CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases.

Autor: Bettayeb, K¹, Oumata, N², Echalier, A³, Ferandin, Y¹, Endicott, J A³, Galons, H² herve.galons@univ-paris5.fr, Meijer, L¹ meijer@sb-roscoff.fr

Publikováno v: Oncogene. 10/2/2008, Vol. 27 Issue 44, p5797-5807. 11p. 3 Black and White Photographs, 2 Diagrams, 3 Charts, 2 Graphs.

GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease.

Autor: Xu P; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY., Chang JC; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY.; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY., Zhou X; Division of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science and Technology Parks, Hong Kong, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease, and Drug Development, Shenzhen-Hong Kong Institute of Brain Science, HKUST Shenzhen Research Institute, Shenzhen, Guangdong, China., Wang W; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY., Bamkole M; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY., Wong E; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY., Bettayeb K; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY., Jiang LL; Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA., Huang T; Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA., Luo W; Brain and Mind Research Institute, Weill Cornell Medical College, New York, NY., Xu H; Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA., Nairn AC; Department of Psychiatry, Yale School of Medicine, Connecticut Mental Health Center, New Haven, CT., Flajolet M; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY., Ip NY; Division of Life Science, State Key Laboratory of Molecular Neuroscience and Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong, China.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong Science and Technology Parks, Hong Kong, China.; Guangdong Provincial Key Laboratory of Brain Science, Disease, and Drug Development, Shenzhen-Hong Kong Institute of Brain Science, HKUST Shenzhen Research Institute, Shenzhen, Guangdong, China., Li YM; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY.; Program of Pharmacology and Neurosciences, Weill Graduate School of Medical Sciences of Cornell University, New York, NY., Greengard P; Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY.

Publikováno v: The Journal of experimental medicine [J Exp Med] 2021 Aug 02; Vol. 218 (8). Date of Electronic Publication: 2021 Jun 22.

Stretching the structural envelope of imatinib to reduce β-amyloid production by modulating both β- and γ-secretase cleavages of APP.

Autor: Netzer, William J.¹ billnetzer@gmail.com, Sinha, Anjana¹ sinhaanjana5819@gmail.com, Ghias, Mondana¹, Chang, Emily¹, Gindinova, Katherina¹, Mui, Emily¹, Seo, Ji-Seon¹, Sinha, Subhash C.^1,2 sus2044@med.cornell.edu, Uliassi, Elisa³, Niu, Yan⁴

Publikováno v: Frontiers in Chemistry. 2024, p1-40. 40p.

Soluble 3′,6-substituted indirubins with enhanced selectivity toward glycogen synthase kinase -3 alter circadian period

Autor: Vougogiannopoulou, K. Ferandin, Y. Bettayeb, K. Myrianthopoulos, V. Lozach, O. Fan, Y. Johnson, C.H. Magiatis, P. Skaltsounis, A.-L. Mikros, E. Meijer, L.

Glycogen synthase kinase -3 (GSK-3) is a key enzyme involved in numerous physiological events and in major diseases, such as Alzheimer's disease, diabetes, and cardiac hypertrophy. Indirubins are bis-indoles that can be generated from various natural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::fd7961548bffe6d8509740251ef679cc
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3062288

Photoreactivity of indirubin derivatives

Autor: Olivier, D. Poincelot, M.-A. Douillard, S. Lefevre, C. Moureau, J. Ferandin, Y. Bettayeb, K. Xiao, Z. Magiatis, P. Skaltsounis, L. Meijer, L. Patrice, T.

Twenty-nine analogs of indirubin, an isomer of indigo, have been synthesized to optimize its promising kinase inhibitory scaffold. These compounds being also pigmented, have been tested for their photoreactivity. Absorption maxima were between 485 nm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::7e10051fb457d8f3d6031441160016e5
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3067660