Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Bettina M. Weigand"'
Autor:
Liam D. Cassidy, Andrew R. J. Young, Christopher N. J. Young, Elizabeth J. Soilleux, Edward Fielder, Bettina M. Weigand, Anthony Lagnado, Rebecca Brais, Nicholas T. Ktistakis, Kimberley A. Wiggins, Katerina Pyrillou, Murray C. H. Clarke, Diana Jurk, Joao F. Passos, Masashi Narita
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Autophagy declines with age, yet it is unclear if restoration of autophagy extends lifespan. Here, the authors demonstrate in murine models that the inhibition of Atg5 induces ageing phenotypes and reduces lifespan, whilst autophagy restoration parti
Externí odkaz:
https://doaj.org/article/08d9c43fad6f4fa996ca4382c883b9dc
Autor:
João F. Passos, Anthony B. Lagnado, Elizabeth J. Soilleux, Katerina Pyrillou, Rebecca Brais, Nicholas T. Ktistakis, Liam D. Cassidy, Diana Jurk, Bettina M. Weigand, Masashi Narita, Murray C.H. Clarke, Kimberley A. Wiggins, Edward Fielder, Andrew R. J. Young, Christopher N. J. Young
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Autophagy is an important cellular degradation pathway with a central role in metabolism as well as basic quality control, two processes inextricably linked to ageing. A decrease in autophagy is associated with increasing age, yet it is unknown if th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678fc7a70f3aa7a42256be1e52835df0
http://link.springer.com/article/10.1038/s41467-019-14187-x
http://link.springer.com/article/10.1038/s41467-019-14187-x
Autor:
Yi Zhu, João F. Passos, Kurt O. Johnson, Marissa J. Schafer, Diana Jurk, Edward Fielder, Christine Inman, Bettina M. Weigand, James L. Kirkland, Mikolaj Ogrodnik, Tamar Pirtskhalava, Shane A. Evans, Nicola Neretti, Ayush D. Patel, Thomas von Zglinicki, David B. Allison, Hanna Salmonowicz, Stella Victorelli, Nathan K. LeBrasseur, Tamar Tchkonia, Patrick Krüger, Azucena Rocha, Stephanie L. Dickinson
Publikováno v:
Aging Cell
Cellular senescence is characterized by an irreversible cell cycle arrest and a pro‐inflammatory senescence‐associated secretory phenotype (SASP), which is a major contributor to aging and age‐related diseases. Clearance of senescent cells has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c913cb3dab169d1ab3ab49fad5fcf6
https://doi.org/10.1111/acel.13296
https://doi.org/10.1111/acel.13296
Autor:
João F. Passos, Liam D. Cassidy, Kimberley A. Wiggins, Rebecca Brais, Diana Jurk, Christopher N. J. Young, Masashi Narita, Edward Fielder, Andrew R. J. Young, Bettina M Weigand, Murray C.H. Clarke, Elizabeth J. Soilleux
Autophagy is an important cellular degradation pathway with a central role in metabolism as well as basic quality control, two processes inextricably linked to aging. A decrease in autophagy is associated with increasing age, yet it is unknown if thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d741b435c09772814e7f0d75b41a01
https://doi.org/10.1101/528984
https://doi.org/10.1101/528984
Autor:
Bettina M. Weigand, Christine M Hachfeld, Ming Xu, Joshua N. Farr, Xiaonan Hou, Vesna D. Garovic, Jennifer L Onken, Larissa G.P. Langhi, Tamar Pirtskhalava, Hajrunisa Cubro, Ravinder J. Singh, S. John Weroha, Megan M. Weivoda, Mikolaj Ogrodnik, Kurt O. Johnson, Keisuke Ejima, Gene B. Hubbard, Laura J. Niedernhofer, Grace C Verzosa, Diana Jurk, James L. Kirkland, Paul D. Robbins, Moritz Weigl, Christina L. Inman, Jordan D. Miller, Daniel G. Fraser, David B. Allison, Nino Giorgadze, Sundeep Khosla, Yuji Ikeno, Allyson K. Palmer, Tamara Tchkonia, Nathan K. LeBrasseur
Publikováno v:
Nature medicine
Physical function declines in old age, portending disability, increased health expenditures, and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these consequences of aging, but whether senescence can directly drive a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02db7172651264fd5240a5fe961df9ae
https://pubmed.ncbi.nlm.nih.gov/30292430
https://pubmed.ncbi.nlm.nih.gov/30292430