Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Bethany R. Baumgart"'
Autor:
Roderick T. Bunch, Terry R. Van Vleet, Thomas P. Sanderson, Bethany R. Baumgart, Jochen Woicke, Katherine L. Gray
Publikováno v:
Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants
Mitochondrial toxicity can be difficult to detect as most cells can tolerate reduced activity as long as minimal capacity for function is maintained. However, once minimal capacity is lost, apoptosis or necrosis occurs quickly. Identification of more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898a695f13c550ba5c4a5815706f16b1
https://doi.org/10.1016/j.taap.2015.10.007
https://doi.org/10.1016/j.taap.2015.10.007
Autor:
Marc H. Davies, Megan Fuller, Jamie J. Arnold, Craig E. Cameron, Terry Van Vleet, Michael J. Graziano, Thomas P. Sanderson, Damir Simic, Chris Storck, Catherine Euler, Oliver P. Flint, Bethany R. Baumgart, Suresh D. Sharma, Faye Wang, Roderick T. Bunch, Jae Kwagh
Publikováno v:
Toxicological Sciences
BMS-986094, the prodrug of a guanosine nucleotide analogue (2'-C-methylguanosine), was withdrawn from clinical trials due to serious safety issues. Nonclinical investigative studies were conducted as a follow up to evaluate the potential for BMS-9860
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f83bd630158a6ca1a75515f89888cc40
https://doi.org/10.1093/toxsci/kfw135
https://doi.org/10.1093/toxsci/kfw135
Autor:
Marc H. Davies, Roderick T. Bunch, Robert W. Lange, Bethany R. Baumgart, Michael Donegan, Damir Simic, Theodora W. Salcedo, Kimberley A. Lentz, Terry Van Vleet, Thomas P. Sanderson
Publikováno v:
Journal of Applied Toxicology. 35:791-798
The objective of this study was to evaluate potential protective effects of vehicles containing d-α-tocopheryl polyethylene glycol 1000 succinate (TPGS), which may impact nonclinical safety assessments of oxidative processes. This was achieved by ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::635f7d6cb8d0ab56a34aafd029e327fc
https://doi.org/10.1002/jat.3072
https://doi.org/10.1002/jat.3072
Autor:
Michael J. Graziano, Mausumee Guha, Julia Li, Nicola Wallis, Damir Simic, James Hennan, Bethany R. Baumgart, Jochen Woicke, Thomas P. Sanderson, Roderick T. Bunch
Publikováno v:
Cancer chemotherapy and pharmacology. 79(4)
Pulmonary arterial hypertension (PAH) results from occlusion or vasoconstriction of pulmonary vessels, leading to progressive right ventricular failure. Dasatinib, a BCR-ABL1 tyrosine kinase inhibitor (TKI) approved for the treatment of chronic myelo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c08283b00eb8606e79958f117abd3a
https://pubmed.ncbi.nlm.nih.gov/28283735
https://pubmed.ncbi.nlm.nih.gov/28283735
Autor:
Damir Simic, Roderick T. Bunch, Jochen Woiche, Michael J. Graziano, Mausumee Guha, Julia Li, Thomas P. Sanderson, Bethany R. Baumgart, James Hennan
Publikováno v:
Cancer Research. 73:2426-2426
Pulmonary arterial hypertension (PAH), defined by increase in mean pulmonary arterial pressure (PAP), results from occlusion or vasoconstriction of the pulmonary veins and can lead to progressive right ventricular failure. The tyrosine kinase inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be335139448c13dbd9f4d4f52063d99c
https://doi.org/10.1158/1538-7445.am2013-2426
https://doi.org/10.1158/1538-7445.am2013-2426