Výsledky vyhledávání - "Bettina Faden"

Supplementary Table 2 from EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors

Autor: Andree Blaukat, Oliver Schadt, Frank Stieber, Ulrich Pehl, Frank Jaehrling, Dieter Dorsch, Michael Meyring, Ulrich Grädler, Claus Fittschen, Claudia Wilm, Christine Knuehl, Manja Friese-Hamim, Bettina Faden, Friedhelm Bladt

PDF file - 75K, High responsiveness of c-Met-addicted cell lines to treatment with EMD 1214063 and EMD 1204831. The impact of EMD 1214063 and EMD 1204831 on tumor cell viability (IC50) was tested in vitro, using a panel of tumor cell lines specifical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19326c3f35618f2086e6990b85bcee69
https://doi.org/10.1158/1078-0432.22451541

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Supplementary Figure 8 from EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors

PDF file - 184K, EMD 1214063 and EMD 1204831 display anti-tumor activity in HGF-dependent and HGF-independent xenograft tumor models. Mice bearing subcutaneous tumors derived from the human gastric Hs746T cell line (A and B) or the glioblastoma U87MG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03592926e46a69b8ef9743e7c67128ac
https://doi.org/10.1158/1078-0432.22451550

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Supplementary Figure 3 from EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors

PDF file - 255K, Effective inhibition of in vitro tumor cell migration by EMD 1214063 and EMD 1204831. A classical "wound healing" test was performed to assess the impact of EMD 1214063 (A) and EMD 1204831 (B) on tumor cell migration. In brief, H441

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f477947e78a52a3426f6e533a5fb5e63
https://doi.org/10.1158/1078-0432.22451568

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Supplementary Table 1 from EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors

PDF file - 53K, Characteristics of the antibodies used in the study. The specificity, isotype, clone number, and commercial source of the antibodies used throughout the study are indicated. All antibodies were used according to the manufacturer's ins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::167a2577129d987e5e7e4a54a52b7819
https://doi.org/10.1158/1078-0432.22451544.v1

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Data from EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors

Purpose: The mesenchymal–epithelial transition factor (c-Met) receptor, also known as hepatocyte growth factor receptor (HGFR), controls morphogenesis, a process that is physiologically required for embryonic development and tissue repair. Aberrant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512bb1a709a8f8c2b40276400427ec2d
https://doi.org/10.1158/1078-0432.c.6522216

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Supplementary Figure 2 from EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors

PDF file - 263K, Effects of EMD 1214063 on c-Met phosphorylation and downstream signaling molecules (see Figure 2C). EBC-1 cells were cultured in vitro in control medium (medium + vehicle) (lane 1), or in the presence of increasing concentrations of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1325f90de2a065096f938c060a024308
https://doi.org/10.1158/1078-0432.22451571.v1

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Supplementary Table 3 from EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors

PDF file - 77K, In vivo tumor growth inhibition by EMD 1214063 and EMD 1204831. The effect of EMD 1214063 and EMD 1204831 on tumor growth (T/C) was evaluated in in vivo xenograft models, using a panel of human tumor cell lines. Both inhibitors were h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db1276d7a369d4924cb438b678643d4
https://doi.org/10.1158/1078-0432.22451538.v1

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Supplementary Figure 5 from EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors

PDF file - 74K, Effective inhibition of c-Met phosphorylation in U87MG cells. To assess the pharmacodynamic activity of EMD 1214063 and EMD 1204831 in glioblastoma, U87MG glioblastoma cells were exposed for 2 h to either EMD compound. After lysis, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d07a9befe2ce555a1fc10b5f4cb45b5
https://doi.org/10.1158/1078-0432.22451562.v1

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Supplementary Figure 1 from EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors

PDF file - 45K, ATP competition studies with EMD 1214063. EMD 1214063 inhibited c-Met phosphorylation in an ATP-competitive fashion. In brief, binding competition of EMD 1214063 and ATP to c-Met was analyzed by a kinase reaction followed by Western b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4391df679377666575d08dead17443d3
https://doi.org/10.1158/1078-0432.22451574

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Supplementary Figure 4 from EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors

PDF file - 240K, Dose-dependent inhibition of c-Met auto-phosphorylation in vivo. Panel A: Mice bearing established tumors, derived from s.c. injection of Hs746T gastric cancer cells, received a single dose of 3 mg/kg , 10 mg/kg , 30 mg/kg , and 100

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a08877cd5caaa8f4efb72687d103de0
https://doi.org/10.1158/1078-0432.22451565

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