Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Betty, Hakkert"'
Autor:
Damiën, van Berlo, Marjolijn, Woutersen, Andre, Muller, Marja, Pronk, Jelle, Vriend, Betty, Hakkert
The concept of the Maximum Tolerated Dose (MTD) was introduced in the seventies for carcinogenicity testing and was defined as the highest dose inducing clear toxicity, but not mortality by causes other than cancer. As estimation of the MTD in a carc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bdb81b7caf2b10d977cf6392566afc3
http://hdl.handle.net/10029/626018
http://hdl.handle.net/10029/626018
Autor:
Damiën van Berlo, Marjolijn Woutersen, Andre Muller, Marja Pronk, Jelle Vriend, Betty Hakkert
Publikováno v:
Regulatory Toxicology and Pharmacology. 139:105366
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6e72211f7a011c11f18f3934d640936
https://doi.org/10.1016/j.yrtph.2023.105366
https://doi.org/10.1016/j.yrtph.2023.105366
Publikováno v:
ALTEX.
In vitro toxicokinetic data are critical in meeting an increased regulatory need to improve chemical safety evaluations towards a better understanding of internal human chemical exposure and toxicity. In vitro intrinsic hepatic clearance (CLint), the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ad18fc6e33ddb3e27b9594dd712659
https://doi.org/10.14573/altex.2202131
https://doi.org/10.14573/altex.2202131
Publikováno v:
ALTEX.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af1013d6ac5b267438ac3c088ff9982d
https://doi.org/10.14573/altex.2107091
https://doi.org/10.14573/altex.2107091