Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Bettina Bundgaard"'
Autor:
Emil Kofod-Olsen, Janni M L Møller, Mariane H Schleimann, Bettina Bundgaard, Rasmus O Bak, Bodil Øster, Jacob G Mikkelsen, Ted Hupp, Per Höllsberg
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59223 (2013)
Infection with human herpesvirus (HHV)-6B alters cell cycle progression and stabilizes tumor suppressor protein p53. In this study, we have analyzed the activity of p53 after stimulation with p53-dependent and -independent DNA damaging agents during
Externí odkaz:
https://doaj.org/article/47cab761a6914845b4a9830b3b2071cd
Publikováno v:
Clinical and Developmental Immunology, Vol 2013 (2013)
Human dendritic cells (DC) can be differentiated from blood monocytes in the presence of GM-CSF and IL-4 and matured by lipopolysaccharide (LPS). Vitamin D3 inhibits the maturation of human DC measured by changes in surface expression of HLA-DR, CD14
Externí odkaz:
https://doaj.org/article/fc2a35774f1e4af2a537249b5ec5a3d2
Autor:
Vivien R. Schack, Morten K. Herlin, Henrik Pedersen, J. Magnus Bernth Jensen, Mia Færch, Bettina Bundgaard, Rasmus K. Jensen, Uffe B. Jensen, Rikke Christensen, Gregers R. Andersen, Steffen Thiel, Per Höllsberg
Publikováno v:
Schack, V R, Herlin, M K, Pedersen, H, Jensen, J M B, Faerch, M, Bundgaard, B, Jensen, R K, Jensen, U B, Christensen, R, Andersen, G R, Thiel, S & Höllsberg, P 2022, ' Novel homozygous CD46 variant with C-isoform expression affects C3b inactivation in atypical hemolytic uremic syndrome ', European Journal of Immunology, vol. 52, no. 10, pp. 1610-1619 . https://doi.org/10.1002/eji.202249838
Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy that may lead to organ failure. Dysregulation of the complement system can cause aHUS, and various disease-related variants in the complement regulatory protein CD46 are descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0955c70b7024967005b4f960aee77931
https://doi.org/10.1002/eji.202249838
https://doi.org/10.1002/eji.202249838
Autor:
Litten Sørensen Rossen, Vivien R. Schack, Katrine Kyd Holstein Thuesen, Bettina Bundgaard, Per Höllsberg
Publikováno v:
Rossen, L S, Schack, V, Thuesen, K K H, Bundgaard, B & Höllsberg, P B 2022, ' CD46 isoforms influence the mode of entry by human herpesvirus 6A/B in T cells ', Journal of Virology, vol. 96, no. 5, e01557-21 . https://doi.org/10.1128/jvi.01557-21
J Virol
J Virol
CD46 is a receptor for human herpesvirus 6A (HHV-6A) and is in some cells also important for infection with HHV-6B. CD46 has several isoforms of which the most commonly expressed can be distinguished by expression of a BC domain or a C domain in a se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3966b08fe96e395a470ce34a033d7d
https://pure.au.dk/portal/da/publications/cd46-isoforms-influence-the-mode-of-entry-by-human-herpesvirus-6ab-in-t-cells(102c02cd-18c3-48bd-bd66-b48151c5353b).html
https://pure.au.dk/portal/da/publications/cd46-isoforms-influence-the-mode-of-entry-by-human-herpesvirus-6ab-in-t-cells(102c02cd-18c3-48bd-bd66-b48151c5353b).html
Autor:
Anja Bille Bohn, Bjarne Kuno Møller, Per Höllsberg, Aida S. Hansen, Bettina Bundgaard, Mette Biltoft
Publikováno v:
Hansen, A S, Biltoft, M, Bundgaard, B, Bohn, A B, Møller, B K & Höllsberg, P B 2019, ' CD46 activation induces distinct CXCL-10 response in monocytes and monocyte-derived dendritic cells ', Cytokine, vol. 113, pp. 466-469 . https://doi.org/10.1016/j.cyto.2018.06.030
CD46 is an important immune regulatory receptor with dual functions, however, the CD46 isoform distribution and the effect of CD46 activation on the cytokine production in monocytes and monocyte-derived dendritic cells (moDCs) is unclear. Here, we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11618282790d3f75fd787490b03f241
https://pure.au.dk/portal/da/publications/cd46-activation-induces-distinct-cxcl10-response-in-monocytes-and-monocytederived-dendritic-cells(01dbebaf-4990-4614-8cdc-39eaa2525373).html
https://pure.au.dk/portal/da/publications/cd46-activation-induces-distinct-cxcl10-response-in-monocytes-and-monocytederived-dendritic-cells(01dbebaf-4990-4614-8cdc-39eaa2525373).html
Autor:
Bettina Bundgaard, Per Höllsberg, Mette Biltoft, Bjarne Kuno Møller, Josefine Slater, Aida S. Hansen
Publikováno v:
Immunology Letters
Hansen, A S, Slater, J, Biltoft, M, Bundgaard, B B, Møller, B K & Höllsberg, P 2018, ' CD46 is a potent co-stimulatory receptor for expansion of human IFN-γ-producing CD8+ T cells ', Immunology Letters, vol. 200, pp. 26-32 . https://doi.org/10.1016/j.imlet.2018.06.003
Hansen, A S, Slater, J, Biltoft, M, Bundgaard, B B, Møller, B K & Höllsberg, P 2018, ' CD46 is a potent co-stimulatory receptor for expansion of human IFN-γ-producing CD8+ T cells ', Immunology Letters, vol. 200, pp. 26-32 . https://doi.org/10.1016/j.imlet.2018.06.003
Highlights • Activation of CD46 induces rapid down-modulation of CD46 expression on the surface of CD8+ T cells. • CD46 co-stimulation potently induces CD8+ T cell proliferation. • CD46 co-stimulation does not induce a switch to IL-10 productio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bcab20691da84aa1d6d0a5ac3c8123e
https://pubmed.ncbi.nlm.nih.gov/29902483
https://pubmed.ncbi.nlm.nih.gov/29902483
Autor:
Per Höllsberg, Anders Dige, Lasse Bjerg, Anne Brosbøl-Ravnborg, Caroline W. Tørring, Bettina Bundgaard, Thor Petersen
Publikováno v:
Bjerg, L, Brosbøl-Ravnborg, A, Tørring, C W, Dige, A K, Bundgaard, B, Petersen, T & Höllsberg, P 2012, ' Altered frequency of T regulatory cells is associated with disability status in relapsing-remitting multiple sclerosis patients ', Journal of Neuroimmunology, vol. 249, pp. 76-82 .
