Classification of α-synuclein-induced changes in the AAV α-synuclein rat model of Parkinson’s disease using electrophysiological measurements of visual processing

Autor: Freja Gam Østergaard, Marc M. Himmelberg, Bettina Laursen, Hartwig R. Siebner, Alex R. Wade, Kenneth Vielsted Christensen

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)

Abstract Biomarkers suitable for early diagnosis and monitoring disease progression are the cornerstone of developing disease-modifying treatments for neurodegenerative diseases such as Parkinson’s disease (PD). Besides motor complications, PD is a

Externí odkaz: https://doaj.org/article/0d30f39be362461791363a38bd12b9f6

Visual evoked potentials as an early-stage biomarker in the rTg4510 tauopathy mouse model

Autor: Aleksandra Parka, Christiane Volbracht, Benjamin Hall, Jesper F. Bastlund, Maiken Nedergaard, Bettina Laursen, Paolo Botta, Florence Sotty

Background: Tauopathies such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are characterized by formation of neurofibrillary tangles consisting of hyperphosphorylated tau protein. Early pathophysiological and functional changes rela

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca20943b3e2d95222ff90c9c55ba758e
https://doi.org/10.1101/2022.10.03.510063

Progressive Effects of Sildenafil on Visual Processing in Rats

Autor: Kenneth Vielsted Christensen, Alex R. Wade, Hartwig R. Siebner, Freja Gam Østergaard, Bettina Laursen

Publikováno v: Neuroscience
Østergaard, F G, Wade, A R, Siebner, H R, Christensen, K V & Laursen, B 2020, ' Progressive Effects of Sildenafil on Visual Processing in Rats ', Neuroscience, vol. 441, pp. 131-141 . https://doi.org/10.1016/j.neuroscience.2020.06.033

Photoreceptors are light-sensitive cells in the retina converting visual stimuli into electrochemical signals. These signals are evaluated and interpreted in the visual pathway, a process referred to as visual processing. Phosphodiesterase type 5 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fa24d3f131c8c147f65536d63c38ad
https://doi.org/10.1016/j.neuroscience.2020.06.033

No detectable effect on visual responses using functional mri in a rodent model of a-synuclein expression

Autor: Freja Gam Østergaard, Christian Stald Skoven, Hartwig R. Siebner, Tim B. Dyrby, Alex R. Wade, Bettina Laursen, Kenneth Vielsted Christensen

Publikováno v: Østergaard, F G, Skoven, C S, Wade, A R, Siebner, H R, Laursen, B, Christensen, K V & Dyrby, T B 2021, ' No detectable effect on visual responses using functional mri in a rodent model of a-synuclein expression ', eNeuro, vol. 8, no. 3, ENEURO.0516-20.2021, pp. 1-9 . https://doi.org/10.1523/ENEURO.0516-20.2021
eNeuro
Østergaard, F G & Skoven, C S 2021, ' No Detectable Effect on Visual Responses Using Functional MRI in a Rodent Model of α-Synuclein Expression ', eNeuro, vol. 8, no. 3, 0516-20.2021 . https://doi.org/10.1523/ENEURO.0516-20.2021
Østergaard, F G, Skoven, C S, Wade, A R, Siebner, H R, Laursen, B, Christensen, K V & Dyrby, T B 2021, ' No detectable effect on visual responses using functional mri in a rodent model of a-synuclein expression ', eNeuro, vol. 8, no. 3 . https://doi.org/10.1523/ENEURO.0516-20.2021

Parkinson’s disease (PD) is a progressive neurodegenerative disease that is typically diagnosed late in its progression. There is a need for biomarkers suitable for monitoring the disease progression at earlier stages to guide the development of no

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ccdfc61e5e5445636698d1edf919a4b
https://curis.ku.dk/portal/da/publications/no-detectable-effect-on-visual-responses-using-functional-mri-in-a-rodent-model-of-asynuclein-expression(2fb81b14-1dd6-46f4-a5d6-c5a88ead1af4).html

Phosphodiesterase type 1 inhibition alters medial prefrontal cortical activity during goal-driven behaviour and partially reverses neurophysiological deficits in the rat phencyclidine model of schizophrenia

Autor: Lars Kyhn Rasmussen, Jan Kehler, Elin Eneberg, Todor V. Gerdjikov, Jesper F. Bastlund, Jessica Hayes, Morten Langgård, Bettina Laursen

Publikováno v: Neuropharmacology. 186

Positive modulation of cAMP signalling by phosphodiesterase (PDE) inhibitors has recently been explored as a potential target for the reversal of cognitive and behavioural deficits implicating the corticoaccumbal circuit. Previous studies show that P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b597c388792164dc058ff27f11820f7f
https://pubmed.ncbi.nlm.nih.gov/33444639