Zobrazeno 1 - 10
of 138
pro vyhledávání: '"Bettina Platt"'
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 1008 (2024)
One aspect of reproducibility in preclinical research that is frequently overlooked is the physical condition in which physiological, pharmacological, or behavioural recordings are conducted. In this study, the physical conditions of mice were altere
Externí odkaz:
https://doaj.org/article/30cbaf1efa904314b2d2e7b0e7ee7522
Autor:
Katharina Aulehner, Jack Bray, Ines Koska, Claudia Pace, Rupert Palme, Matthias Kreuzer, Bettina Platt, Thomas Fenzl, Heidrun Potschka
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Electrophysiological recordings in animals constitute frequently applied techniques to study neuronal function. In this context, several authors described tethered recordings as a semi-restraint situation with negative implications for anima
Externí odkaz:
https://doaj.org/article/0d1dadbe7cba48059f93604ceca58d4b
Publikováno v:
Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-17 (2020)
Abstract Background Lipid dysregulation is associated with several key characteristics of Alzheimer’s disease (AD), including amyloid-β and tau neuropathology, neurodegeneration, glucose hypometabolism, as well as synaptic and mitochondrial dysfun
Externí odkaz:
https://doaj.org/article/933b20ad671746a58c50281520036f2b
Publikováno v:
AIMS Neuroscience, Vol 7, Iss 1, Pp 1-16 (2020)
Delirium is an under-diagnosed yet frequently occurring clinical complication with potentially serious consequences for intensive care unit (ICU) patients. Diagnosis is currently reactive and based upon qualitative assessment of the patient’s cogni
Externí odkaz:
https://doaj.org/article/77b5e8f29ef0420991d0fa1ffdc26924
Publikováno v:
Aging Brain, Vol 2, Iss , Pp 100055- (2022)
The canonical role of Apolipoprotein E (ApoE) is related to lipid and cholesterol metabolism, however, additional functions of this protein have not been fully described. Given the association of ApoE with diseases such as Alzheimer’s Disease (AD),
Externí odkaz:
https://doaj.org/article/3402197225de4605a3125712b4061a97
Autor:
Mosi Li, Akihiro Kitamura, Joshua Beverley, Juraj Koudelka, Jessica Duncombe, Ross Lennen, Maurits A. Jansen, Ian Marshall, Bettina Platt, Ulrich K. Wiegand, Roxana O. Carare, Rajesh N. Kalaria, Jeffrey J. Iliff, Karen Horsburgh
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2022)
Large vessel disease and carotid stenosis are key mechanisms contributing to vascular cognitive impairment (VCI) and dementia. Our previous work, and that of others, using rodent models, demonstrated that bilateral common carotid stenosis (BCAS) lead
Externí odkaz:
https://doaj.org/article/24b532b621764d6c85fdb1fb3b919ba1
Autor:
David J. Koss, Lianne Robinson, Benjamin D. Drever, Kaja Plucińska, Sandra Stoppelkamp, Peter Veselcic, Gernot Riedel, Bettina Platt
Publikováno v:
Neurobiology of Disease, Vol 91, Iss , Pp 105-123 (2016)
Models of Tau pathology related to frontotemporal dementia (FTD) are essential to determine underlying neurodegenerative pathologies and resulting tauopathy relevant behavioural changes. However, existing models are often limited in their translation
Externí odkaz:
https://doaj.org/article/637aa105c06c45789fb3f244d3e47f16
Autor:
Benjamin D. Drever, William G.L. Anderson, Gernot Riedel, Dong Hyun Kim, Jong Hoon Ryu, Deog-Young Choi, Bettina Platt
Publikováno v:
Journal of Pharmacological Sciences, Vol 107, Iss 4, Pp 380-392 (2008)
The precise causative factors in neurodegenerative diseases such as Alzheimer’s (AD) and Parkinson’s disease remain elusive, but mechanisms implicated comprise excitotoxicity, mitochondrial dysfunction, and in the case of AD, the amyloid beta pep
Externí odkaz:
https://doaj.org/article/b640bae7bb6340a4943b7263c5961710
Autor:
Bettina Platt, Benjamin Drever, David Koss, Sandra Stoppelkamp, Amar Jyoti, Andrea Plano, Aneli Utan, Georgina Merrick, Duncan Ryan, Valeria Melis, Hong Wan, Marco Mingarelli, Emanuele Porcu, Louise Scrocchi, Andy Welch, Gernot Riedel
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27068 (2011)
Late-stage neuropathological hallmarks of Alzheimer's disease (AD) are β-amyloid (βA) and hyperphosphorylated tau peptides, aggregated into plaques and tangles, respectively. Corresponding phenotypes have been mimicked in existing transgenic mice,
Externí odkaz:
https://doaj.org/article/eb83b209553540a58503fbc30b7b2154
Autor:
Matteo Santoro, Paola Fadda, Katie J. Klephan, Claire Hull, Peter Teismann, Bettina Platt, Gernot Riedel
Publikováno v:
Journal of Neurochemistry. 164:121-142
Parkinson's disease (PD) is a heterogeneous multi-systemic disorder unique to humans characterized by motor and non-motor symptoms. Preclinical experimental models of PD present limitations and inconsistent neurochemical, histological, and behavioral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0bee3098f004f253796aa5e49ab677c
https://doi.org/10.1111/jnc.15699
https://doi.org/10.1111/jnc.15699