Výsledky vyhledávání

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Akademický článek

CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases.

Autor: Bettayeb, K¹, Oumata, N², Echalier, A³, Ferandin, Y¹, Endicott, J A³, Galons, H² herve.galons@univ-paris5.fr, Meijer, L¹ meijer@sb-roscoff.fr

Publikováno v: Oncogene. 10/2/2008, Vol. 27 Issue 44, p5797-5807. 11p. 3 Black and White Photographs, 2 Diagrams, 3 Charts, 2 Graphs.

Zobrazit plný text záznamu

Akademický článek

7-Bromoindirubin-3′-oxime induces caspase-independent cell death.

Autor: Ribas, J.¹ meijer@sb-roscoff.fr, Bettayeb, K.¹, Ferandin, Y.¹, Knockaert, M.¹, Garrofé-Ochoa, X.², Totzke, F.³, Schächtele, C.³, Mester, J.⁴, Polychronopoulos, P.⁵, Magiatis, P.⁵, Skaltsounis, A.-L.⁵, Boix, J.², Meijer, L.¹ meijer@sb-roscoff.fr

Publikováno v: Oncogene. 10/12/2006, Vol. 25 Issue 47, p6304-6318. 15p. 1 Color Photograph, 2 Charts, 11 Graphs.

Zobrazit plný text záznamu

Soluble 3′,6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period

Autor: Vougogiannopoulou, K. Ferandin, Y. Bettayeb, K. Myrianthopoulos, V. Lozach, O. Fan, Y. Johnson, C.H. Magiatis, P. Skaltsounis, A.-L. Mikros, E. Meijer, L.

Glycogen synthase kinase -3 (GSK-3) is a key enzyme involved in numerous physiological events and in major diseases, such as Alzheimer's disease, diabetes, and cardiac hypertrophy. Indirubins are bis-indoles that can be generated from various natural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::fd7961548bffe6d8509740251ef679cc
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3062288

Zobrazit plný text záznamu

Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1

Autor: Oumata, N. Bettayeb, K. Ferandin, Y. Demange, L. Lopez-Giral, A. Goddard, M.-L. Myrianthopoulos, V. Mikros, E. Flajolet, M. Greengard, P. Meijer, L. Galons, H.

Cyclin-dependent kinases (CDKs) and casein kinases 1 (CK1) are involved in the two key molecular features of Alzheimer's disease, production of amyloid-β peptides (extracellular plaques) and hyper-phosphorylation of Tau (intracellular neurofibrillar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::e934b694d93b677a6dc9c15edd7e6911
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3062308

Zobrazit plný text záznamu

Photoreactivity of indirubin derivatives

Autor: Olivier, D. Poincelot, M.-A. Douillard, S. Lefevre, C. Moureau, J. Ferandin, Y. Bettayeb, K. Xiao, Z. Magiatis, P. Skaltsounis, L. Meijer, L. Patrice, T.

Twenty-nine analogs of indirubin, an isomer of indigo, have been synthesized to optimize its promising kinase inhibitory scaffold. These compounds being also pigmented, have been tested for their photoreactivity. Absorption maxima were between 485 nm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::7e10051fb457d8f3d6031441160016e5
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3067660

Zobrazit plný text záznamu

Meriolins, a new class of cell death-inducing kinase inhibitors with enhanced selectivity for cyclin-dependent kinases

Autor: Bettayeb K, Tirado OM, Marionneau-Lambot S, Ferandin Y, Lozach O, Morris JC, Mateo-Lozano S, Drueckes P, Schächtele C, Kubbutat MH, Liger F, Marquet B, Joseph B, Echalier A, Endicott JA, Notario V, Meijer L

Publikováno v: CANCER RESEARCH
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu

Protein kinases represent promising anticancer drug targets. We describe here the meriolins, a new family of inhibitors of cyclin-dependent kinases (CDK). Meriolins represent a chemical structural hybrid between meridianins and variolins, two familie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::5095b5de325aac5b8694f5ce96c358df
http://fundanet.fsjd.org/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=11151

Zobrazit plný text záznamu

3′-substituted 7-halogenoindirubins, a new class of cell death inducing agents

Autor: Ferandin, Y. Bettayeb, K. Kritsanida, M. Lozach, O. Polychronopoulos, P. Magiatis, P. Skaltsounis, A.-L. Meijer, L.

Indirubins are kinase inhibitory bis-indoles that can be generated from various plant, mollusk, mammalian, and bacterial sources or chemically synthesized. We here report on the synthesis and biological evaluation of 3′-substituted 7-halogenoindiru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::17ac272f9fbb4148825ff034241d06f9
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3062804

Zobrazit plný text záznamu

7-Bromoindirubin-3′-oxime induces caspase-independent cell death

Autor: Ribas, J. Bettayeb, K. Ferandin, Y. Knockaert, M. Garrofé-Ochoa, X. Totzke, F. Schächtele, C. Mester, J. Polychronopoulos, P. Magiatis, P. Skaltsounis, A.-L. Boix, J. Meijer, L.

Indirubin, an isomer of indigo, is a reported inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase-3 (GSK-3) as well as an agonist of the aryl hydrocarbon receptor (AhR). Indirubin is the active ingredient of a traditional Chines

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::dc256ee18dbfa6e50684989bbdfd09e7
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3094613

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Vyhledávací nástroje:

Upřesnit hledání