Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Bettina Schaible"'
Autor:
Caitríona Hickey, Bettina Schaible, Scott Nguyen, Daniel Hurley, Shabarinath Srikumar, Séamus Fanning, Eric Brown, Bianca Crifo, David Matallanas, Siobhán McClean, Cormac T. Taylor, Kirsten Schaffer
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)
The factors influencing the virulence of P. aeruginosa in the development of invasive infection remain poorly understood. Here, we investigated the role of the host microenvironment in shaping pathogen virulence and investigated the mechanisms involv
Externí odkaz:
https://doaj.org/article/adcaf4dce143402196a01b3f82dae03e
Autor:
Matthias Tacke, Bettina Schaible, Siddappa Patil, Francesca Paradisi, Frauke Hackenberg, Claire Healy, Stephen V. Gordon, Michael A. Sharkey, James P. O'Gara
Publikováno v:
Antibiotics, Vol 1, Iss 1, Pp 25-28 (2012)
The synthesis of N-heterocyclic carbene (NHC) silver(I) acetate complexes with varying lipophilic benzyl-substituents at the 1 and 3 positions starting from 4,5-diphenylimidazole, opened a new class of antibiotic drug candidates. These NHC-silver(I)
Externí odkaz:
https://doaj.org/article/ba20f40b98bd43dd8792d3d10631e3dd
Autor:
Bettina Schaible, Siobhán McClean, Andrew Selfridge, Alexis Broquet, Karim Asehnoune, Cormac T Taylor, Kirsten Schaffer
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56491 (2013)
Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen commonly associated with lung and wound infections. Hypoxia is a frequent feature of the microenvironment of infected tissues which induces the expression of genes associated with in
Externí odkaz:
https://doaj.org/article/f9bae7f91fbc484881194735982ee4a1
Publikováno v:
Journal of Biological Chemistry. 295:1195-1201
Publikováno v:
Journal of Biological Chemistry. 295:1195-1201
Pseudomonas aeruginosa is an extracellular opportunistic bacterial pathogen commonly associated with infectious complications in susceptible individuals, such as those with underlying diseases including HIV/AIDS and cystic fibrosis. Antibiotic resist
Publikováno v:
J Biol Chem
Pseudomonas aeruginosa is an extracellular opportunistic bacterial pathogen commonly associated with infectious complications in susceptible individuals, such as those with underlying diseases including HIV/AIDS and cystic fibrosis. Antibiotic resist
Autor:
Daniel Crean, Antonella Naldini, Carsten C. Scholz, Bettina Schaible, Zsolt Fábián, Helen M. Roche, Susan F. Fitzpatrick, Hugh E. Giffney, Doug N. Halligan, Bianca Crifo, Alfonso Blanco, Anna M. Kirwan, Miguel Cavadas, Mattia Criscuoli, Eoin P. Cummins, Eric Brown, Cormac T. Taylor
Hypoxia is a common and prominent feature of the microenvironment at sites of bacteria-associated inflammation in inflammatory bowel disease. The prolyl-hydroxylases (PHD1/2/3) and the asparaginyl-hydroxylase factor-inhibiting HIF are oxygen-sensing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00d39b33c612dbb0718e36ea61dfc5a5
https://www.zora.uzh.ch/id/eprint/169137/
https://www.zora.uzh.ch/id/eprint/169137/
Autor:
Claire Healy, Francesca Paradisi, Matthias Tacke, Michael A. Sharkey, Frauke Hackenberg, Siddappa A. Patil, James P. O'Gara, Bettina Schaible, Stephen V. Gordon
Publikováno v:
Antibiotics
Antibiotics, Vol 1, Iss 1, Pp 25-28 (2012)
Antibiotics, Vol 1, Iss 1, Pp 25-28 (2012)
The synthesis of N-heterocyclic carbene (NHC) silver(I) acetate complexes with varying lipophilic benzyl-substituents at the 1 and 3 positions starting from 4,5-diphenylimidazole, opened a new class of antibiotic drug candidates. These NHC-silver(I)
Autor:
Susan F. Fitzpatrick, Mario C. Manresa, Zsolt Fábián, Alex von Kriegsheim, Cormac T. Taylor, Peter Carmeliet, Yvonne M. O'Meara, Glen Doherty, Zongwei Li, Peter Fraisl, Eoin P. Cummins, Bettina Schaible, Murtaza M. Tambuwala, Myriam Baes, Craig Slattery, Ulrike Bruning, Javier Rodriguez, Xingnan Zheng, Colin R. Lenihan, Desmond G. Higgins, Thomas Schwarzl
Publikováno v:
Fitzpatrick, S F, Fábián, Z, Schaible, B, Lenihan, C R, Schwarzl, T, Rodriguez, J, Zheng, X, Li, Z, Tambuwala, M M, Higgins, D G, O'Meara, Y, Slattery, C, Manresa, M C, Fraisl, P, Bruning, U, Baes, M, Carmeliet, P, Doherty, G, von Kriegsheim, A, Cummins, E P & Taylor, C T 2016, ' Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-κB-dependent manner ', Biochemical and Biophysical Research Communications, vol. 474, no. 3, pp. 579-86 . https://doi.org/10.1016/j.bbrc.2016.04.085
Hepatocyte death is an important contributing factor in a number of diseases of the liver. PHD1 confers hypoxic sensitivity upon transcription factors including the hypoxia inducible factor (HIF) and nuclear factor-kappaB (NF-κB). Reduced PHD1 activ
Publikováno v:
Respiratory Physiology & Neurobiology. 174:235-243
The mucosal surface of the lung is the key interface between the external atmosphere and the bloodstream. Normally, this well oxygenated tissue is maintained in state of sterility by a number of innate immune processes. These include a physical and d