Zobrazeno 1 - 10
of 311
pro vyhledávání: '"Betty A, Eipper"'
Structure of the Sec14 domain of Kalirin reveals a distinct class of lipid-binding module in RhoGEFs
Autor:
Yunfeng Li, Yulia Pustovalova, Tzanko I. Doukov, Jeffrey C. Hoch, Richard E. Mains, Betty A. Eipper, Bing Hao
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
A subset of Sec14 domain proteins use their gated hydrophobic pocket to bind and transport lipids. Here the authors provide structural and biochemical data revealing how the Sec14-fold of a Rho-GEF forms a surface groove that interacts with lysolipid
Externí odkaz:
https://doaj.org/article/80af06883c19465389b6d3b1a530d758
Autor:
Giampaolo Trivellin, Adrian F. Daly, Laura C. Hernández-Ramírez, Elisa Araldi, Christina Tatsi, Ryan K. Dale, Gus Fridell, Arjun Mittal, Fabio R. Faucz, James R. Iben, Tianwei Li, Eleonora Vitali, Stanko S. Stojilkovic, Peter Kamenicky, Chiara Villa, Bertrand Baussart, Prashant Chittiboina, Camilo Toro, William A. Gahl, Erica A. Eugster, Luciana A. Naves, Marie-Lise Jaffrain-Rea, Wouter W. de Herder, Sebastian JCMM Neggers, Patrick Petrossians, Albert Beckers, Andrea G. Lania, Richard E. Mains, Betty A. Eipper, Constantine A. Stratakis
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionPituitary adenomas (PAs) are common, usually benign tumors of the anterior pituitary gland which, for the most part, have no known genetic cause. PAs are associated with major clinical effects due to hormonal dysregulation and tumoral imp
Externí odkaz:
https://doaj.org/article/a30ad5f4cae84c6c862ca43129169b04
Publikováno v:
BMC Neuroscience, Vol 18, Iss 1, Pp 1-11 (2017)
Abstract Background Mice lacking Kalirin-7 (Kal7KO), a Rho GDP/GTP exchange factor, self-administer cocaine at a higher rate than wildtype mice, and show an exaggerated locomotor response to experimenter-administered cocaine. Kal7, which localizes to
Externí odkaz:
https://doaj.org/article/e66183c1c4de4dafaa4c82dca66e6d2e
Publikováno v:
PLoS Biology, Vol 17, Iss 12, p e3000566 (2019)
Peptide-based intercellular communication is a ubiquitous and ancient process that predates evolution of the nervous system. Cilia are essential signaling centers that both receive information from the environment and secrete bioactive extracellular
Externí odkaz:
https://doaj.org/article/4b8474a6286c4c6ca888d79f0b32b779
Publikováno v:
British Journal of Pharmacology. 179:3306-3324
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01bb0bfd959bfb25f64a5e4e932a9118
https://doi.org/10.1111/bph.15815
https://doi.org/10.1111/bph.15815
Autor:
Giampaolo Trivellin, Adrian F. Daly, Laura C. Hernández-Ramírez, Elisa Araldi, Christina Tatsi, Ryan K. Dale, Gus Fridell, Arjun Mittal, Fabio R. Faucz, James R. Iben, Tianwei Li, Eleonora Vitali, Stanko S. Stojilkovic, Peter Kamenicky, Chiara Villa, Bertrand Baussart, Prashant Chittiboina, Camilo Toro, William A. Gahl, Erica A. Eugster, Luciana A. Naves, Marie-Lise Jaffrain-Rea, Wouter W. de Herder, Sebastian JCMM Neggers, Patrick Petrossians, Albert Beckers, Andrea G. Lania, Richard E. Mains, Betty A. Eipper, Constantine A. Stratakis
Publikováno v:
medRxiv
Pituitary adenomas (PAs) are common, usually benign tumors of the anterior pituitary gland which, for the most part, have no known genetic cause. PAs are associated with major clinical effects due to hormonal dysregulation and tumoral impingement on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f8050d2a30a58b9ba340adbc1ceb13
https://doi.org/10.1101/2023.01.20.23284646
https://doi.org/10.1101/2023.01.20.23284646
Autor:
Dhivya Kumar, Daniela Strenkert, Ramila S Patel-King, Michael T Leonard, Sabeeha S Merchant, Richard E Mains, Stephen M King, Betty A Eipper
Publikováno v:
eLife, Vol 6 (2017)
The pathways controlling cilium biogenesis in different cell types have not been fully elucidated. We recently identified peptidylglycine α-amidating monooxygenase (PAM), an enzyme required for generating amidated bioactive signaling peptides, in Ch
Externí odkaz:
https://doaj.org/article/2f90b2d4915f465aaa13b927be8c931a
Publikováno v:
The FEBS Journal. 289:4470-4496
Our understanding of the ways in which peptides are used for communication in the nervous and endocrine systems began with the identification of oxytocin, vasopressin and insulin, each of which is stored in electron dense granules, ready for release
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb9676bcf788c1828a66bf684b1d61b
https://doi.org/10.1111/febs.16049
https://doi.org/10.1111/febs.16049
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Cilia are sensory and secretory organelles that both receive information from the environment and transmit signals. Cilia-derived vesicles (ectosomes), formed by outward budding of the ciliary membrane, carry enzymes and other bioactive products; thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcdf850f7d3007747ff3613add28719e
https://doi.org/10.1073/pnas.2206098119
https://doi.org/10.1073/pnas.2206098119
Structure of the Sec14 domain of Kalirin reveals a distinct class of lipid-binding module in RhoGEFs
Autor:
Yunfeng, Li, Yulia, Pustovalova, Tzanko I, Doukov, Jeffrey C, Hoch, Richard E, Mains, Betty A, Eipper, Bing, Hao
Publikováno v:
Nature communications. 14(1)
Gated entry of lipophilic ligands into the enclosed hydrophobic pocket in stand-alone Sec14 domain proteins often links lipid metabolism to membrane trafficking. Similar domains occur in multidomain mammalian proteins that activate small GTPases and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3615a9e9ff71f2c994226b9f6779b702
https://pubmed.ncbi.nlm.nih.gov/36609407
https://pubmed.ncbi.nlm.nih.gov/36609407