medical Microbiology, Vol 25, Iss 5, Pp 271-276 (2014)

Voriconazole is an important antifungal agent used to treat invasive fungal infections; however, its administration can be difficult because of the narrow range between the level required for therapeutic efficacy and the level at which there is risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bdef75fdf2ee78f3b8ea44cf7cb01be
http://europepmc.org/articles/PMC4211351

Evaluation of the warfarin-resistance polymorphism, VKORC1 Asp36Tyr, and its effect on dosage algorithms in a genetically heterogeneous anticoagulant clinic

Autor: Andrew Y. Shuen, Rita Selby, Lei Fu, Betty Y.L. Wong, David E. C. Cole

Publikováno v: Clinical Biochemistry. 45:397-401

Objectives To assess allele frequency and potential predictive value of recurrent polymorphisms affecting warfarin metabolism in an unselected patient cohort attending an anticoagulant clinic (n = 186). Design and methods Genotyping of ten SNPs in fi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b711226df68f451fceee2001e6425f0f
https://doi.org/10.1016/j.clinbiochem.2012.01.002

Calcium-Sensing Receptor (CASR) Mutations in Hypercalcemic States: Studies from a Single Endocrine Clinic Over Three Years

Autor: David E. C. Cole, Geoffrey N. Hendy, Angelantonio Notarangelo, Lucie Canaff, Francisco H. J. Yun, Alfredo Scillitani, Claudia Battista, Vito Guarnieri, Betty Y.L. Wong, Michele Sacco, Leonardo D'Agruma, Lucia Anna Muscarella

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 95:1819-1829

Context: Inactivating mutations of the calcium-sensing receptor (CASR) are implicated in different hypercalcemic syndromes, including familial hypocalciuric hypercalcemia (FHH), primary hyperparathyroidism (PHPT), and familial isolated hyperparathyro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4400058aecc587ab48af1d3c78dd7df7
https://doi.org/10.1210/jc.2008-2430

Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation

Autor: Marko Oczak, Lei Fu, Betty Y.L. Wong, David E. C. Cole, Francisco H. J. Yun, Reinhold Vieth

Publikováno v: Clinical Biochemistry. 42:1174-1177

Background To determine the effect of vitamin D binding protein (DBP) genotypes on 25-hydroxyvitamin D [25(OH)D] changes with vitamin D supplements, we studied 98 adults receiving 600 or 4000 IU/d vitamin D3 for one year. Methods The DBP functional v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b4170cd4be11abcfe6a81d4b37f600
https://doi.org/10.1016/j.clinbiochem.2009.03.008