Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Bettina P. Mihalas"'
Autor:
Cerys E. Currie, Emma Ford, Lucy Benham Whyte, Deborah M. Taylor, Bettina P. Mihalas, Muriel Erent, Adele L. Marston, Geraldine M. Hartshorne, Andrew D. McAinsh
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Human beings arise from serial mitotic divisions of a single fertilised egg. Here through live cell imaging of fertilized embryos the authors show that the first mitotic division is error prone and can contribute to preimplantation mosaicism.
Externí odkaz:
https://doaj.org/article/070a5d4d39354b38a6e1e9964ca0f05e
Autor:
Bettina P. Mihalas, Geoffry N. De Iuliis, Kate A. Redgrove, Eileen A. McLaughlin, Brett Nixon
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
Abstract An increase in intraovarian reactive oxygen species (ROS) has long been implicated in the decline in oocyte quality associated with maternal ageing. Oxidative stress (OS)-induced lipid peroxidation and the consequent generation of highly ele
Externí odkaz:
https://doaj.org/article/79e822f8b2ff4b32b81bf9e9780339cf
Autor:
Amanda L. Anderson, Simone J. Stanger, Bettina P. Mihalas, Sonika Tyagi, Janet E. Holt, Eileen A. McLaughlin, Brett Nixon
Publikováno v:
Genomics Data, Vol 6, Iss C, Pp 208-211 (2015)
The mammalian epididymis is a highly specialized region of the male reproductive tract that is lined with a continuous layer of epithelial cells that display a remarkable level of regionalized secretory and absorptive activity. The luminal environmen
Externí odkaz:
https://doaj.org/article/fe1911a1fe1e487999289fcdf63f6bc5
Autor:
Bettina P Mihalas, Gerard H Pieper, Cerys E Currie, David A Kelly, Geraldine M Hartshorne, Andrew D McAinsh, Richard A Anderson, Adele L Marston
Aneuploid human eggs (oocytes) are a major cause of infertility, miscarriage and chromosomal disorders. Such aneuploidies increase greatly as women age, originating from defective linkages between sister-chromatids (cohesion) in meiosis. We found evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8aba372407f70b532f47644e9d946d2
https://doi.org/10.1101/2023.01.13.523952
https://doi.org/10.1101/2023.01.13.523952
Autor:
Eileen A. McLaughlin, Jessie M. Sutherland, Bettina P. Mihalas, Brett Nixon, Ilana R. Bernstein, Mark J. Robertson, Kate A. Redgrove, Adam McCluskey, Janet E. Holt
Publikováno v:
The FASEB Journal. 34:5162-5177
During folliculogenesis, oocytes are dependent on metabolic and molecular support from surrounding somatic cells. Here, we examined the role of the dynamin (DNM) family of mechanoenzymes in mediating endocytotic uptake into growing follicular oocytes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e43741174a620ef6612e36bb0d66f3
https://doi.org/10.1096/fj.201902184r
https://doi.org/10.1096/fj.201902184r
Autor:
Alison J. Carey, Alison R Mooney, Kate A. Redgrove, Kristofor Bogoevski, Eileen A. McLaughlin, Bettina P. Mihalas, Ella Palframan, Kenneth W. Beagley, Gemma Trollope, Jessie M. Sutherland, Peter Mulvey, Robert I McLachlan, Charles W. Armitage, Avinash Kollipara, Emily R Bryan, Logan K Trim
Publikováno v:
Biology of Reproduction
With approximately 131 million new genital tract infections occurring each year, Chlamydia is the most common sexually transmitted bacterial pathogen worldwide. Male and female infections occur at similar rates and both cause serious pathological seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d285a037c839e090ed8d939e9cdb723
https://doi.org/10.1093/biolre/ioz229
https://doi.org/10.1093/biolre/ioz229
Autor:
R. John Aitken, Bettina P. Mihalas, Elizabeth G. Bromfield, Brett Nixon, Eileen A. McLaughlin, Jessica L H Walters, Matthew D. Dun
Publikováno v:
Biology of Reproduction. 96:598-609
Lipid peroxidation products, such as 4-hydroxynonenal (4HNE), are causative agents responsible for extensive protein damage within the male and female germlines. Recently, we have demonstrated that 4HNE production can initiate the proteolytic degrada
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94d060129e77186c963c1cb1709c5b63
https://doi.org/10.1093/biolre/iox005
https://doi.org/10.1093/biolre/iox005
Publikováno v:
REPRODUCTION. 150:485-496
Mammalian oocyte growth and development is driven by a strict program of gene expression that relies on the timely presence of transcriptional regulators via nuclear pores. By targeting specific cargos for nucleo-cytoplasmic transport, karyopherin (K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d9650d89f5f3632222b1f75a6b0a83
https://doi.org/10.1530/rep-14-0585
https://doi.org/10.1530/rep-14-0585
Autor:
Eileen A. McLaughlin, R. John Aitken, Bettina P. Mihalas, Elizabeth G. Bromfield, Brett Nixon, Geoffry N. De Iuliis, Jessie M. Sutherland
An increase in oxidative protein damage is a leading contributor to the age-associated decline in oocyte quality. By removing such damaged proteins, the proteasome plays an essential role in maintaining the fidelity of oocyte meiosis. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba77aadee5b1cded8e10b74bc3c9e3a
https://europepmc.org/articles/PMC6295717/
https://europepmc.org/articles/PMC6295717/
Autor:
Kylie R. Dunning, Eileen A. McLaughlin, Natalie L Reed, Alexandra N Seldon, Bettina P. Mihalas, Darryl L Russel, Jessie M. Sutherland, Emmalee A Ford, Alexandra E. Peters, Emily R Frost
Publikováno v:
MHR: Basic science of reproductive medicine.
Study question Is the Janus kinase and signal transducer and activator of transcription (JAK-STAT) signalling pathway involved in ovarian follicle development and primordial follicle activation? Summary answer JAK1 is a key factor involved in the reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de80465ff858379c62d0b88e1828fb1d
https://doi.org/10.1093/molehr/gay041
https://doi.org/10.1093/molehr/gay041