Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Betsy R. Schulman"'
Autor:
Jun-Hui Yuan, Betsy R. Schulman, Philip R. Effraim, Dib-Hajj Sulayman, Deborah S. Jacobs, Stephen G. Waxman
Publikováno v:
PAIN Reports, Vol 5, Iss 4, p e826 (2020)
Abstract. Background:. Refractive surgery, specifically laser-assisted in situ keratomileusis and photorefractive keratectomy, are widely applied procedures to treat myopia, hyperopia, and astigmatism. After surgery, a subgroup of cases suffers from
Externí odkaz:
https://doaj.org/article/cb2d80f0e18e403fb8ef5e083e6a9140
Publikováno v:
Neurobiology of Pain, Vol 3, Iss , Pp 8-14 (2018)
Inherited erythromelalgia (IEM) is a chronic pain disorder caused by gain-of-function mutations of peripheral sodium channel Nav1.7, in which warmth triggers severe pain. Little is known about the brain representation of pain in IEM. Here we study tw
Externí odkaz:
https://doaj.org/article/fe4fb9d9ae5d45af9a502f113dbc5fcb
Autor:
Mohammad-Reza Ghovanloo, Philip R. Effraim, Jun-Hui Yuan, Betsy R. Schulman, Deborah S. Jacobs, Sulayman D. Dib-Hajj, Stephen G. Waxman
Publikováno v:
Journal of Neurophysiology. 129:609-618
Mechanisms underlying pain after axonal injury remain elusive. A small subgroup of patients experience pain after corneal refractive surgery, providing a human pain model after well-defined injury to axons. Here we analyze a mutation (P610T) in Nav1.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbd1266046e7bf30f834d811dc9dc5b6
https://doi.org/10.1152/jn.00457.2022
https://doi.org/10.1152/jn.00457.2022
Autor:
Mark Estacion, Lubin Chen, Malgorzata A. Mis, Shujun Liu, Betsy R. Schulman, Brian S. Tanaka, Jun-Hui Yuan, Sulayman D. Dib-Hajj, Stephen G. Waxman, Fadia B. Dib-Hajj
Publikováno v:
Brain Communications
There is a pressing need for understanding of factors that confer resilience to pain. Gain-of-function mutations in sodium channel Nav1.7 produce hyperexcitability of dorsal root ganglion neurons underlying inherited erythromelalgia, a human genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f8705f031a996fe9cdc74e51d73e06
http://europepmc.org/articles/PMC8454204
http://europepmc.org/articles/PMC8454204
Publikováno v:
Neurobiology of pain (Cambridge, Mass.)
Neurobiology of Pain, Vol 3, Iss, Pp 8-14 (2018)
Neurobiology of Pain, Vol 3, Iss, Pp 8-14 (2018)
Inherited erythromelalgia (IEM) is a chronic pain disorder caused by gain-of-function mutations of peripheral sodium channel Nav1.7, in which warmth triggers severe pain. Little is known about the brain representation of pain in IEM. Here we study tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85a32f2ca15e7403da2d0ec6d6a43b3
https://pubmed.ncbi.nlm.nih.gov/31080911
https://pubmed.ncbi.nlm.nih.gov/31080911
Autor:
Yang Yang, Rolando Garcia-Milian, Brian S. Tanaka, Sulayman D. Dib-Hajj, Malgorzata A. Mis, Talia Adi, Carolina Gomis-Perez, Shujun Liu, Stephen G. Waxman, Fadia B. Dib-Hajj, Betsy R. Schulman
Pain is a complex process that involves both detection in the peripheral nervous system and perception in the CNS. Individual-to-individual differences in pain are well documented, but not well understood. Here we capitalized on inherited erythromela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::668fbb95490d7501ba4ac7b3b6bb43af
https://europepmc.org/articles/PMC6335750/
https://europepmc.org/articles/PMC6335750/
Autor:
Yang Yang, Sulayman D. Dib-Hajj, Lawrence J. Macala, Mark Estacion, Daniel B. Horton, Palak Shah, Stephen G. Waxman, Betsy R. Schulman, Malgorzata A. Mis, Jianying Huang
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 36(28)
Voltage-gated sodium channel Nav1.7 is a central player in human pain. Mutations in Nav1.7 produce several pain syndromes, including inherited erythromelalgia (IEM), a disorder in which gain-of-function mutations render dorsal root ganglia (DRG) neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f4a952b1ae33c2e46a497dab0d20132
https://pubmed.ncbi.nlm.nih.gov/27413160
https://pubmed.ncbi.nlm.nih.gov/27413160
Autor:
Betsy R. Schulman, Stephen G. Waxman, Talia Adi, Sulayman D. Dib-Hajj, Steven Vernino, Mark Estacion
Publikováno v:
Molecular Pain
Voltage-gated sodium channel Nav1.7 is a threshold channel in peripheral dorsal root ganglion (DRG), trigeminal ganglion, and sympathetic ganglion neurons. Gain-of-function mutations in Nav1.7 have been shown to increase excitability in DRG neurons a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e47ea528b8df33829548a0f9ef027ba
https://doi.org/10.1177/1744806918815007
https://doi.org/10.1177/1744806918815007
Autor:
Jan Vollert, Aoibhinn McDonnell, Sulayman D. Dib-Hajj, Fiona Brock, Sonia Cobain, Zahid Ali, Sanela Tarabar, Stephen G. Waxman, Tina Mainka, Betsy R. Schulman
Publikováno v:
Brain : a journal of neurology. 139(Pt 4)
Inherited erythromelalgia, the first human pain syndrome linked to voltage-gated sodium channels, is widely regarded as a genetic model of human pain. Because inherited erythromelalgia was linked to gain-of-function changes of sodium channel Nav1.7 o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d081afb45c06d67d6f66517cb4b65a1f
https://pubmed.ncbi.nlm.nih.gov/26920677
https://pubmed.ncbi.nlm.nih.gov/26920677
Publikováno v:
Developmental Dynamics. 234:1046-1054
In C. elegans, heterochronic genes control the timing of cell fate determination during development. Two heterochronic genes, let-7 and lin-4, encode microRNAs (miRNAs) that down-regulate a third heterochronic gene lin-41 by binding to complementary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a057a1993fd992a2e3043539d4525e7
https://doi.org/10.1002/dvdy.20599
https://doi.org/10.1002/dvdy.20599