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Autor:
Bethany M. McElroy, Achim H. Krotz, Douglas L. Cole, Vasulinga T. Ravikumar, Anthony N. Scozzari
Publikováno v:
Organic Process Research & Development. 7:47-52
The last chemical step in standard oligonucleotide synthesis, the acid-catalyzed removal of 4,4‘-dimethoxytrityl (DMTr) protecting groups from the 5‘-terminus of oligonucleotides is accompanied by hydrolysis of purine nucleoside glycosidic linkag