Four cases of myocarditis in US hospitals possibly associated with clozapine poor metabolism and a comparison with prior published cases

Autor: Michael, Koenig, Betsy, McCollum, Julie K, Spivey, Jerry K, Coleman, Charles, Shelton, Robert O, Cotes, David R, Goldsmith, Jose, De Leon

Publikováno v: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. 24(1)

Objectives: Clozapine-induced myocarditis may be a hypersensitivity reaction due to titration that was too rapid for a patient's clozapine metabolism. Obesity, infections, and inhibitors (e.g., valproate) may lead to clozapine poor metabolizer (PM) s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::24d7f85d0ef67143327c96d48a83ab29
https://pubmed.ncbi.nlm.nih.gov/35451590

An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels

Autor: Jose de Leon, Georgios Schoretsanitis, Robert L. Smith, Espen Molden, Anssi Solismaa, Niko Seppälä, Miloslav Kopeček, Patrik Švancer, Ismael Olmos, Carina Ricciardi, Celso Iglesias-Garcia, Ana Iglesias-Alonso, Edoardo Spina, Can-Jun Ruan, Chuan-Yue Wang, Gang Wang, Yi-Lang Tang, Shih-Ku Lin, Hsien-Yuan Lane, Yong Sik Kim, Se Hyun Kim, Anto P. Rajkumar, Dinora F. González-Esquivel, Helgi Jung-Cook, Trino Baptista, Christopher Rohde, Jimmi Nielsen, Hélène Verdoux, Clelia Quiles, Emilio J. Sanz, Carlos De Las Cuevas, Dan Cohen, Peter F.J. Schulte, Aygün Ertuğrul, A. Elif Anıl Yağcıoğlu, Nitin Chopra, Betsy McCollum, Charles Shelton, Robert O. Cotes, Arun R. Kaithi, John M. Kane, Saeed Farooq, Chee H. Ng, John Bilbily, Christoph Hiemke, Carlos López-Jaramillo, Ian McGrane, Fernando Lana, Chin B. Eap, Manuel Arrojo-Romero, Flavian Ş. Rădulescu, Erich Seifritz, Susanna Every-Palmer, Chad A. Bousman, Emmanuel Bebawi, Rahul Bhattacharya, Deanna L. Kelly, Yuji Otsuka, Judit Lazary, Rafael Torres, Agustin Yecora, Mariano Motuca, Sherry K.W. Chan, Monica Zolezzi, Sami Ouanes, Domenico De Berardis, Sandeep Grover, Ric M. Procyshyn, Richard A. Adebayo, Oleg O. Kirilochev, Andrey Soloviev, Konstantinos N. Fountoulakis, Alina Wilkowska, Wiesław J. Cubała, Muhammad Ayub, Alzira Silva, Raphael M. Bonelli, José M. Villagrán-Moreno, Benedicto Crespo-Facorro, Henk Temmingh, Eric Decloedt, Maria R. Pedro, Hiroyoshi Takeuchi, Masaru Tsukahara, Gerhard Gründer, Marina Sagud, Andreja Celofiga, Dragana Ignjatovic Ristic, Bruno B. Ortiz, Helio Elkis, António J. Pacheco Palha, Adrián LLerena, Emilio Fernandez-Egea, Dan Siskind, Abraham Weizman, Rim Masmoudi, Shamin Mohd Saffian, Jonathan G. Leung, Peter F. Buckley, Stephen R. Marder, Leslie Citrome, Oliver Freudenreich, Christoph U. Correll, Daniel J. Müller

Publikováno v: De Leon, J, Schoretsanitis, G, Smith, R L, Molden, E, Solismaa, A, Seppälä, N, Kopeček, M, Švancer, P, Olmos, I, Ricciardi, C, Iglesias-Garcia, C, Iglesias-Alonso, A, Spina, E, Ruan, C J, Wang, C Y, Wang, G, Tang, Y L, Lin, S K, Lane, H Y, Kim, Y S, Kim, S H, Rajkumar, A P, González-Esquivel, D F, Jung-Cook, H, Baptista, T, Rohde, C, Nielsen, J, Verdoux, H, Quiles, C, Sanz, E J, De Las Cuevas, C, Cohen, D, Schulte, P F J, Ertuǧrul, A, Anll Yaǧcloǧlu, A E, Chopra, N, McCollum, B, Shelton, C, Cotes, R O, Kaithi, A R, Kane, J M, Farooq, S, Ng, C H, Bilbily, J, Hiemke, C, López-Jaramillo, C, McGrane, I, Lana, F, Eap, C B, Arrojo-Romero, M, Rǎdulescu, F, Seifritz, E, Every-Palmer, S, Bousman, C A, Bebawi, E, Bhattacharya, R, Kelly, D L, Otsuka, Y, Lazary, J, Torres, R, Yecora, A, Motuca, M, Chan, S K W, Zolezzi, M, Ouanes, S, De Berardis, D, Grover, S, Procyshyn, R M, Adebayo, R A, Kirilochev, O O, Soloviev, A, Fountoulakis, K N, Wilkowska, A, Cubała, W J, Ayub, M, Silva, A, Bonelli, R M, Villagrán-Moreno, J M, Crespo-Facorro, B, Temmingh, H, Decloedt, E, Pedro, M R, Takeuchi, H, Tsukahara, M, Gründer, G, Sagud, M, Celofiga, A, Ignjatovic Ristic, D, Ortiz, B B, Elkis, H, Pacheco Palha, A J, Llerena, A, Fernandez-Egea, E, Siskind, D, Weizman, A, Masmoudi, R, Mohd Saffian, S, Leung, J G, Buckley, P F, Marder, S R, Citrome, L, Freudenreich, O, Correll, C U & Müller, D J 2022, ' An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels ', Pharmacopsychiatry, vol. 55, no. 2, pp. 73-86 . https://doi.org/10.1055/a-1625-6388

This international guideline proposes improving clozapine package inserts worldwide by using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest that clozapine is the third most toxic drug in the United States (US), and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c69e293db54415a8bfeda3a4a06ea2f
http://hdl.handle.net/20.500.12278/124424

Proactive Modification to Clozapine Dose in a Patient With Pneumonia to Prevent Toxicity

Autor: Charles I. Shelton, Betsy McCollum, Paige K. Juettner

Publikováno v: The Primary Care Companion For CNS Disorders. 23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f480a2293b924f48dbdabb25741cca
https://doi.org/10.4088/pcc.20l02622

High Doses of Drugs Extensively Metabolized by CYP3A4 Were Needed to Reach Therapeutic Concentrations in Two Patients Taking Inducers

Autor: Betsy McCollum, Nitin Chopra, Judy Ognibene, Jose de Leon, Charles I. Shelton, Can-Jun Ruan

Publikováno v: Revista Colombiana de Psiquiatría, Volume: 49, Issue: 2, Pages: 84-95, Published: 18 JUN 2020

Introduction: In the last 20 years of clinical practice, the senior author has identified these 2 rare cases in which the patients needed extremely high doses of drugs metabolized by CYP3A4 to reach and maintain serum therapeutic concentrations. Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142c50975b212ae78a973ea5ae559396
https://pubmed.ncbi.nlm.nih.gov/32446424

A Case Report That Suggested That the Patient Was Very Sensitive to Induction and Needed 1600 mg/d of Lamotrigine to Get Therapeutic Concentrations

Autor: Amy O’Neill, Jose de Leon, James Jackson, Betsy McCollum

Publikováno v: Journal of Clinical Psychopharmacology. 35:745-747

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e65aa46a377f198c9bd177ed40ca6ab
https://doi.org/10.1097/jcp.0000000000000401