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Akademický článek

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.

Autor: Dmitry Ratner, M Pontus A Orning, Megan K Proulx, Donghai Wang, Mikhail A Gavrilin, Mark D Wewers, Emad S Alnemri, Peter F Johnson, Bettina Lee, Joan Mecsas, Nobuhiko Kayagaki, Jon D Goguen, Egil Lien

Publikováno v: PLoS Pathogens, Vol 12, Iss 12, p e1006035 (2016)

Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling. To counter this, innate immune responses can also sense some T3SS co

Externí odkaz: https://doaj.org/article/7e19901ed97f4246a3cd738ecfdae743

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NINJ1 mediates plasma membrane rupture during lytic cell death

Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR releases intracellular molecules termed damage-associated molecular patterns (DAMPs) that propagate the inflammatory response. The underlying mechanism for PMR, how

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c4265e0bcc26c15a90c40c49f13bfccc
https://doi.org/10.21203/rs.3.rs-62714/v1

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The Ubiquitin-Editing Enzyme A20 Restricts Nucleotide-Binding Oligomerization Domain Containing 2-Triggered Signals

Autor: Regina Celeste Ahmad, Min Wang, Barbara A. Malynn, Catherine Werts, Emre E. Turer, Dana J. Philpott, Rommel Advincula, Osamu Hitotsumatsu, Rita M. Tavares, Averil Ma, Nataliya Shiffin, Bettina Lee

Publikováno v: Immunity. 28(3):381-390

Summary Muramyl dipeptide (MDP), a product of bacterial cell-wall peptidoglycan, activates innate immune cells by stimulating nucleotide-binding oligomerization domain containing 2 (NOD2) -dependent activation of the transcription factor NFκB and tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df0475656cf7e0c48666897aa0ee3d8

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Homeostatic MyD88-dependent signals cause lethal inflammation in the absence of A20

Autor: Osamu Hitotsumatsu, Rommel Advincula, Barbara A. Malynn, Rita M. Tavares, Emre E. Turer, Nataliya Shifrin, Erwan Mortier, Averil Ma, Bettina Lee

Publikováno v: Journal of Experimental Medicine
Journal of Experimental Medicine, Rockefeller University Press, 2008, 205 (2), pp.451. ⟨10.1084/jem.20071108⟩
Journal of Experimental Medicine, 2008, 205 (2), pp.451. ⟨10.1084/jem.20071108⟩
The Journal of Experimental Medicine

International audience; Toll-like receptors (TLRs) on host cells are chronically engaged by microbial ligands during homeostatic conditions. These signals do not cause inflammatory immune responses in unperturbed mice, even though they drive innate a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec655015d273740735434b1382b423a1
https://www.hal.inserm.fr/inserm-02442492

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ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development

Autor: Shigeru, Oshima, Emre E, Turer, Joseph A, Callahan, Sophia, Chai, Rommel, Advincula, Julio, Barrera, Nataliya, Shifrin, Bettina, Lee, T S, Benedict Yen, Benjamin, Yen, Tammy, Woo, Barbara A, Malynn, Averil, Ma

Publikováno v: Nature

Proteins that directly regulate tumour necrosis factor receptor (TNFR) signalling have critical roles in regulating cellular activation and survival. ABIN-1 (A20 binding and inhibitor of NF-kappaB) is a novel protein that is thought to inhibit NF-kap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d001cead81b5d14167182ca63b29381
https://pubmed.ncbi.nlm.nih.gov/19060883

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Family and Social Attitudes across Four Generations of Women of Maternal Lineage

Autor: Bettina Lee Clebone, Claribel Mengert Taylor

Publikováno v: Psychological Reports. 70:268-270

tween chose attitudes vulnerable to environmental change and those which may be resilient and transfer across four generations of maternal lineage. Differences were noted among the four groups on their attitudes regarding children, patents, health, f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::14e17decbe4b34295f8e201187b26466
https://doi.org/10.2466/pr0.1992.70.1.268

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