Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Bettina Zierfuss"'
Autor:
Isabelle Weinhofer, Paulus Rommer, Andreas Gleiss, Markus Ponleitner, Bettina Zierfuss, Petra Waidhofer-Söllner, Stéphane Fourcade, Katharina Grabmeier-Pfistershammer, Marie-Christine Reinert, Jens Göpfert, Anne Heine, Hemmo A.F. Yska, Carlos Casasnovas, Verónica Cantarín, Caroline G. Bergner, Eric Mallack, Sonja Forss-Petter, Patrick Aubourg, Annette Bley, Marc Engelen, Florian Eichler, Troy C. Lund, Aurora Pujol, Wolfgang Köhler, Jörn-Sven Kühl, Johannes Berger
Publikováno v:
EBioMedicine, Vol 96, Iss , Pp 104781- (2023)
Summary: Background: X-linked adrenoleukodystrophy (X-ALD) is highly variable, ranging from slowly progressive adrenomyeloneuropathy to severe brain demyelination and inflammation (cerebral ALD, CALD) affecting males with childhood peak onset. Risk m
Externí odkaz:
https://doaj.org/article/275297f07de64a75ad4b82604a75b650
Autor:
Bettina Zierfuss, Agnieszka Buda, Andrea Villoria-González, Maxime Logist, Jure Fabjan, Patricia Parzer, Claire Battin, Streggi Vandersteene, Inge M. E. Dijkstra, Petra Waidhofer-Söllner, Katharina Grabmeier-Pfistershammer, Peter Steinberger, Stephan Kemp, Sonja Forss-Petter, Johannes Berger, Isabelle Weinhofer
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-20 (2022)
Abstract Saturated very long-chain fatty acids (VLCFA, ≥ C22), enriched in brain myelin and innate immune cells, accumulate in X-linked adrenoleukodystrophy (X-ALD) due to inherited dysfunction of the peroxisomal VLCFA transporter ABCD1. In its sev
Externí odkaz:
https://doaj.org/article/28432a9f70e04eb791392053b1e9a1b7
Autor:
Andrea Villoria-González, Bettina Zierfuss, Patricia Parzer, Elisabeth Heuböck, Violetta Zujovic, Petra Waidhofer-Söllner, Markus Ponleitner, Paulus Rommer, Jens Göpfert, Sonja Forss-Petter, Johannes Berger, Isabelle Weinhofer
Publikováno v:
Biomolecules, Vol 13, Iss 12, p 1696 (2023)
Elevated levels of saturated very long-chain fatty acids (VLCFAs) in cell membranes and secreted lipoparticles have been associated with neurotoxicity and, therefore, require tight regulation. Excessive VLCFAs are imported into peroxisomes for degrad
Externí odkaz:
https://doaj.org/article/85a80d74490841eab82e2d3039ddc133
Autor:
Isabelle Weinhofer, Paulus Rommer, Bettina Zierfuss, Patrick Altmann, Martha Foiani, Amanda Heslegrave, Henrik Zetterberg, Andreas Gleiss, Patricia L. Musolino, Yi Gong, Sonja Forss-Petter, Thomas Berger, Florian Eichler, Patrick Aubourg, Wolfgang Köhler, Johannes Berger
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
X-linked adrenoleukodystophy (X-ALD) is a highly variable, progressive neurodegenerative disorder. In this study, neurofilament light chain protein (NfL) was identified as a potential early distinguishing biomarker.
