Mechanistic Studies of the Negative Epistatic Malaria-protective Interaction Between Sickle Cell Trait and α+thalassemia

Autor: J. Alexandra Rowe, Harold Ocholla, Bethsheba R. Siddondo, Thomas N. Williams, Metrine Tendwa, David J. P. Ferguson, Ashfaq Ghumra, Lucy B. Ochola, D. Herbert Opi, Harry Fanjo

Publikováno v: EBioMedicine
EBioMedicine, Vol 1, Iss 1, Pp 29-36 (2014)
Opi, D H, Ochola, L B, Tendwa, M, Siddondo, B R, Ocholla, H, Fanjo, H, Ghumra, A, Ferguson, D J P, Rowe, J A & Williams, T N 2014, ' Mechanistic studies of the negative epistatic malaria-protective interaction between sickle cell trait and α + thalassemia ', EBioMedicine, vol. 1, no. 1, pp. 29-36 . https://doi.org/10.1016/j.ebiom.2014.10.006

Background: Individually, the red blood cell (RBC) polymorphisms sickle cell trait (HbAS) and α+thalassemia protect against severe Plasmodium falciparum malaria. It has been shown through epidemiological studies that the co-inheritance of both condi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd5e37e96389d642f15218d6db0a73c
http://europepmc.org/articles/PMC4397954

Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome

Autor: Peter C. Bull, Britta C. Urban, Lucy B. Ochola, Johnstone Makale, Thomas N. Williams, Alister Craig, Bethsheba R. Siddondo, Eva N Kimani, Tadge Szestak, Harold Ocholla, Anne Liljander, Kevin Marsh, Siana Nkya

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e14741 (2011)
PLoS ONE

Our understanding of the basis of severe disease in malaria is incomplete. It is clear that pathology is in part related to the pro-inflammatory nature of the host response but a number of other factors are also thought to be involved, including the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc7dfea001edcdf132ea7d5f02c8ebd
http://europepmc.org/articles/PMC3048392?pdf=render

Mechanistic Studies of the Negative Epistatic Malaria-protective Interaction Between Sickle Cell Trait and α+thalassemia

Autor: D. Herbert Opi, Lucy B. Ochola, Metrine Tendwa, Bethsheba R. Siddondo, Harold Ocholla, Harry Fanjo, Ashfaq Ghumra, David J.P. Ferguson, J. Alexandra Rowe, Thomas N. Williams

Publikováno v: EBioMedicine, Vol 1, Iss 1, Pp 29-36 (2014)

Background: Individually, the red blood cell (RBC) polymorphisms sickle cell trait (HbAS) and α+thalassemia protect against severe Plasmodium falciparum malaria. It has been shown through epidemiological studies that the co-inheritance of both condi

Externí odkaz: https://doaj.org/article/b49fe2e2d808457da8390056ddfbc3f1