Expression and function of Kv1.3 channel in malignant T cells in Sézary syndrome

Autor: Thorbjørn Krejsgaard, Niels Ødum, Mads Hald Andersen, Veronica Stolearenco, Özcan Met, David L. Petersen, Pieter Spee, Terkild B. Buus, Andreas Willerslev-Olsen, Thomas Litman, Per thor Straten, Tengpeng Hu, Simon Fredholm, Lise Mette Rahbek Gjerdrum, Anders Woetmann, Edda Blümel, Anneline Nansen, Hanne Fogh, Maria Gluud, Robert Gniadecki, Betina Kerstin Lundholt, Claudia Nastasi, Madalena N Monteiro

Publikováno v: Oncotarget
Hu, T, Buus, T B, Krejsgaard, T, Nansen, A, Lundholt, B K, Spee, P, Fredholm, S, Petersen, D L, Blümel, E, Gluud, M, Monteiro, M N, Willerslev-Olsen, A, Andersen, M H, Straten, P T, Met, Ö, Stolearenco, V, Fogh, H, Gniadecki, R, Nastasi, C, Litman, T, Woetmann, A, Gjerdrum, L M R & Ødum, N 2019, ' Expression and function of Kv1.3 channel in malignant T cells in Sézary syndrome ', OncoTarget, vol. 10, no. 47, pp. 4894-4906 . https://doi.org/10.18632/oncotarget.27122

The voltage-gated potassium channel Kv1.3 (KCNA3) is expressed by a subset of chronically activated memory T cells and plays an important role in their activation and proliferation. Here, we show that primary malignant T cells isolated from patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963263f835fea8037212a6bd57ee4f1e
http://europepmc.org/articles/PMC6690676

Technical Notes: A Simple Technique for Reducing Edge Effect in Cell-Based Assays

Autor: Len Pagliaro, Kurt M. Scudder, Betina Kerstin Lundholt

Publikováno v: SLAS Discovery. 8:566-570

Several factors are known to increase the noise and variability of cell-based assays used for high-throughput screening. In particular, edge effects can result in an unacceptably high plate rejection rate in screening runs. In an effort to minimize t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::68c9af4492fb10482f6f60609068890e
https://doi.org/10.1177/1087057103256465

Identification of RAS-mitogen-activated protein kinase signaling pathway modulators in an ERF1 redistribution screen

Autor: Charlotta Grånäs, Morten Praestegaard, Viggo Linde, Søren Jensby Nielsen, Frosty Loechel, Betina Kerstin Lundholt, Sara Petersen Bjørn, Eva-Maria Damsgaard Nielsen, Hans-Christian Pedersen, Christian Krogh-Jensen

Publikováno v: Journal of biomolecular screening. 11(4)

The RAS-mitogen-activated protein kinase (MAPK) signaling pathway has a central role in regulating the proliferation and survival of both normal and tumor cells. This pathway has been 1 focus area for the development of anticancer drugs, resulting in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47fa1121ccaa13e89e2dc6708eaad465
https://pubmed.ncbi.nlm.nih.gov/16751337

Novel Small-Molecule AKT1 Inhibitors Discovered by Redistribution™-Based High- Throughput Screening

Autor: Betina Kerstin Lundholt, Viggo Linde, Morten Praestegaard, Morten Heide, Søren Jensby Nielsen, Steven Loechel, Ivan Mikkelsen

Publikováno v: ESACT Proceedings ISBN: 1402027915

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2870c4a20ab77f343a6b2235adf6d556
https://doi.org/10.1007/1-4020-3103-3_35

A simple technique for reducing edge effect in cell-based assays

Autor: Betina Kerstin, Lundholt, Kurt M, Scudder, Len, Pagliaro

Publikováno v: Journal of biomolecular screening. 8(5)

Several factors are known to increase the noise and variability of cell-based assays used for high-throughput screening. In particular, edge effects can result in an unacceptably high plate rejection rate in screening runs. In an effort to minimize t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::15ee4035e26185c412e4cd4ff1cca582
https://pubmed.ncbi.nlm.nih.gov/14567784