Externí odkaz:
https://doaj.org/article/bc793312378441c5a3bc5301eb2c1762
Autor:
Bettina Zierfuss, Isabelle Weinhofer, Agnieszka Buda, Niko Popitsch, Lena Hess, Verena Moos, Simon Hametner, Stephan Kemp, Wolfgang Köhler, Sonja Forss‐Petter, Christian Seiser, Johannes Berger
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 11, Pp 2161-2177 (2020)
Abstract Objective To assess class I‐histone deacetylase (HDAC) inhibition on formation of lipid‐accumulating, disease‐promoting phagocytes upon myelin load in vitro, relevant for neuroinflammatory disorders like multiple sclerosis (MS) and cer
Externí odkaz:
https://doaj.org/article/40f371d81c5841558e4739b6c421dc16
Autor:
Bettina Zierfuss, Isabelle Weinhofer, Jörn‐Sven Kühl, Wolfgang Köhler, Annette Bley, Katharina Zauner, Johannes Binder, Ksenija Martinović, Christian Seiser, Christoph Hertzberg, Stephan Kemp, Gerda Egger, Gerda Leitner, Jan Bauer, Christoph Wiesinger, Markus Kunze, Sonja Forss‐Petter, Johannes Berger
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 5, Pp 639-652 (2020)
Abstract Objective To identify a pharmacological compound targeting macrophages, the most affected immune cells in inflammatory X‐linked adrenoleukodystrophy (cerebral X‐ALD) caused by ABCD1 mutations and involved in the success of hematopoietic
Externí odkaz:
https://doaj.org/article/25a19368269e4040bd9f1f687a1e1952
Autor:
Marc Charabati, Stephanie Zandee, Antoine P Fournier, Olivier Tastet, Karine Thai, Roxaneh Zaminpeyma, Marc-André Lécuyer, Lyne Bourbonnière, Sandra Larouche, Wendy Klement, Camille Grasmuck, Fiona Tea, Bettina Zierfuss, Ali Filali-Mouhim, Robert Moumdjian, Alain Bouthillier, Romain Cayrol, Evelyn Peelen, Nathalie Arbour, Catherine Larochelle, Alexandre Prat
Publikováno v:
Brain. 146:1483-1495
The trafficking of autoreactive leucocytes across the blood–brain barrier endothelium is a hallmark of multiple sclerosis pathogenesis. Although the blood–brain barrier endothelium represents one of the main CNS borders to interact with the infil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc336d30eeb0f8febc94fb723d174b8
https://doi.org/10.1093/brain/awac389
https://doi.org/10.1093/brain/awac389
Autor:
Isabelle Weinhofer, Simon Hametner, Johannes Berger, Wolfgang Köhler, Lena Hess, Verena Moos, Niko Popitsch, Bettina Zierfuss, Agnieszka Buda, Christian Seiser, Sonja Forss-Petter, Stephan Kemp
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 11, Pp 2161-2177 (2020)
Annals of Clinical and Translational Neurology
Annals of clinical and translational neurology, 7(11), 2161-2177. John Wiley and Sons Ltd
Annals of Clinical and Translational Neurology
Annals of clinical and translational neurology, 7(11), 2161-2177. John Wiley and Sons Ltd
Objective To assess class I‐histone deacetylase (HDAC) inhibition on formation of lipid‐accumulating, disease‐promoting phagocytes upon myelin load in vitro, relevant for neuroinflammatory disorders like multiple sclerosis (MS) and cerebral X
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36cd9cdcffe5e287ede23e20af86d85
https://doaj.org/article/40f371d81c5841558e4739b6c421dc16
https://doaj.org/article/40f371d81c5841558e4739b6c421dc16
Autor:
Isabelle Weinhofer, Paulus Rommer, Bettina Zierfuss, Patrick Altmann, Martha Foiani, Amanda Heslegrave, Henrik Zetterberg, Andreas Gleiss, Patricia L. Musolino, Yi Gong, Sonja Forss-Petter, Thomas Berger, Florian Eichler, Patrick Aubourg, Wolfgang Köhler, Johannes Berger
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
X-linked adrenoleukodystrophy (X-ALD), the most frequent monogenetic disorder of brain white matter, is highly variable, ranging from slowly progressive adrenomyeloneuropathy (AMN) to life-threatening inflammatory brain demyelination (CALD). In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8cae8a8dae4911a4e56af4abe495fd60
https://pubmed.ncbi.nlm.nih.gov/33753741
https://pubmed.ncbi.nlm.nih.gov/33753741
Autor:
Isabelle, Weinhofer, Bettina, Zierfuss, Simon, Hametner, Magdalena, Wagner, Niko, Popitsch, Christian, Machacek, Barbara, Bartolini, Gerhard, Zlabinger, Anna, Ohradanova-Repic, Hannes, Stockinger, Wolfgang, Köhler, Romana, Höftberger, Günther, Regelsberger, Sonja, Forss-Petter, Hans, Lassmann, Johannes, Berger
Publikováno v:
Brain
Weinhofer et al. reveal impaired plasticity of macrophages, with intrinsic pro-inflammatory skewing and a decreased ability to establish proper anti-inflammatory responses, in X-linked adrenoleukodystrophy (ALD). This may contribute to the rapidly pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e7b013c0e2f6169d4bb21becee720779
https://pubmed.ncbi.nlm.nih.gov/29860501
https://pubmed.ncbi.nlm.nih.gov/29860501