Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Bettina Winckler"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Proper wiring of the peripheral nervous system relies on neurotrophic signaling via nerve growth factor (NGF). NGF secreted by target organs (i.e. eye) binds to the TrkA receptor expressed on the distal axons of postganglionic neurons. Upon
Externí odkaz:
https://doaj.org/article/6eeab11b19644fb2a5daca8a7e239394
Autor:
Chan Choo Yap, Bettina Winckler
Publikováno v:
Autophagy Reports, Vol 1, Iss 1, Pp 570-575 (2022)
Dendrites differ from axons in multiple ways, including the presence of minus-end out microtubules intermixed with the more conventional plus-end out microtubules. The mixed microtubule polarity makes regulation of directional transport in dendrites
Externí odkaz:
https://doaj.org/article/c77bd08538bf415c8076dc6719bc849a
Publikováno v:
Bio-Protocol, Vol 13, Iss 10 (2023)
Live imaging is commonly used to study dynamic processes in cells. Many labs carrying out live imaging in neurons use kymographs as a tool. Kymographs display time-dependent microscope data (time-lapsed images) in two-dimensional representations show
Externí odkaz:
https://doaj.org/article/801f5e7909224c58a1e8ff1136ee99fd
Autor:
Ryan J. Mulligan, Bettina Winckler
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1399 (2023)
Intracellular endosomal trafficking controls the balance between protein degradation and synthesis, i.e., proteostasis, but also many of the cellular signaling pathways that emanate from activated growth factor receptors after endocytosis. Endosomal
Externí odkaz:
https://doaj.org/article/8fac3cb94ae84540a9dbcffc2be99c4b
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140010 (2015)
The brain consists of many distinct neuronal cell types, but which cell types are present in widely used primary cultures of embryonic rodent brain is often not known. We characterized how abundantly four cell type markers (Ctip2, Satb2, Prox1, GAD65
Externí odkaz:
https://doaj.org/article/10fdb06696a8474d80f955e1d9d34196
Publikováno v:
bioRxiv
In neurons, degradation of dendritic cargos requires RAB7 and dynein-mediated retrograde transport to somatic lysosomes. In order to test if the dynein adaptor RILP (RAB-interacting lysosomal protein) mediated the recruitment of dynein to late endoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fce1f7882969a2610ae6f2ba6a6ec6
https://europepmc.org/articles/PMC10028860/
https://europepmc.org/articles/PMC10028860/
Publikováno v:
J Neurosci
In all cell types, endocytosed cargo is transported along a set of endosomal compartments, which are linked maturationally from early endosomes (EEs) via late endosomes (LEs) to lysosomes. Lysosomes are critical for degradation of proteins that enter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b588a5788314627a9e2bbf4b4bbf32
https://doi.org/10.1523/jneurosci.2530-21.2022
https://doi.org/10.1523/jneurosci.2530-21.2022
Publikováno v:
Methods in Molecular Biology ISBN: 9781071626382
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2d6e0aa40540409f47f6147df9d50fd
https://doi.org/10.1007/978-1-0716-2639-9_36
https://doi.org/10.1007/978-1-0716-2639-9_36
RILP is one of many effectors of RAB7 which bind to RAB7 in its activated GTP-bound state. The exact mechanism by which RAB7 effectors interact with RAB7 in time and space is not well understood. One of the known functions of RILP is to recruit dynei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8ee14f4ea555a5162637beb4a734f46
https://doi.org/10.1101/2022.11.01.514750
https://doi.org/10.1101/2022.11.01.514750
Publikováno v:
The Neuroscientist. :107385842311605
Extracellular vesicles (EVs) are secreted from most, if not all, cell types and are implicated in short- and long-distance signaling throughout the body. EVs are also secreted from neurons and represent an emergent neuronal communication platform. Un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b3b422eba9285d22e0c9de6c0888c39
https://doi.org/10.1177/10738584231160521
https://doi.org/10.1177/10738584231160521