Aarhus University
Aarhus University
A perturbed immunoregulation may be part of the pathogenesis of relapsing–remitting multiple sclerosis (RRMS). In this study, we demonstrate a dichotomy within the frequency of Treg among newly diagnosed RRMS patients but not in healthy controls. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9fd79c1e576f113875d19a89e0a68e
https://doi.org/10.1016/j.jneuroim.2012.04.012
https://doi.org/10.1016/j.jneuroim.2012.04.012
Publikováno v:
Øster, B, Kaspersen, M D, Kofod-Olsen, E, Bundgaard, B & Höllsberg, P 2006, ' Human herpesvirus 6B inhibits cell proliferation by a p53-independent pathway ', Journal of Clinical Virology, vol. Suppl. 1, pp. S63-S68 .
Background Various forms of cellular stress can activate the tumour suppressor protein p53, an important regulator of cell cycle arrest, apoptosis, and cellular senescence. Cells infected by human herpesvirus 6B (HHV-6B) accumulate aberrant amounts o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8605e04be58db990a28078cc118a53f
https://doi.org/10.1016/s1386-6532(06)70014-2
https://doi.org/10.1016/s1386-6532(06)70014-2
Autor:
Emil Kofod-Olsen, Katrine Ross-Hansen, Mariane Høgsbjerg Schleimann, Dea Kejlberg Jensen, Janni Michelle Møller, Bettina Bundgaard, Jacob Giehm Mikkelsen, Per Höllsberg
Publikováno v:
Kofod-Olsen, E, Ross-Hansen, K, Schleimann, M H, Jensen, D K, Møller, J M, Bundgaard, B, Mikkelsen, J G & Höllsberg, P 2012, ' U20 is responsible for human herpesvirus 6B inhibition of TNF receptor-dependent signaling and apoptosis ', Journal of Virology, vol. 86, pp. 11483-92 .
Aarhus University
Aarhus University
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::a9a3662206921ff43a407a1a275fbcfe
https://pure.au.dk/portal/da/publications/u20-is-responsible-for-human-herpesvirus-6b-inhibition-of-tnf-receptordependent-signaling-and-apoptosis(b2d86e4a-285f-4e6d-9520-adc7f0668441).html
https://pure.au.dk/portal/da/publications/u20-is-responsible-for-human-herpesvirus-6b-inhibition-of-tnf-receptordependent-signaling-and-apoptosis(b2d86e4a-285f-4e6d-9520-adc7f0668441).html
Autor:
Carolyn Buckner, Bodil Øster, Jennifer Fraser, Pedro A. Lazo, Nicola J. MacLaine, David W. Meek, Bettina Bundgaard, Per Höllsberg, Tedd R Hupp
Publikováno v:
Maclaine, NJ, Øster, B, Bundgaard, B, Fraser, JA, Buckner, C, Lazo, PA, Meek, DW, Höllsberg, P & Hupp, TR 2008, ' A central role for CK1 in catalysing phosphorylation of the P53 transactivation domain at serine 20 after HHV-6B viral infection. ', Journal of Biological Chemistry, vol. 283, pp. 28563-73 .
MacLaine, N J, Oster, B, Bundgaard, B, Fraser, J A, Buckner, C, Lazo, P A, Meek, D W, Hoellsberg, P & Hupp, T R 2008, ' A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection ', Journal of Biological Chemistry, vol. 283, no. 42, pp. 28563-28573 . https://doi.org/10.1074/jbc.M804433200
MacLaine, N J, Oster, B, Bundgaard, B, Fraser, J A, Buckner, C, Lazo, P A, Meek, D W, Hoellsberg, P & Hupp, T R 2008, ' A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection ', Journal of Biological Chemistry, vol. 283, no. 42, pp. 28563-28573 . https://doi.org/10.1074/jbc.M804433200
The tumor suppressor protein p53 is activated by distinct cellular stresses including radiation, hypoxia, type I interferon, and DNA/RNA virus infection. The transactivation domain of p53 contains a phosphorylation site at Ser(20) whose modification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4515578fdd7631995b323e36642c28
https://europepmc.org/articles/PMC2661408/
https://europepmc.org/articles/PMC2661408/