Výsledky vyhledávání - "Bett Kimutai"

Amino acid-linked platinum(II) compounds: non-canonical nucleoside preferences and influence on glycosidic bond stabilities

Autor: Jun Jiang, M. T. Rodgers, C. C. He, Xun Bao, Christine S. Chow, Bett Kimutai, Andrew Roberts, Marcel L Jones, Zhihua Yang

Publikováno v: Journal of Biological Inorganic Chemistry

Nucleobases serve as ideal targets where drugs bind and exert their anticancer activities. Cisplatin (cisPt) preferentially coordinates to 2′-deoxyguanosine (dGuo) residues within DNA. The dGuo adducts that are formed alter the DNA structure, contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55828866ab7856d405297f6ea15d8ae3
https://doi.org/10.1007/s00775-019-01693-y

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Structural determination of arginine-linked cisplatin complexes via IRMPD action spectroscopy: arginine binds to platinum via NO- binding mode

Autor: C. C. He, Zachary J. Devereaux, Nathan A. Cunningham, Christine S. Chow, Jos Oomens, Jonathan Martens, L. A. Hamlow, Giel Berden, Bett Kimutai, M. T. Rodgers, H. A. Roy

Publikováno v: PCCP Physical Chemistry Chemical Physics, 23, 21959-21971
PCCP Physical Chemistry Chemical Physics, 23, 38, pp. 21959-21971

Cisplatin, (NH3)2PtCl2, has been known as a successful metal-based anticancer drug for more than half a century. Its analogue, Argplatin, arginine-linked cisplatin, (Arg)PtCl2, is being investigated because it exhibits reactivity towards DNA and RNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526272662390680413bb523969fff267
https://doi.org/10.1039/d1cp03407c

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STRUCTURE DETERMINATION OF ORNITHINE-LINKED CISPLATIN BY INFRARED MULTIPLE PHOTON DISSOCIATION ACTION SPECTROSCOPY

Autor: Vincent Steinmetz, J. Gao, Christopher P. McNary, P. B. Armentrout, Bett Kimutai, Christine S. Chow, M. T. Rodgers, Jos Oomens, L. A. Hamlow, Giel Berden, Y-W Nei, C. C. He, Philippe Maître, Xun Bao, Jonathan Martens, H. A. Roy

Publikováno v: Proceedings of the 71st International Symposium on Molecular Spectroscopy.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61ced162fe40e7b54cb7443da6361d52
https://doi.org/10.15278/isms.2016.wd06

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STRUCTURE DETERMINATION OF CISPLATIN-AMINO ACID ANALOGUES BY INFRARED MULTIPLE PHOTON DISSOCIATION ACTION SPECTROSCOPY

Autor: Bett Kimutai, Yanlong Zhu, Y-W Nei, M. T. Rodgers, Stephen Strobehn, J. Gao, C. C. He, Xun Bao, Jos Oomens, Christine S. Chow

Publikováno v: Proceedings of the 70th International Symposium on Molecular Spectroscopy.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d290b348715f232639908f5fef83a0fc
https://doi.org/10.15278/isms.2015.mi12

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Evaluation of Hybrid Theoretical Approaches for Structural Determination of a Glycine-Linked Cisplatin Derivative via Infrared Multiple Photon Dissociation (IRMPD) Action Spectroscopy

Autor: S. F. Strobehn, Yanlong Zhu, J. Gao, Jos Oomens, Bett Kimutai, Giel Berden, M. T. Rodgers, Christine S. Chow, L. A. Hamlow, C. C. He, Xun Bao

Publikováno v: The Journal of Physical Chemistry A, 119, 10980-10987
The Journal of Physical Chemistry. A, 119(44), 10980-10987. American Chemical Society
The Journal of Physical Chemistry A, 119, 44, pp. 10980-10987

To gain a better understanding of the binding mechanism and assist in the optimization of chemical probing and drug design applications, experimental and theoretical studies of a series of amino acid-linked cisplatin derivatives are being pursued. Gl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc1f8aa427952be238f9f18c56f1ad5
https://doi.org/10.1021/acs.jpca.5b08181

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