Výsledky vyhledávání - "Bethel, Stannard"

Protection against hypoxic–ischemic injury in transgenic mice overexpressing Kir6.2 channel pore in forebrain

Autor: Charles V. Mobbs, Yang Xue-jun, Teresa L. Wood, Bethel Stannard, Susan J. Vannucci, Catalina Hernández-Sánchez, Lisa B Willing, Derek LeRoith, Lisa Heron-Milhavet, Anne Virsolvy

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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9 páginas, 7 figuras, 2 tablas -- PAGS nros. 585-593
The role of the K-ATP channel pore-forming subunit Kir6.2 on protection from cerebral hypoxic–ischemic injury was assessed in transgenic mice overexpressing normal Kir6.2 or a dominant nega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a62be48c42bd25f96d3495841fdf5468
https://doi.org/10.1016/j.mcn.2003.10.012

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Peroxisome Proliferator–Activated Receptor-α Agonist Treatment in a Transgenic Model of Type 2 Diabetes Reverses the Lipotoxic State and Improves Glucose Homeostasis

Autor: Martin Haluzik, Daphne Yau, Marc L. Reitman, Bethel Stannard, Michael B. Wheeler, Homeostasis Kim, Shoshana Yakar, Lisa Heron-Milhavet, Jamie W. Joseph, Zeenat Asghar, Derek LeRoith, Ana M. Fernandez

Publikováno v: Scopus-Elsevier

Abnormalities in insulin action are the characteristics of type 2 diabetes. Dominant-negative muscle-specific IGF-I receptor (MKR) mice exhibit elevated lipid levels at an early age and eventually develop type 2 diabetes. To evaluate the role of elev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa204f6278792e326064702191fb5bd9
https://doi.org/10.2337/diabetes.52.7.1770

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Muscle-specific inactivation of the IGF-I receptor induces compensatory hyperplasia in skeletal muscle

Autor: Ana M. Fernández, Joëlle Dupont, Roger P. Farrar, Sukho Lee, Bethel Stannard, Derek Le Roith

Publikováno v: Journal of Clinical Investigation. 109:347-355

During the development of skeletal muscle, myoblasts withdraw from the cell cycle and differentiate into myotubes. The insulin-like growth factors IGF-I and IGF-II, through their cognate tyrosine kinase receptor (IGF-I receptor), are known to play a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2e4f6699cd0054965eda5575d3f549
https://doi.org/10.1172/jci0213503

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In vitroandin vivoresponses to short-term recombinant human insulin-like growth factor-1 (IGF-I) in a severely growth-retarded girl with ring chromosome 15 and deletion of a single allele for the type 1 IGF receptor gene

Autor: Romolo Sandrini, Saul Malozowski, Derek LeRoith, Luiz Alkimin de Lacerda, Bethel Stannard, Louis E. Underwood, Julienne A. R. Carvalho, Haim Werner, Margaret C. S. Boguszewski

Publikováno v: Clinical Endocrinology. 51:541-550

OBJECTIVES Patients with single allele defects in the gene encoding the type 1 IGF receptor have been reported to have growth failure, but fibroblasts from affected patients have not exhibited insensitivity to the effects of IGF-I in vitro. The in vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0555e07857029a1b939b2a16b7143a
https://doi.org/10.1046/j.1365-2265.1999.00799.x

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Normal growth and development in the absence of hepatic insulin-like growth factor I

Autor: Derek LeRoith, Domenici Accili, Andrew A. Butler, Brian C. Sauer, Jun L.I. Liu, Shoshana Yakar, Bethel Stannard

Publikováno v: Proceedings of the National Academy of Sciences. 96:7324-7329

The somatomedin hypothesis proposed that insulin-like growth factor I (IGF-I) was a hepatically derived circulating mediator of growth hormone and is a crucial factor for postnatal growth and development. To reassess this hypothesis, we have used the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac8ed46b94f3a290ea4bc7055ffa45e
https://doi.org/10.1073/pnas.96.13.7324

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Insulin-like Growth Factor-I Inhibits the Stress-activated Protein Kinase/c-Jun N-terminal Kinase

Autor: J. Silvio Gutkind, Yumiko Okubo, Vicky A. Blakesley, Bethel Stannard, Derek Le Roith

Publikováno v: Journal of Biological Chemistry. 273:25961-25966

The pathways involved in the cellular responses to the insulin-like growth factors (IGFs) are numerous and vary according to cell type. Following activation of the IGF-I receptor, the mitogen-activated protein kinase and phosphatidylinositide 3′-ki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e02950d5c5bc6045a2459c0b5d0654
https://doi.org/10.1074/jbc.273.40.25961

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Sphingosine 1-Phosphate Stimulates Tyrosine Phosphorylation of Crk

Autor: Vicky A. Blakesley, Sarah Spiegel, Sheela Rani, Derek LeRoith, Dana Beitner-Johnson, James R. Van Brocklyn, Zila Shen-Orr, Bethel Stannard

Publikováno v: Journal of Biological Chemistry. 272:16211-16215

The proto-oncogene molecule c-Crk plays a role in growth factor-induced activation of Ras. Sphingosine 1-phosphate (SPP), a metabolite of cellular sphingolipids, has previously been shown to play a role in growth factor receptor signaling (Olivera, A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466a6b10e94336eeccaf8fb7214ce55d
https://doi.org/10.1074/jbc.272.26.16211

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Role of the IGF-I receptor in mutagenesis and tumor promotion

Autor: Vicky A. Blakesley, Thea Kalebic, Derek LeRoith, Lee J. Helman, Bethel Stannard

Publikováno v: Journal of Endocrinology. 152:339-344

Introduction The insulin-like growth factor-I (IGF-I) receptor is a transmembrane protein tyrosine kinase which mediates the biological effects of IGF-I (LeRoith et al. 1995, Nissley & Lopaczynski 1991) and most of the actions of insulinlike growth f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf7bb3dd6c23d0c18cf988ccc33cb66
https://doi.org/10.1677/joe.0.1520339

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The Proto-oncogene Product c-Crk Associates with Insulin Receptor Substrate-1 and 4PS

Autor: Derek LeRoith, Ling-Mei Wang, Vicky A. Blakesley, Marce Jimenez, Dana Beitner-Johnson, Jacalyn H. Pierce, Zila Shen-Orr, Bethel Stannard

Publikováno v: Journal of Biological Chemistry. 271:9287-9290

The Crk proto-oncogene product is an SH2 and SH3 domain-containing adaptor protein which we have previously shown to become rapidly tyrosine phosphorylated in response to stimulation with insulin-like growth factor I (IGF-I) in NIH-3T3 cells. In orde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47f8d75c9a5600b807dce1d1e4a6c00a
https://doi.org/10.1074/jbc.271.16.9287

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